Search results for "LSA"
showing 10 items of 832 documents
Simulación de estudios de bioequivalencia: Sensibilidad de los analitos en fármacos con farmacocinética similar al ácido acetilsalicílico y a la cafe…
2015
En los estudios de bioequivalencia se comparan las curvas de concentraciones plasmáticas-tiempo de un grupo de voluntarios a los que se les ha administrado el medicamento de referencia y el medicamento problema. Esa comparación se realiza evaluando la velocidad y magnitud de absorción del medicamento problema, con respecto al de referencia. Por ello, los parámetros analizados son el área bajo la curva (AUC, por sus siglas en inglés) y la concentración plasmática máxima (Cmax) (EMA, 2010). La EMA y la FDA (EMA, 2010; FDA, 2001, 2003) establecen que el intervalo de confianza del 90%, para la relación (test/referencia) de las medias geométricas poblacionales de los parámetros AUC y Cmax, debe …
Sinhrono un asinhrono rakstisko mijiedarbību vadīšana: mentoru un studentu saziņas analīze tālsadarbības projektā
2017
Attālinātu studentu grupu vadīšana ir viena no lielākajām grūtībām tālsadarbības projektos. Mentoru un studentu tieša kontakta trūkums ir būtisks ierobežojums, kas būtu jāņem vērā, jo dalībnieku saziņas dinamika ir būtisks faktors veiksmīgam tālsadarbības projektam. Pētījumā ir veikta kvalitatīva iegūtā korpusa pētīšana, iekļaujot datu ievākšanas, atlasīšanas, prezentēšanas un pārbaudes posmus. Pētījuma mērķis ir noteikt mentoru izvēlētās grupu vadīšanas stratēģijas visefektīvāko sinhrono un asinhrono rakstisko mijiedarbību laikā, saistībā ar studentu izaugsmi tālsadarbības projektā. Šajā pētījumā tiek uzdoti divi galvenie jautājumi: 1.Kādas ir tiešsaistes pedagoģisko mijiedarbību metodes? …
Valpromide is a poor inhibitor of the cytosolic epoxide hydrolase
1989
The effect of the antiepileptics valpromide and sodium valproate on the cytosolic epoxide hydrolase was studied in human fetal liver, kidneys and adrenals and from human adult liver and kidneys. Trans-stilbene oxide was used as substrate. Valpromide (10 mM) lowered the activity of the epoxide hydrolase to one half of the control in all organs studied. Sodium valproate (10 mM) was less powerful as an inhibitor than valpromide; however, it exerted a significant inhibition in all tissues studied.
Agent-based modelling of values: the case of value sensitive design for refugee logistics
2020
We have used value sensitive design as a method to develop an agent-based model of values in humanitarian logistics for refugees. Schwartz's theory of universal values is implemented in the model in such a way that agents can make value trade-offs, which are operationalized into a measure of refugee wellbeing and a measure of public opinion about how the refugee logistics is being handled. By trying out different ‘value-scenarios’, stakeholders who are responsible for, or involved in refugee logistics can have insights into the effects of various value choices. The model is visualized and made usable as a platform (interactive website) for decision-makers to understand the trade-offs in pol…
Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis
2010
A genetic basis of hepatocellular carcinoma (HCC) has been well-established and major signaling pathways, such as p53, Wnt-signaling, transforming growth factor-β (TGF-β) and Ras pathways, have been identified to be essential to HCC development. Lately, the family of platelet-derived growth factors (PDGFs) has shifted to the center of interest. We have reported on spontaneously developing liver fibrosis in PDGF-B transgenic mice. Since HCC rarely occurs in healthy liver, but dramatically increases at the cirrhosis stage of which liver fibrosis is a preliminary stage, we investigated liver cancer development in chemically induced liver carcinogenesis in these mice. HCC induction was performe…
Retrieval of vegetation height in rice fields using polarimetric SAR interferometry with TanDEM-X data
2017
This work presents for the first time a demonstration with satellite data of polarimetric SAR interferometry (PolInSAR) applied to the retrieval of vegetation height in rice fields. Three series of dual-pol interferometric SAR data acquired with large baselines (2–3 km) by the TanDEM-X system during its science phase (April–September 2015) are exploited. A novel inversion algorithm especially suited for rice fields cultivated in flooded soil is proposed and evaluated. The validation is carried out over three test sites located in geographically different areas: Sevilla (SW Spain), Valencia (E Spain), and Ipsala (W Turkey), in which different rice types are present. Results are obtained duri…
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
2003
A topological virtual screening (tvs) test is presented, which is capable of identifying new drug leaders with anticonvulsant activity. Molecular structures of both anticonvulsant-active and non active compounds, extracted from the Merck Index database, were represented using topological indexes. By means of the application of a linear discriminant analysis to both sets of structures, a topological anticonvulsant model (tam) was obtained, which defines a connectivity function. On the basis of this model, 41 new structures with anticonvulsant activity have been identified by a topological virtual screening.
Retention–property relationships of anticonvulsant drugs by biopartitioning micellar chromatography
2001
Epilepsy may be considered as a group of disorders with only one thing in common: the fact that recurrent anomalous electrochemical phenomena appear in the central nervous system. Different classes of drugs are included under the generic term of anticonvulsant drugs. All of them work by decreasing discharge propagation in different ways. Biopartitioning micellar chromatography (BMC) is a mode of reversed-phase liquid chromatography, which can be used as an in vitro system to model the biopartitioning process of drugs when there are no active processes. In this paper, relationships between the BMC retention data of anticonvulsant drugs, their pharmacokinetics (oral absorption, protein bindin…
La cultura ci salverà? Processi di touristification a base culturale nel centro storico di Palermo
2023
Negli ultimi tre decenni la cultura ha avuto un ruolo chiave nella costruzione delle politiche urbane, divenendo uno strumento decisivo nella definizione delle strategie di sviluppo economico e nell’accesso alla competizione globale che caratterizzano l’attuale regime di neoliberismo urbano (Miles e Paddison 2005). Anche nel sud Europa la cosiddetta rigenerazione a base culturale ha rappresentato e continua ancora oggi a rappresentare una vera e propria ortodossia urbana, che trova nel turismo tanto una ragione di esistenza quanto un campo di attuazione. In particolare, negli ultimi anni i centri storici di molte città sudeuropee sono stati oggetto di trasformazioni profonde in cui pratiche…
Prosjektarbeid i barnehagen – mellom bekvemmelighet og medvirkning
2021
I denne artikkelen analyseres samtaler fra personalmøter i to barnehager som arbeider prosjektbasert inspirert av Reggio Emilia-pedagogikk. Observasjoner av møter er supplert med intervju med de pedagogiske lederne. Målet med undersøkelsen har vært å studere hvordan personalet snakker sammen om arbeid med prosjekt i møtene og hvordan dette kan ha betydning for barns mulighet for medvirkning. Vi viser hvordan samtalene arter seg gjennom et prosjektforløp. Underveis i denne prosessen identifiserte vi fire ulike diskurser som på ulike måter legger føringer for barnas medvirkning i arbeidet med prosjektene. Vi har kalt disse for henholdsvis en medvirkningsdiskurs, en undringsdiskurs, en bekvemm…