Search results for "LUDI"
showing 10 items of 753 documents
Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A
2012
Abstract Background Malignant diseases are responsible of approximately 13% of all deaths each year in the world. Natural products represent a valuable source for the development of novel anticancer drugs. The present study was aimed at evaluating the cytotoxicity of a naphtyl butanone isolated from the leaves of Guiera senegalensis, guieranone A (GA). Results The results indicated that GA was active on 91.67% of the 12 tested cancer cell lines, the IC50 values below 4 μg/ml being recorded on 83.33% of them. In addition, the IC50 values obtained on human lymphoblastic leukemia CCRF-CEM (0.73 μg/ml) and its resistant subline CEM/ADR5000 (1.01 μg/ml) and on lung adenocarcinoma A549 (0.72 μg/m…
Exosomal Heat Shock Proteins as New Players in Tumour Cell-to-cell Communication
2014
Exosomes have recently been proposed as novel elements in the study of intercellular communication in normal and pathological conditions. The biomolecular composition of exosomes reflects the specialized functions of the original cells. Heat shock proteins (Hsps) are a group of chaperone proteins with diverse biological roles. In recent years, many studies have focused on the extracellular roles played by Hsps that appear to be involved in cancer development and immune system stimulation. Hsps localized on the surface of exosomes, secreted by normal and tumour cells, could be key players in intercellular cross-talk, particularly during the course of different diseases, such as cancer. Exoso…
Biodistribution, Uptake and Effects Caused by Cancer-derived Extracellular Vesicles
2015
Extracellular vesicles (EVs) have recently emerged as important mediators of intercellular communication. They are released in the extracellular space by a variety of normal and cancerous cell types and have been found in all human body fluids. Cancer-derived EVs have been shown to carry lipids, proteins, mRNAs, non-coding and structural RNAs and even extra-chromosomal DNA, which can be taken up by recipient cells and trigger diverse physiological and pathological responses. An increasing body of evidence suggests that cancer-derived EVs mediate paracrine signalling between cancer cells. This leads to the increased invasiveness, proliferation rate and chemoresistance, as well as the acquisi…
WASTE DUMPS IN LATVIA: FORMER LANDFILLING, CONSEQUENCES AND POSSIBLE RECULTIVATION
2012
Particular attention in this article is paid to the research of two waste dumps in the capital city of Latvia – Riga, which are planned to be re-cultivated in the nearest future and one site, which is former toxic hazardous soil dump site, where the remediation of site is of priority need. The present study is giving a general overview of contamination level in two waste dumps in Riga, which were made in the period from 50-ties to 70-ties of the 20th century, also the case of hazardous soil dump site formed in a period of more than 100 years is described. Planned actions as well as direct remediational technologies to reduce the poisonous impact to the urban environment and the role of re-c…
Gliadin, zonulin and gut permeabilità: effects on celiac and non-celiac intestinal mucosa and intestinal cell lines.
2006
Objective. Little is known about the interaction of gliadin with intestinal epithelial cells and the mechanism(s) through which gliadin crosses the intestinal epithelial barrier. We investigated whether gliadin has any immediate effect on zonulin release and signaling. Material and methods. Both ex vivo human small intestines and intestinal cell monolayers were exposed to gliadin, and zonulin release and changes in paracellular permeability were monitored in the presence and absence of zonulin antagonism. Zonulin binding, cytoskeletal rearrangement, and zonula occludens-1 (ZO-1) redistribution were evaluated by immunofluorescence microscopy. Tight junction occludin and ZO-1 gene expression …
Distrés emocional y problemas asociados en población oncológica adulta
2017
Objetivo: en este estudio se estima la prevalencia de distrés, se identifican los problemas asociados y se analiza el conocimiento y uso que hacen los pacientes sobre los recursos psicosociales disponibles en el centro hospitalario. Método: se lleva a cabo un estudio transversal en el que participan 203 pacientes oncológicos que están recibiendo tratamiento quimioterápico. En la evaluación se emplean el Inventario de Síntomas Breve-18 (BSI-18), el Listado de Problemas de NCCN y una encuesta sobre el conocimiento y uso de los recursos asistenciales del centro hospitalario. Resultados: la prevalencia de distrés en la muestra total es del 26%. Los problemas físicos son la principal fuente de d…
Evaluación de las alteraciones psicológicas y de la calidad de vida en pacientes con cáncer colorrectal localizado
2016
En los paises desarrollados y en la mayoria del mundo industrializado, el cancer constituye uno de los mayores problemas de salud siendo una de las enfermedades mas prevalentes. En la actualidad, la estimacion en Espana sobre incidencia resalta que el cancer mas frecuente teniendo en cuenta ambos sexos, con una prevision a 5 anos, es el cancer colorrectal. El principal factor pronostico es el estadio clinico en el momento de la cirugia, pero en los ultimos anos se han desarrollado diversos programas de tratamiento adyuvante con quimioterapia y radioterapia para el cancer colorrectal. Un 70% de estos tumores son de localizacion proximal (colon), mientras que el resto son distales (recto). Es…
Cribado de distrés emocional en población oncológica adulta: validación de instrumentos
2017
La investigacion ha demostrado la presencia de niveles de distres (o malestar emocional) clinicamente significativos en aproximadamente tres de cada diez pacientes oncologicos (Mitchell et al., 2011). Sin embargo, en la actualidad, menos de la mitad de estos pacientes son identificados y derivados a los servicios de asistencia psicosocial (NCCN, 2015). El fracaso a la hora de detectar y tratar adecuadamente sus necesidades emocionales conlleva una serie de importantes consecuencias negativas que repercuten no solo en la calidad de vida de los pacientes (Shim et al., 2006) y en su nivel de satisfaccion con la atencion medica recibida (Von Essen, Larsson, Oberg y Sjoden, 2002), sino tambien e…
A Nomogram-Based Prognostic Model for Advanced Hepatocellular Carcinoma Patients Treated with Sorafenib: A Multicenter Study
2021
Simple Summary Accurate prognostic systems capable of predicting the survival of patients with advanced hepatocellular carcinoma undergoing Sorafenib therapy are still lacking. The search for the ideal predictive tool for survival and drug response is justified by the recent availability of several other drugs effective for these patients, licensed as first- and second-line treatment, other than reducing adverse events and costs. In this study, we aimed to identify simple demographic and clinical parameters able to predict survival and Sorafenib response in a large multicenter cohort. In this study, we showed that patient’s general status, liver function and damage laboratory parameters and…