Search results for "Lability"
showing 10 items of 802 documents
Milk versus caseinophosphopeptides added to fruit beverage: Resistance and release from simulated gastrointestinal digestion
2010
The influence of simulated gastrointestinal digestion on caseinophosphopeptides (CPPs) formation in milk-based fruit beverage was evaluated, together with resistance of a pool of CPPs added to fruit beverage. In milk-based fruit beverage, four CPPs were identified that can be justified by their presence in raw milk or due to processing. When it was subjected to simulated gastrointestinal digestion, 10 CPPs were identified, and only 1 presented the cluster (SpSpSpEE) (3 phosphoseryl group followed by 2 glutamic acid residues), which corresponded to αs2-CN(1-19)4P. CPPs added to fruit beverage are resistant to simulated gastrointestinal digestion, and 16 CPPs were identified originating from …
Effects of different infant formula components on calcium dialysability
1999
The in vitro methods proposed for estimating calcium bioavailability can be useful in studying the effect of dietetic factors. The aim of our work was to study the possible influence of different infant formula components – calcium, phosphorus, lactose, citric acid, ascorbic acid and proteins – on calcium bioavailability, considering dialysability to be an estimate of bioavailability. The 1981 method of Miller et al. with slight modifications (concerted action no 10 – FLAIR project) was applied to 18 commercial infant formulas of six different types: adapted, follow-up, preterm, hydrolysates, lactose-free and soy-based. Significant positive linear correlations between the amount of calcium …
Benchmark coupled-cluster g-tensor calculations with full inclusion of the two-particle spin-orbit contributions.
2017
We present a parallel implementation to compute electron spin resonance g-tensors at the coupled-cluster singles and doubles (CCSD) level which employs the ACES III domain-specific software tools for scalable parallel programming, i.e., the super instruction architecture language and processor (SIAL and SIP), respectively. A unique feature of the present implementation is the exact (not approximated) inclusion of the five one- and two-particle contributions to the g-tensor [i.e., the mass correction, one- and two-particle paramagnetic spin-orbit, and one- and two-particle diamagnetic spin-orbit terms]. Like in a previous implementation with effective one-electron operators [J. Gauss et al.,…
Teleportation-assisted optical controlled-sign gates
2019
Reliable entangling gates for qubits encoded in single-photon states represent a major challenge on the road to scalable quantum computing architectures based on linear optics. In this work, we present two approaches to develop high-fidelity, near-deterministic controlled-sign-shift gates based on the techniques of quantum gate teleportation. On the one hand, teleportation in a discrete-variable setting, i.e., for qubits, offers unit-fidelity operations but suffers from low success probabilities. Here, we apply recent results on advanced linear optical Bell measurements to reach a near-deterministic regime. On the other hand, in the setting of continuous variables, associated with coherent …
Search for excited leptons in Z0 decay
1990
Due to the severity of system-wide power outages, though their probability of occurrence is slight, regulatory authorities require that a system restoration plan be drawn up and kept up to date at all times. The power outage that affected northeastern North America in 2003 proved the need for such a requirement. The particular structure of Hydro-Quebec's power system requires the use of a highly specific system restoration procedure. The daily preparation of the system restoration plan is based on a strategy whose application requires that a restoration sequence be drawn up that uses available equipment, the electrical behavior of which has been validated using appropriate studies. Over the…
Robust single-parameter quantized charge pumping
2008
This paper investigates a scheme for quantized charge pumping based on single-parameter modulation. The device was realized in an AlGaAs-GaAs gated nanowire. We find a remarkable robustness of the quantized regime against variations in the driving signal, which increases with applied rf power. This feature together with its simple configuration makes this device a potential module for a scalable source of quantized current.
Strong quantum scarring by local impurities
2016
We discover and characterize strong quantum scars, or eigenstates resembling classical periodic orbits, in two-dimensional quantum wells perturbed by local impurities. These scars are not explained by ordinary scar theory, which would require the existence of short, moderately unstable periodic orbits in the perturbed system. Instead, they are supported by classical resonances in the unperturbed system and the resulting quantum near-degeneracy. Even in the case of a large number of randomly scattered impurities, the scars prefer distinct orientations that extremize the overlap with the impurities. We demonstrate that these preferred orientations can be used for highly efficient transport of…
Formulation predictive dissolution (fPD) testing to advance oral drug product development: an introduction to the US FDA funded ‘21st Century BA/BE’ …
2018
Over the past decade, formulation predictive dissolution (fPD) testing has gained increasing attention. Another mindset is pushed forward where scientists in our field are more confident to explore the in vivo behavior of an oral drug product by performing predictive in vitro dissolution studies. Similarly, there is an increasing interest in the application of modern computational fluid dynamics (CFD) frameworks and high-performance computing platforms to study the local processes underlying absorption within the gastrointestinal (GI) tract. In that way, CFD and computing platforms both can inform future PBPK-based in silico frameworks and determine the GI-motility-driven hydrodynamic impac…
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and ov…
2016
Orally administered drugs are subject to a number of barriers impacting bioavailability (Foral), causing challenges during drug and formulation development. Physiologically-based pharmacokinetic (PBPK) modelling can help during drug and formulation development by providing quantitative predictions through a systems approach. The performance of three available PBPK software packages (GI-Sim, Simcyp®, and GastroPlus™) were evaluated by comparing simulated and observed pharmacokinetic (PK) parameters.Since the availability of input parameters was heterogeneous and highly variable, caution is required when interpreting the results of this exercise. Additionally, this prospective simulation exer…
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysin…
2016
Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp® Simulator, and GastroPlus™) were evaluated as part of the Innovative Medicine Initiative Oral Biopharmaceutics Tools project (OrBiTo) during a blinded “bottom-up” anticipation of human pharmacokinetics. After data analysis of the predicted vs. measured pharmacokinetics parameters, it was found that oral bioavailability (Foral) was underpredicted for compounds with low permeability, suggesting improper estimates of intestinal surface area, colonic absorption and/or lack of intestinal transporter information. Foral was also underpredicted for acidic compounds, suggesting overestimation of impact of ionisation on pe…