Search results for "Lag"
showing 10 items of 3124 documents
Enzymatic alteration of C1q, the collagen-like subcomponent of the first component of complement, leads to cross-reactivity with type II collagen
1988
AbstractNative serum C1q, the collagenous-like subcomponent of the first component of complement, is not recognized by polyclonal anti-collagen type II antibodies. However, when purified C1q was subjected to limited proteolysis by collagenase it showed antigenic cross-reactivity with collagen type II. The same cross-reactivity was observed with hemolytically active C1q in synovial fluids of patients with rheumatoid arthritis (RA), whereas C1q from synovial fluids of patients with osteoarthritis (OA), villo-nodular synovitis and ankylosing spondylitis was not recognized by this antibody. However, incubation of synovial fluid C1q of OA patients with synovial fluid leucocytes from RA patients …
Evidence for the presence of autoantibodies to the collagen-like portion of C1q in systemic lupus erythematosus.
1988
We investigated the connection between the C1q solid-phase binding assay (C1q SPBA) and double-stranded DNA antibodies, and analyzed the immune complex material in systemic lupus erythematosus (SLE) sera. Comparison with a new monoclonal assay for C1q-bearing immune complexes (the 242G3 assay) revealed that the immune complexes in SLE bind specifically to solid-phase C1q, and not to fluid-phase C1q. The C1q solid-phase binding activity sedimented as 7S IgG, was insensitive to DNase treatment, and could be selectively absorbed by C1q-coupled beads and by bovine serum albumin-anti-bovine serum albumin C1q beads, but not by DNA. Thus, antibodies to double-stranded DNA do not interfere in the C…
Alternative and complementary therapies in osteoarthritis and cartilage repair
2020
Osteoarthritis (OA) is the most common joint condition and, with a burgeoning ageing population, is due to increase in prevalence. Beyond conventional medical and surgical interventions, there are an increasing number of ‘alternative’ therapies. These alternative therapies may have a limited evidence base and, for this reason, are often only afforded brief reference (or completely excluded) from current OA guidelines. Thus, the aim of this review was to synthesize the current evidence regarding autologous chondrocyte implantation (ACI), mesenchymal stem cell (MSC) therapy, platelet-rich plasma (PRP), vitamin D and other alternative therapies. The majority of studies were in knee OA or chond…
Residuenabschätzung für Polynom-Nullstellen mittels Lagrange-Interpolation
1970
If, for each zero of a polynomial, an approximation is known, estimates for the errors of these approximations are given, based on the evaluation of the polynomial at these points. The procedure can be carried over to the case of multiple roots and root clusters using derivatives up to the orderk - 1, wherek is the multiplicity of the cluster.
A Computational Technique for Solving Singularly Perturbed Delay Partial Differential Equations
2021
Abstract In this work, a matrix method based on Laguerre series to solve singularly perturbed second order delay parabolic convection-diffusion and reaction-diffusion type problems involving boundary and initial conditions is introduced. The approximate solution of the problem is obtained by truncated Laguerre series. Moreover convergence analysis is introduced and stability is explained. Besides, a test case is given and the error analysis is considered by the different norms in order to show the applicability of the method.
An abstract inf-sup problem inspired by limit analysis in perfect plasticity and related applications
2021
This paper is concerned with an abstract inf-sup problem generated by a bilinear Lagrangian and convex constraints. We study the conditions that guarantee no gap between the inf-sup and related sup-inf problems. The key assumption introduced in the paper generalizes the well-known Babuška–Brezzi condition. It is based on an inf-sup condition defined for convex cones in function spaces. We also apply a regularization method convenient for solving the inf-sup problem and derive a computable majorant of the critical (inf-sup) value, which can be used in a posteriori error analysis of numerical results. Results obtained for the abstract problem are applied to continuum mechanics. In particular…
The ten grand challenges of synthetic life
2011
The construction of artificial life is one of the main scientific challenges of the Synthetic Biology era. Advances in DNA synthesis and a better understanding of regulatory processes make the goal of constructing the first artificial cell a realistic possibility. This would be both a fundamental scientific milestone and a starting point of a vast range of applications, from biofuel production to drug design. However, several major issues might hamper the objective of achieving an artificial cell. From the bottom-up to the selection-based strategies, this work encompasses the ten grand challenges synthetic biologists will have to be aware of in order to cope with the task of creating life i…
Cooperative compressive power spectrum estimation in wireless fading channels
2017
This paper considers multiple wireless sensors that cooperatively estimate the power spectrum of the signals received from several sources. We extend our previous work on cooperative compressive power spectrum estimation to accommodate the scenario where the statistics of the fading channels experienced by different sensors are different. The signals received from the sources are assumed to be time-domain wide-sense stationary processes. Multiple sensors are organized into several groups, where each group estimates a different subset of lags of the temporal correlation. A fusion centre (FC) combines these estimates to obtain the power spectrum. As each sensor group computes correlation esti…
Performing transnational family with the affordances of mobile apps : a case study of Polish mothers living in Finland
2020
Affordances provided by digital technologies and mobile apps (WhatsApp, Skype, Messenger) help in maintaining familyhood. These mobile apps enable the creation of in-app family groups. They also afford image sharing, which is used for phatic purposes. Digital connectivity provides the illusions of togetherness and belonging, and allows for performing family in a transnational context (emotional transnationalism). However, it also generates the feelings of guilt through infrequent communication. In the auto-driven visual elicitation interviews, the study looks at family constellations and technologically mediated communication from the perspective of five Polish mothers living in Finland. Ap…
“The Same Staff Can Be Enough”. Employers’ Resilience Strategies in Recruitment Decisions
2018
Studies on resilience have sprung from a need to understand the survival strategies of organizations when faced with the emergence of unexpected, potentially destructive and negative events in the lives of the organizations. This article, on the other hand, intends to highlight organizational resilience when confronted with unexpected positive events, seldom considered by such studies. This is the well-known macroeconomic phenomenon of the time lag between economic growth and labor demand at the moment that a regressive economic cycle is reversed. With which strategies do companies, in the face of such an event, transform a resilient attitude into real resilient behavior? Five strategies of…