Search results for "Lambda"
showing 10 items of 632 documents
SeroGRID: an improved method for the rapid selection of antigens with disease related immunogenicity
2003
Screening of cDNA expression libraries derived from human tumors with autologous sera (SEREX) permits the definition of immunogenic antigens in individual cancer patients. However, only a minority of SEREX-derived cDNA clones show a clear cancer-relatedness in the sense that circulating autoantibodies to them occur exclusively in the sera of tumor patients but not in healthy individuals. Evaluation of multiple SEREX-defined clones in serological assays using panels of allogeneic sera from cancer patients as well as appropriate control groups is an important step towards focussing on the relevant antigens. This in turn is the basis for defining disease parameters of diagnostic and prognostic…
Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells.
1999
Abstract Circulating plasma cells in 10 cases of reactive plasmacytosis had a shared phenotype with early plasma cell (CD19+CD38+ CD138+ CD40+CD45+ CD11a+ CD49e−CD56−). In most cases, a minor subpopulation of CD28+ plasma cells was also detected. Reactive plasma cells were highly proliferative, suggesting the presence of circulating progenitors (plasmablasts). After CD138+ plasma cell removal, highly proliferative CD138− plasmablasts differentiated into CD138+ plasma cells within a few days. This differentiation, which was associated with increased CD38 and decreased HLA-DR expression, was further confirmed by a large increase in intracellular Ig content (associated with Ig secretion) and w…
The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia.
2011
AbstractIdentification of patients at risk of early disease progression is the mainstay of tailored management in chronic lymphocytic leukemia (CLL). Although application of established biomarkers is limited by intrinsic detection/readout complexities, abnormality of κ and λ serum-free light chain ratio [sFLC (κ/λ)] was proposed as a straightforward prognosticator in CLL. By analyzing 449 therapy-naive patients, we show that an abnormal sFLC(κ/λ), along with CD38, ZAP-70, IGHV mutations, cytogenetics and stage, independently predicts treatment-free survival (TFS) but becomes prognostically irrelevant if the cumulative amount of clonal and nonclonal FLCs [sFLC(κ + λ)], a variable associated …
Variation in genes encoding for interferon λ-3 and λ-4 in the prediction of HCV-1 treatment-induced viral clearance
2013
Background & Aims In patients with chronic HCV-1 infection, recent evidences indicate that determination of a dinucleotide polymorphism (ss469415590, ΔG/TT) of a new gene, designated IFN λ-4, might be more accurate than the 12979860CC type of the IL28B locus in predicting sustained virological response (SVR) following peg-interferon and ribavirin. In addition, combined genotyping of different SNPs of the IL28B locus was shown to help dissect patients most prone to SVR among those with rs12979860CT. We examined whether single or combined genotyping of two IL28B SNPs, rs12979860 and rs8099917, and ss469415590 variation might improve the prediction of SVR. Results In the study cohort of 539 pa…
Pathogenesis of Paraneoplastic Follicular Hyperkeratotic Spicules in Multiple Myeloma
1990
• We describe a 62-year-old man with multiple myeloma who developed horny spicules on his face, particularly on his nose. IgG-λ monoclonal gammopathy was detected, and the serum dysprotein was shown to be a cryoglobulin, which forms a cryogel at low temperatures. Light and electron microscopic and immunohistochemical examinations showed an intercellular precipitation and massive accumulation of the IgG dysprotein and cryoglobulin between the keratinocytes of the upper epidermis and the infundibular epithelium. The follicles were dilated and filled with parakeratotic cells, the protein deposits between them and a rudimentary hair thus resulting in the clinically visible symptoms of horny spi…
Klasiskas un robustas MANOVA analīzes metodes
2019
Daudzdimensiju dispersiju analīze (MANOVA) tiek pielietota situācijās, kad tiek mērīti vairāki mainīgie katrai eksperimentālai vienībai. Darbā aplūkota teorija par klasisko MANOVA metodi un robusto MANOVA metodi, to pieņēmumiem un pielietojumiem. Bieži datos tiek novēroti izlēcēji, kuri atšķiras no pārējiem datiem. Analizējot datus, šie izlēcēji var būtiski ietekmēt parametru novērtējumus, šādās situācijās ieteicams izmantot robustas statistikas metodes. Tika secināts, ka robustā MANOVA metode ne vienmēr dod precīzākus rezultātus par klasisko MANOVA metodi. Atslēgas vārdi: Daudzdimensiju analīze, MANOVA, robusta MANOVA, Vilksa Lambda statistika
TeO2 liquid phase: Viscosity measurements and evaluation of the thermal conductivity from crystal growth experiments
2008
Current applications of paratellurite TeO{sub 2} in optics and nuclear physics require improving the yield and optical quality of synthesized single crystals. Modelling of the growth process is a useful tool for such purpose, however, involving the knowledge of several thermodynamic parameters of both solid and liquid phase of the compound. This work describes the determination of two main unknown ones, namely dynamic viscosity {eta} and thermal conductivity {lambda}{sub l} of the liquid phase. Measurements of {eta} are performed by means of a specifically designed apparatus; over a 40 K temperature interval above the melting point we find a mean value of 0.028 Pa.s. This data is used in co…
Lattice-Matched GaN–InAlN Waveguides at $\lambda=1.55\ \mu$m Grown by Metal–Organic Vapor Phase Epitaxy
2008
We report on the demonstration of low-loss, single-mode GaN-InAlN ridge waveguides (WGs) at fiber-optics telecommunication wavelengths. The structure grown by metal-organic vapor phase epitaxy contains AlInN cladding layers lattice-matched to GaN. For slab-like WGs propagation losses are below 3 dB/mm and independent of light polarization. For 2.6-mum-wide WGs the propagation losses in the 1.5- to 1.58-mum spectral region are as low as 1.8 and 4.9 dB/mm for transverse-electric- and transverse-magnetic-polarization, respectively. The losses are attributed to the sidewall roughness and can be further reduced by the optimization of the etching process.
SMAA-TRI
2007
ELECTRE TRI is a multiple criteria decision aiding sorting method with a history of successful real-life applications. In ELECTRE TRI, values for certain parameters, such as criteria weights, thresholds, category profiles, and lambda cutting level, have to be provided. We propose a new method, SMAA-TRI, that is based on Stochastic Multicriteria Acceptability Analysis (SMAA), for analyzing the stability of such parameters. The stability analysis can be used for deriving robust conclusions. SMAATRI allows ELECTRE TRI to be used with imprecise, arbitrarily distributed values for weights and the lambda cutting level. The method consists of analyzing through Monte Carlo simulation finite spaces …
Evaluation of T7 and lambda phage display systems for survey of autoantibody profiles in cancer patients.
2008
In the current study we attempted to evaluate the suitability of T7 Select 10-3b and lambdaKM8 phage display systems for the identification of antigens eliciting B cell responses in cancer patients and the production of phage-displayed antigen microarrays that could be exploited for the monitoring of autoantibody profiles. Members of 15 tumour-associated antigen (TAA) families were cloned into both phage display vectors and the TAA mini-libraries were immunoscreened with 22 melanoma patients' sera resulting in the detection of reactivity against members of 5 antigen families in both systems, yet with variable sensitivity. T7 phage display system showed greater sensitivity for the detection …