Search results for "Layers"
showing 10 items of 335 documents
N- and O-methylation of sphingomyelin markedly affects its membrane properties and interactions with cholesterol
2011
We have prepared palmitoyl sphingomyelin (PSM) analogs in which either the 2-NH was methylated to NMe, the 3-OH was methylated to OMe, or both were methylated simultaneously. The aim of the study was to determine how such modifications in the membrane interfacial region of the molecules affected interlipid interactions in bilayer membranes. Measuring DPH anisotropy in vesicle membranes prepared from the SM analogs, we observed that methylation decreased gel-phase stability and increased fluid phase disorder, when compared to PSM. Methylation of the 2-NH had the largest effect on gel-phase instability (T(m), was lowered by similar to 7 degrees C). Atomistic molecular dynamics simulations sho…
Optical Gating of Photosensitive Synthetic Ion Channels
2011
4-oxo-4-(pyren-4-ylmethoxy) butanoic acid is used as a photolabile protecting group to show the optical gating of nanofluidic devices based on synthetic ion channels. The inner surface of the channels is decorated with monolayers of photolabile hydrophobic molecules that can be removed by irradiation, which leads to the generation of hydrophilic groups. This process can be exploited in the UV-light-triggered permselective transport of ionic species in aqueous solution through the channels. The optical gating of a single conical nanochannel and multichannel polymeric membranes is characterised experimentally and theoretically by means of current-voltage and selective permeation measurements,…
INJURY PREVENTION IN YOUNG SOCCER PLAYERS: RESULTS OF A PILOT STUDY
2012
Risk factors for soccer injuries and prevention have been discussed by several authors, but only few have investigated the effectiveness of preventive interventions, in particular in the last few years. The aim of the present study was to evaluate the effects of a prevention program on the incidence of soccer-related injuries in three different categories of younger players (Allievi, Giovanissimi e Primavera). The soccer teams took part in a prevention program to decrease injury risk, for two agonistic seasons (2005-06, 2006-07). Before identifying training programs, we valued the younger fitness status: each youth soccer players (aged 13 to 19) performed exercise tests of functional capaci…
Kinetics of the lipoperoxyl radical-scavenging activity of indicaxanthin in solution and unilamellar liposomes
2007
Abstract The reaction of the phytochemical indicaxanthin with lipoperoxyl radicals generated in methyl linoleate methanol solution by 2,20-azobis(2,4-dimethylvaleronitrile), and in aqueous soybean phosphatidylcholine unilamellar liposomes by 2,20-azobis(2- amidinopropane)hydrochloride, was studied. The molecule acts as a chain-terminating lipoperoxyl radical scavenger in solution, with a calculated inhibition constant of 3.63 £ 105M21 s21, and a stoichiometric factor approaching 2. Indicaxanthin incorporated in liposomes prevented lipid oxidation, inducing clear-cut lag periods and decrease of the propagation rate. Both effects were concentration-dependent, but not linearly related to the p…
Vibrational Sum Frequency Generation Spectroscopy of the Water Liquid–Vapor Interface from Density Functional Theory-Based Molecular Dynamics Simulat…
2013
International audience; The vibrational sum frequency generation (VSFG) spectrum of the water liquid-vapor (LV) interface is calculated using density functional theory-based molecular dynamics simulations. The real and imaginary parts of the spectrum are in good agreement with the experimental data, and we provide an assignment of the SFG bands according to the dipole orientation of the interfacial water molecules. We use an instantaneous definition of the surface, which is more adapted to the study of interfacial phenomena than the Gibbs dividing surface. By calculating the vibrational (infrared, Raman) properties for interfaces of varying thickness, we show that the bulk spectra signature…
Characterization of impervious layers using scale models and an inverse method
2009
We describe a novel procedure that uses an inverse method to determine unknown parameters for impervious layers used in multilayer structures. The proposed model of the multilayer structure is limited to an ideal double plate separated by an unbonded, fibrous, sound-absorbing material. Experimental data were obtained by nearfield acoustic holography for the calculation of the transmission loss of various multilayer structures mounted in a window in a wooden box designed specifically for this purpose. We used the Trochidis and Kalaroutis forecast model of acoustic insulation for multilayer structures, which is based on a spatial Fourier transform. The experimental pressure and velocity data …
OpenLayers izmantošana Android ĢIS lietotnē
2015
“OpenLayers izmantošana Android ĢIS lietotnē” ir kvalifikācijas darbs, kurā tika izstrādāta hibrīd Android lietotne. Lietotne domāta cilvēkiem, kas vēlas iemūžināt bildes un vēlāk tās apskatīt kartē, lai redzētu kurā vietā bildes tika uzņemtas, kā arī redzēt pārējās bildes, kas tika uzņemtas šajā vietā vai tās tuvumā. Papildus tam, lietotni var izmantot, lai orientētos apkārtnē un, lai apskatītu savu veikto ceļu. Projekts realizēts pēc spējās izstrādes metodoloģijas. Izstrādes procesā tika izmantota OpenLayers JavaScript bibliotēka, AngularJS ietvars, MySQL datubāze un programmēšanas valodas Java, PHP un JavaScript.
Unsaturated Fatty Acids Drive Disintegrin and Metalloproteinase (ADAM)-dependent Cell Adhesion, Proliferation, and Migration by Modulating Membrane F…
2011
The disintegrin-metalloproteinases ADAM10 and ADAM17 mediate the release of several cell signaling molecules and cell adhesion molecules such as vascular endothelial cadherin or L-selectin affecting endothelial permeability and leukocyte transmigration. Dysregulation of ADAM activity may contribute to the pathogenesis of vascular diseases, but the mechanisms underlying the control of ADAM functions are still incompletely understood. Atherosclerosis is characterized by lipid plaque formation and local accumulation of unsaturated free fatty acids (FFA). Here, we show that unsaturated FFA increase ADAM-mediated substrate cleavage. We demonstrate that these alterations are not due to genuine ch…
Strain-Promoted Cycloaddition of Cyclopropenes with o-Quinones : A Rapid Click Reaction
2018
Abstract Novel click reactions are of continued interest in fields as diverse as bio‐conjugation, polymer science and surface chemistry. Qualification as a proper “click” reaction requires stringent criteria, including fast kinetics and high conversion, to be met. Herein, we report a novel strain‐promoted cycloaddition between cyclopropenes and o‐quinones in solution and on a surface. We demonstrate the “click character” of the reaction in solution and on surfaces for both monolayer and polymer brush functionalization.
Pulmonary surfactant protein C containing lipid films at the air-water interface as a model for the surface of lung alveoli.
1995
The pulmonary surfactant lines as a complex monolayer of lipids and proteins the alveolar epithelial surface. The monolayer dynamically adapts the surface tension of this interface to the varying surface areas during inhalation and exhalation. Its presence in the alveoli is thus a prerequisite for a proper lung function. The lipid moiety represents about 90% of the surfactant and contains mainly dipalmitoylphosphatidylcholine (DPPC) and phosphatidylglycerol (PG). The surfactant proteins involved in the surface tension adaption are called SP-A, SP-B and SP-C. The aim of the present investigation is to analyse the properties of monolayer films made from pure SP-C and from mixtures of DPPC, DP…