Search results for "Lead"

showing 10 items of 1360 documents

Pyrrolo[2,3-h]quinolinones: A new ring system with potent photoantiproliferative activity

2006

A new class of compounds, the pyrrolo[2,3-h]quinolin-2-ones, nitrogen isosters of the angular furocoumarin Angelicin, was synthesized with the aim of obtaining new photochemotherapeutic agents with increased antiproliferative activity and lower undesired toxic effects than the lead compound. Two synthetic pathways were approached to allow the isolation both of the dihydroderivatives 10-17 and of the aromatic ring system 23. Compounds 10-17 showed a remarkable phototoxicity and a great UVA dose dependence reaching IC(50) values at submicromolar level. Intracellular localization of these compounds has been evaluated by means of fluorescence microscopy using tetramethylrhodamine methyl ester a…

Ultraviolet RaysStereochemistryFibrosarcomaClinical BiochemistryPharmaceutical ScienceHL-60 CellsAdenocarcinomaQuinolonesBiochemistryChemical synthesisMass Spectrometrychemistry.chemical_compoundAngelicinangelicinDrug DiscoverymedicineHumansMolecular BiologyChromatography High Pressure LiquidCell ProliferationFluorescent DyesPhotosensitizing AgentsRhodaminesChemistryFurocoumarinErythrocyte MembraneOrganic ChemistryAcridine orangeProteinsDNAAcridine OrangeIntercalating AgentsMitochondriapyrroloquinolinoneCross-Linking ReagentsMicroscopy FluorescencePhotochemotherapyMechanism of actionMolecular MedicineLipid Peroxidationmedicine.symptomantitumour activityLysosomesPhototoxicityLead compoundDNA DamageMacromolecule
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EPPS16 - First nuclear PDFs to include LHC data

2017

We present results of our recent EPPS16 global analysis of NLO nuclear parton distribution functions (nPDFs). For the first time, dijet and heavy gauge boson production data from LHC proton-lead collisions have been included in a global fit. Especially, the CMS dijets play an important role in constraining the nuclear effects in gluon distributions. With the inclusion of also neutrino-nucleus deeply-inelastic scattering and pion-nucleus Drell-Yan data and a proper treatment of isospin-corrected data, we were able to free the flavor dependence of the valence and sea quark nuclear modifications for the first time. This gives us less biased, yet larger, flavor by flavor uncertainty estimates. …

Uncertainty estimates Uncertainty analysisHigh Energy Physics::LatticeLead collisionsNuclear TheoryHigh Energy Physics::PhenomenologyFOS: Physical sciencesNuclear parton distribution functions114 Physical sciencesHigh Energy Physics - ExperimentHigh Energy Physics - PhenomenologyHigh Energy Physics - Experiment (hep-ex)High Energy Physics - Phenomenology (hep-ph)Production dataHigh Energy Physics::ExperimentNuclear modificationNuclear ExperimentNuclear effectsBosonsDistribution functionsGlobal analysisInelastic scattering Deeply inelastic scatterings
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Leadership all’Università

2022

A partire da una riflessione teorica sul tema della leadership dei docenti universitari chiamati a ricoprire ruoli di responsabilità, il volume approfondisce le principali caratteristiche che dovrebbero avere i leader universitari di oggi, garanti dello sviluppo e della crescita del mondo accademico. Lo scopo del volume è di far riflettere sulle modalità che le Università possono adottare strategicamente per identificare forme di talento di leadership accademica e promuovere lo sviluppo della leadership universitaria. Nei primi due capitoli sono illustrate le diverse posizioni sul tema della leadership universitaria, vengono definite le qualità della leadership all’Università, delineate le …

University leadership teacher leadership Teacher Leadership USettore M-PED/04 - Pedagogia Sperimentale
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Contingent reward leader behaviour: Where does it come from?

2010

As many academics have pointed out, while researchers have learned a great deal about the effects of contingent reward (CR) leader behaviour, relatively little is known about its genesis. CR transactional leadership is traditionally viewed as an independent variable which exerts influence downstream. However, if we are to understand how to influence, improve or modify these downstream effects, we need to shift our focus upstream towards the study of transactional leadership as a dependent variable. In line with this reasoning, we put forward the hypothesis that a contextual variable (organizational learning capability) and a subordinate's characteristic (employability) are antecedents of CR…

Upstream (petroleum industry)Information Systems and ManagementVariablesbusiness.industryStrategy and Managementmedia_common.quotation_subjectGeneral Social SciencesSample (statistics)EmployabilityTransactional leadershipContextual variableOrganizational learningbusinessPsychologySocial psychologyDownstream (petroleum industry)media_commonSystems Research and Behavioral Science
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Dilemmaer i skandinavisk korlederutdanning

2021

Within higher education, programmes in choral conducting are offered of varying kinds and at different levels, from dedicated programmes to single courses that are embedded in other music programmes. The choral practice field is varied; choral leadership is partly a generic music competence and partly a profession. The variety and social reach of the choral movement suggest that the educational offering in choral conducting should be manifold in type and quantity in order to supply the practice field with qualified conductors. n this chapter we take a renewed look at material from three previous studies: (1) a mapping of Scandinavian choral leader education, based on document analysis and i…

VDP::Humaniora: 000::Musikkvitenskap: 110Mixed methodsKorledelseHøyere utdanningMusikkpedagogikkHigher educationKordirigenterChoral leadershipsBlandete metoderMusic educationChoral conductors
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Interaction model: Reflexiv leadership in the face of tensions in the school’s practical day to day handling

2023

Author's accepted manuscript Rektorer opplever utfordringer i det å arbeide som faglig, pedagogisk og administrativt ansvarlig på skolen. Faglig, pedagogisk og administrativt hensyn kan fort komme i konflikt med hverandre og skape spenninger i rektors arbeid. Denne artikkelen undersøker rektorenes opplevelse av å være leder på skolen, og hvordan de kan håndtere disse spenningene. For å komme så nære rektorene som mulig er det benyttet reflektive livsverdensintervjuer. Resultater i denne artikkelen støtter tidligere resultater i nordisk forskning om at administrative oppgaver tar fokus bort fra utviklingsoppgaver og at det er spenninger mellom ulike oppgaver i rektors arbeid. For å illustrer…

VDP::Samfunnsvitenskap: 200::Pedagogiske fag: 280::Andre pedagogiske fag: 289School managementInstructional LeadershipAdministrationSkoleledelseHeadteacher's RoleAdministrasjonGeneral MedicineRektors rollePedagogisk ledelseNorsk pedagogisk tidsskrift
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Crowdfunding in China: Turmoil of Global Leadership

2020

AbstractThis chapter offers a comprehensive review and explanation of crowdfunding in China. It first extensively describes the status of crowdfunding in China by presenting the market facts, insights, and current regulations of the four main crowdfunding models (reward-based, equity-based, loan-based, and donation-based) respectively. Next, through a detailed up-to-date literature review of the key literature of Chinese crowdfunding, three main research streams are summarized and discussed covering success drivers, comparative studies of Chinese versus other contexts of crowdfunding practice, and applications of crowdfunding for creative and sustainability projects. Finally, both practical…

VDP::Samfunnsvitenskap: 200::Økonomi: 210Political scienceSustainabilityGlobal LeadershipEquity crowdfundingMarket developmentMarketingChina
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The Road to Higher Prices: Will Improved Road Standards Lead to Higher Housing Prices?

2020

AbstractWe study the impact of improved road standards on housing prices in a region of Southern Norway, where towns are located along the coast, like pearls on a string, with sparsely populated areas between the towns. In this region towns have since long been linked together by a road, but in 2009 a new highway, roughly parallel to the old road, was opened. The new highway runs Eastwards from the main town in the region and reduced one-way commutes to the main town by 10–15 min. We examine how this change in transportation infrastructure has affected housing prices, using difference-in-difference regressions to identify the impact of the new highway. Three smaller towns located East of th…

VDP::Samfunnsvitenskap: 200::Økonomi: 210Urban StudiesEconomics and EconometricsLead (geology)business.industryAccountingCapital (economics)businessTransportation infrastructureFinanceFinancial servicesDifference in differencesAgricultural economicsThe Journal of Real Estate Finance and Economics
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Līderis kā vērtību nesējs

2016

Neskatoties, ka līderības fenomens jau ir bijis pētīts un aprakstīts zinātniskajos darbos, šis darbs atšķiras ar to, ka darba ietvaros tiek izmantots kvalitatīvais petījums ar ekspertiem, kas ir četri Latvijas valsts prezidenti – trīs bijušie un pašreizējais Valsts prezidents. Līdz ar to darbs ir unikāls ar to, ka apvieno vienuviet esošā Latvijas prezidenta un bijušo prezidentu viedokli un uzskatus par to, kas ir līderis, politiskais līderis un ko nozīmē būt valsts līderim. Darbā autore izmanto asociatīvo metodi un ekspertu intervijas. Darbs sastāv no divām daļām – teorētiskās un empīriskās daļas. Teorētiskajā daļā tiek aplūkots līdera, politiskā līdera, līderības jēdziens, līderu tipi, kād…

Vadībzinātneleadershiplīderībavērtībalīdersleader
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Līderība Salaspils novada sociālā dienesta organizācijas kultūras kontekstā.

2016

Zinot to, ka organizācijas kultūra ietekmē organizācijas darbības efektivitāti un spēj to uzlabot vai gluži pretēji degradēt, organizācijas vadītāji aizvien biežāk iesaistās organizācijas kultūras jautājumu izpēte un sakārtošanā. Šis process vērtējams profesionāli un pozitīvi ar mērķi aizvien labāk izprast organizācijas vērtības, kas šajā gadījuma ir cilvēkresursi un stimulēt darba efektivitātes pilnveidi. Agneses Belomestnajas maģistra darbs „Līderība Salaspils novada sociālajā dienestā organizācijas kultūras kontekstā” mērķis ir balstoties uz teorētiskās literatūras un iegūto datu analīzi, izpētīt līderības pilnveides iespēja organizācijā „Salaspils novada sociālais dienests”. Pētījuma re…

Vadībzinātneorganizācijas kultūraleadershiplīderībaOCAIOrganization’s culture
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