Search results for "Lease"
showing 10 items of 886 documents
Lipid nanocarriers containing sorafenib inhibit colonies formation in human hepatocarcinoma cells
2015
Here, the potential of two nanostructured lipid carriers (NLC) for controlled release of sorafenib was evaluated. The obtained systems showed characteristics suitable as drug delivery systems for the treatment of hepatocellular carcinoma (HCC) through parenteral administration. The use of a mixture between a solid lipid (tripalmitin) with a liquid lipid (Captex 355 EP/NF or Miglyol 812) to prepare NLC systems could give a higher drug loading capacity and a longer term stability during storage than that obtained by using only solid lipids. The obtained nanoparticles showed a nanometer size and high negative zeta potential values. Scansion electron microscopy (SEM) of the sorafenib loaded NLC…
Ursolic acid from the Chinese herb Danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells
2007
Danshen, the dried root of Salvia miltiorrhiza Bunge (Lamiaceae), is one of the most commonly used traditional Chinese medicines for cardiovascular indications. In EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVEC), an aqueous extract of danshen, and also a methanol extract of the plant, increased eNOS promoter activity, eNOS mRNA and protein expression, as well as endothelial NO production. A dichloromethane extract, in contrast, did not change eNOS gene expression. Thus, the active danshen constituent(s) responsible for eNOS upregulation is (are) hydrophilic and/or alcohol-soluble. One such compound is ursolic acid that significantly increased eNOS ex…
Tritium release behavior of beryllium pebbles after neutron irradiation between 523 and 823K
2013
Abstract Post-irradiation tritium release from the Pebble Bed Assembly (PBA) neutron-irradiated beryllium (Be) pebbles (∅ ≈ 1 mm; the total tritium inventory 2–4 GBq/g) was investigated on annealing in He + 0.1% H 2 . Temperature ramps of 2.3 K/min followed by annealing for 1 h at 1310–1320 K resulted in complete detritiation of the PBA Be pebbles. The tritium burst release occurred after a time lag of 1–6.5 h during constant temperature anneals at 1089–1180 K, with the release time measured after reaching the annealing temperature. Tritium burst release was also observed to occur during cool down. Anneals at 1089 K for 8 h and at 1045 K for 23 h caused detritiation of the PBA Be pebbles by…
Tritium release from beryllium articles for use in fusion devices
2009
Abstract Results obtained on radiation and magnetic field (MF) effects on tritium release at annealing of the beryllium pebbles from the EXOTIC-8-3/13 irradiation are presented in this study and compared with those for other irradiated beryllium materials. Abundance ratios of chemical forms of tritium in the EXOTIC-8-3/13 beryllium pebbles were determined: T 2 – 65%, T 0 – 23%, T + – 12%. A complete detritiation of these pebbles was achieved at 1123 K for 240 min; MF of 2.35 T had no appreciable effect on the tritium release. At 991 K for 240 min, the degree of detritiation was 96.6% without MF; MF of 2.35 T decreased it to 86.7%. At 940 K for 47 min, the degree of detritiation was 60%, 5 M…
TRITIUM RELEASE CHARACTERISTICS OF NEUTRON-IRRADIATED REFERENCE BERYLLIUM PEBBLES FOR THE HELIUM COOLED PEBBLE BED (HCPB) BLANKET
2011
In this paper, we present results on tritium release from the beryllium pebbles irradiated for 294 full power days from 17 April 2003 to November 2004 to the neutron fluence of 1.5-2 × 1025 m-2 (E>...
Aurintricarboxylic acid as a nuclease inhibitor in fungal protoplasts
1986
Aurintricarboxylic acid (ATA), a potent nuclease inhibitor, has been shown to prevent foreign DNA degradation in transformation of Penicillium chrysogenum and Saccharomyces cerevisiae. ATA may be useful not only in vitro but also in vivo.
(1,3,4‐Oxadiazole)copper(II) Compounds: Dimensionality, Magnetism and Nuclease Activity
2009
The work presented here describes the synthesis of new copper(II) complexes derived from 2-amino-5-(pyridin-2-yl)-1,3,4-oxadiazole (L1) and 2-methylamino-5-(pyridin-2-yl)-1,3,4-oxadiazole (L2) which also incorporate azido (N3 -), thiocyanato (NCS-), cyanato (NCO-), dicyanamido [N(CN)2 -, dca] and malonato (C3H2O4 2-, mal) coligands. Structures of the [Cu(L2)(mal)(H2O)]·2H 2O(1), [{Cu(L2)(mal)}2] (2), [Cu(L 2)2-(NCS)2] (3), [Cu(L1)(NCS) 2]n (4) and [{Cu(L2)}2(dca) 2](ClO4)2·2H2O (5) compounds show the dependence of the dimensionality on parameters such as the type of oxadiazole and coligand utilised, solvents or reaction times. In this sense, 1 and 3 are mononuclear complexes, 2 contains cen…
Structural characterisation and nuclease activity of mixed copper(II) complexes with sulfonamides and bipyridil
2003
Mixed copper complexes have been synthetised through reaction of Cu(II) salts with bipyridil and N-quinolin-8-yl-p-toluenesulfonamide (Hqtsa), N-quinolin-8-yl-benzenesulfonamide (Hqbsa) or N-quinolin-8-yl-naftalenesulfonamide (Hqnsa). Single crystal X-ray diffraction structure determination shows that copper cations are five-coordinated, one complex have distorted bipyramidal trigonal geometry and the other have a distorted square-pyramid. The FT IR and EPR spectra are also reported. Electrophoresis results show that the synthetised complexes in the presence of ascorbate and hydrogen peroxide are chemical nucleases.
Acetylated nucleosome assembly on telomeric DNAs
2003
Abstract The role of histone N-terminal domains on the thermodynamic stability of nucleosomes assembled on several different telomeric DNAs as well as on ‘average’ sequence DNA and on strong nucleosome positioning sequences, has been studied by competitive reconstitution. We find that histone tails hyperacetylation favors nucleosome formation, in a similar extent for all the examined sequences. On the contrary, removal of histone terminal domains by selective trypsinization causes a decrease of nucleosome stability which is smaller for telomeres compared to the other sequences examined, suggesting that telomeric sequences have only minor interactions with histone tails. Micrococcal nuclease…
Retention-release equilibrium of aroma compounds in polysaccharide gels: study by quantitative structure-activity/property relationships approach
2010
The nature and amount of constituents in food greatly influence aroma release. Pectins and carrageenans are common used thickeners, but their effect on the release of aroma compounds has been studied more frequently for non- homogeneous products than for thickeners separately. The purpose of this work was to study and compare their respective effects in simple model systems. In this way, the release of 13 aroma compounds was analysed by headspace analysis at equilibrium in pure water, i-carrageenan and pectin gels. To evaluate the influence of the chemical structure of aroma com- pounds on retention/release equilibrium between vapour phase and gels, we used a quantitative structure-activity…