Search results for "Lease"

AMPHIPHILIC GRAFT COPOLYMER OF HYALURONIC ACID AND POLYLACTIC ACID FOR PULMONARY DELIVERY OF AMPHOTERICIN B

2009

Novel Drug Delivery System for Treatment-Resistant Schizophrenia

2021

La denitrificazione biologica delle acque di falda: studio di tre differenti substrati organici

2015

L’uso massiccio di fertilizzanti contenenti azoto è causa dei fenomeni di inquinamento diffuso delle acque di falda. In tale ottica, notevole interesse hanno recentemente riscosso i trattamenti biologici in situ, in grado di promuovere la denitrificazione delle acque di falda mediante la realizzazione di interventi che coniugano efficacia di rimozione e costi relativamente contenuti. Nella nota si riportano i risultati di una ricerca sul processo di denitrificazione eterotrofa, condotta utilizzando come fonte di carbonio tre materiali convenzionalmente considerati di scarto: corteccia di pino, sughero e sansa di olive. Lo studio è stato suddiviso in due fasi: la prima condotta in modalità b…

Green composites for fertilizer controlled release produced by compression molding and FDM

2023

Excessive fertilization causes ecological problems due to leaching issues. To solve this problem and promote agriculture sustainability an innovative green composite for controlled release fertilizers was produced by adding NPK fertilizer flour to a biodegradable polymer with or without Opuntia Ficus Indica (OFI) particles. Six formulations were produced and employed for the fabrication of devices both for compression molding (CM) and fused deposition modeling (FDM). Both fillers displayed a good dispersion in the composites, excellent adhesion with the polymeric matrix and effectively acted as reinforcement. The decrease of NPK release rate (up to 30 days) was achieved using whole composit…

Lactate level and handgrip test in migraine and fibromyalgia after self-myofascial release treatment

2019

The Aim of the study was to determine the effect of self-myofascial release (SMFR) treatment on handgrip test score in patients with fibromyalgia and migraine, investigating also if the lactate levels influenced the result. Twenty-five subjects affected by migraine (age 49.7±12.5; height 164.9±6.62 cm; weight 68.6±16.9 kg) and ten subjects affected by fibromyalgia (age 43.7±21.2; height 158±5.65 cm; weight 70±28.9 kg) were enrolled in the study. The assessments included a handgrip test, in order to evaluate isometric strength of both hands and forearm muscles and the lactate levels evaluation. The treatment was performed in the three most painful trigger points indicated from subjects as to…

Rat CNS neurons are not yet programmed to shorten their chromatin repeat length at the end of fetal neurogenesis.

1986

Neurons from rat fetal cerebral hemispheres were grown in a synthetic medium (Maat medium), as previously described, for different periods of time. The repeat length of their chromatin was determined by micrococcal nuclease digestion and compared with that of neurons isolated from postnatal rat brain of corresponding ages. In contrast to the in vivo situation, we found that neurons, dissociated at the 16th gestational day and cultured in vitro, did not undergo the shortening of their chromatin repeat, thus indicating that, at the end of their mitotic cycles, they are not yet programmed to this event. © 1986.

Multicomponent Antibiofilm Lipid Nanoparticles as Novel Platform to Ameliorate Resveratrol Properties: Preliminary Outcomes on Fibroblast Proliferati…

2023

The well-being of skin and mucous membranes is fundamental for the homeostasis of the body and thus it is imperative to treat any lesion quickly and correctly. In this view, polyphenols might assist and enhance a successful wound healing process by reducing the inflammatory cascade and the production of free radicals. However, they suffer from disadvantageous physico–chemical properties, leading to restricted clinical use. In this work, a complex mixture of PEGylated lipid, Glyceryl monoester, 18-β-Glycyrrhetinic Acid and Menthol was designed to entrap Resveratrol (RSV) as the active ingredient and further produce lipid nanoparticles (LNPs) by homogenization followed by high-freq…

miRNA Signature and Dicer Requirement during Human Endometrial Stromal Decidualization In Vitro

2012

Decidualization is a morphological and biochemical transformation of endometrial stromal fibroblast into differentiated decidual cells, which is critical for embryo implantation and pregnancy establishment. The complex regulatory networks have been elucidated at both the transcriptome and the proteome levels, however very little is known about the post-transcriptional regulation of this process. miRNAs regulate multiple physiological pathways and their de-regulation is associated with human disorders including gynaecological conditions such as endometriosis and preeclampsia. In this study we profile the miRNAs expression throughout human endometrial stromal (hESCs) decidualization and analy…

Enzyme-responsive intracellular-controlled release using silica mesoporous nanoparticles capped with ε-poly-L-lysine.

2014

The synthesis and characterization of two new capped silica mesoporous nanoparticles for controlled delivery purposes are described. Capped hybrid systems consist of MCM-41 nanoparticles functionalized on the outer surface with polymer epsilon-poly-L-lysine by two different anchoring strategies. In both cases, nanoparticles were loaded with model dye molecule [Ru(bipy)(3)](2+). An anchoring strategy involved the random formation of urea bonds by the treatment of propyl isocyanate-functionalized MCM-41 nanoparticles with the lysine amino groups located on the epsilon-poly-L-lysine backbone (solid Ru-rLys-S1). The second strategy involved a specific attachment through the carboxyl terminus of…

Protein delivery based on uncoated and chitosan-coated mesoporous silicon microparticles

2011

Mesoporous silicon is a biocompatible, biodegradable material that is receiving increased attention for pharmaceutical applications due to its extensive specific surface. This feature enables to load a variety of drugs in mesoporous silicon devices by simple adsorption-based procedures. In this work, we have addressed the fabrication and characterization of two new mesoporous silicon devices prepared by electrochemistry and intended for protein delivery, namely: (i) mesoporous silicon microparticles and (ii) chitosan-coated mesoporous silicon microparticles. Both carriers were investigated for their capacity to load a therapeutic protein (insulin) and a model antigen (bovine serum albumin) …