Search results for "Lep"
showing 10 items of 3622 documents
Enhanced tonic GABAA inhibition in typical absence epilepsy
2009
The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but impaired γ-aminobutyric acid (GABA)-ergic inhibition remains an attractive hypothesis. In contrast, we show here that extrasynaptic GABAA receptor–dependent 'tonic' inhibition is increased in thalamocortical neurons from diverse genetic and pharmacological models of absence seizures. Increased tonic inhibition is due to compromised GABA uptake by the GABA transporter GAT-1 in the genetic models tested, and GAT-1 is crucial in governing seizure genesis. Extrasynaptic GABAA receptors are a requirement for seizures in two of the best character…
The inhibitory neural circuitry as target of antiepileptic drugs.
2001
Impairments and defects in the inhibitory neurotransmission in the CNS can contribute to various seizure disorders, i.e., gamma-aminobutyric acid (GABA) and glycine as the main inhibitory neurotransmitters in the brain play a crucial role in some forms of epilepsy. Recent advances in deciphering the molecular basis of the GABAergic and glycinergic systems has been achieved by means of cloning techniques and gene targeting strategies in animals, contributing to the understanding of drug action. As well, several anticonvulsive substances emerged which target key molecules of the inhibitory systems. Employment of recombinant expression systems, including, but not restricted to the inhibitory c…
Lack of SCN1A Mutations in Familial Febrile Seizures
2002
Summary: Purpose: Mutations in the voltage-gated sodium channel subunit gene SCN1A have been associated with febrile seizures (FSs) in autosomal dominant generalized epilepsy with febrile seizures plus (GEFS+) families and severe myoclonic epilepsy of infancy. The present study assessed the role of SCN1A in familial typical FSs. Methods: FS families were selected throughout a collaborative study of the Italian League Against Epilepsy. For each index case, the entire coding region of SCN1A was screened by denaturant high-performance liquid chromatography. DNA fragments showing variant chromatograms were subsequently sequenced. Results: Thirty-two FS families accounting for 91 affected indiv…
Alteraciones en la homeostasis del transportador de glutamato GLT-1 en la Enfermedad de Lafora
2017
Tesis doctoral, 192 páginas, figuras y tablas
Study of elementary reactions with the hades dielectron spectrometer
2010
Results obtained with the HADES dielectron spectrometer at GSI are discussed, with emphasis on dilepton production in elementary reactions. Díaz Medina, José, Jose.Diaz@uv.es ; Gil Ortiz, Alejandro, Alejandro.Gil@ific.uv.es
New records of gall-inducer and inquiline insects in a few mediterranean countries, with biological notes
2014
An annotated list of some gall-inducing and inquiline insects found on herbaceous plants and trees in Italy and in other few Mediterranean countries is reported. Among the gall-inducer species, Phanacis phoenixopodos (Mayr, 1882) is new for the Italian peninsula, Callirhytis rufescens (Mayr, 1882), Andricus quercusramuli (L., 1761) and Plagiotrochus amenti Kieffer, 1901 (Cynipidae: Hymenoptera) are new for Sicily; the latter was previously cited from Italy without collecting data. Oecocecis guyonella Guenée, 1870 was found in Libya and Amblypalpis olivierella Ragonot, 1886 (Gelechiidae: Lepidoptera) in Jordan, Libya, Northern Yemen, and the United Arab Emirates. In addition, Saphonecrus gal…
Teleportation of squeezing: optimization using non-Gaussian resources
2010
We study the continuous-variable quantum teleportation of states, statistical moments of observables, and scale parameters such as squeezing. We investigate the problem both in ideal and imperfect Vaidman-Braunstein-Kimble protocol setups. We show how the teleportation fidelity is maximized and the difference between output and input variances is minimized by using suitably optimized entangled resources. Specifically, we consider the teleportation of coherent squeezed states, exploiting squeezed Bell states as entangled resources. This class of non-Gaussian states includes photon-added and photon-subtracted squeezed states as special cases. At variance with the case of entangled Gaussian re…
Tunable non-Gaussian resources for continuous-variable quantum technologies
2013
We introduce and discuss a set of tunable two-mode states of continuous-variable systems, as well as an efficient scheme for their experimental generation. This novel class of tunable entangled resources is defined by a general ansatz depending on two experimentally adjustable parameters. It is very ample and flexible as it encompasses Gaussian as well as non-Gaussian states. The latter include, among others, known states such as squeezed number states and de-Gaussified photon-added and photon-subtracted squeezed states, the latter being the most efficient non-Gaussian resources currently available in the laboratory. Moreover, it contains the classes of squeezed Bell states and even more ge…
Analysis of myxoma virus genome using pulsed-field gel electrophoresis
1996
A method is presented for the isolation of large quantities of myxoma virus DNA using pulsed-field gel electrophoresis (PFGE), and some preliminary applications of this technique.
Horizontally transmitted parasitoid killing factor shapes insect defense to parasitoids
2021
Protection from parasitism by a virus Parasitoid wasps have developed myriad systems to overcome the defense mechanisms of their hosts as they lay their eggs in the bodies and eggs of targeted species. Gasmi et al . report how the host can fight back when infected by a virus that expresses a protein conferring resistance to the parasitoid. When members of the butterfly and moth family are targeted by wasps, a protein family has evolved that is horizontally carried by viruses—and sometimes is incorporated into the host genome—and impairs the ability of parasitoid offspring to fully develop and emerge. Characterizing the ability of this protein to protect hosts against specific parasites, the…