Search results for "Library"
showing 10 items of 3069 documents
Selective Inhibition of STAT3 with Respect to STAT1: Insights from Molecular Dynamics and Ensemble Docking Simulations
2016
STAT3 protein, which is known to be involved in cancer development, is a promising target for anticancer therapy. Successful inhibitors of STAT3 should not affect an activity of closely related protein STAT1, which makes their development challenging. The mechanisms of selectivity of several existing STAT3 inhibitors are not clear. In this work, we studied molecular mechanisms of selectivity of 13 experimentally tested STAT3 inhibitors by means of extensive molecular dynamics and ensemble docking simulations. It is shown that all studied inhibitors bind to the large part of the protein surface in an unspecific statistical manner. The binding to the dimerization interface of the SH2 domain, …
A Multivariate Analysis of HIV-1 Protease Inhibitors and Resistance Induced by Mutation
2005
This paper describes the use of the multivariate statistical procedure principal component analysis as a tool to explore the inhibitory activity of classes of protease inhibitors (PIs) against HIV-1 viruses (wild type and more-frequent single mutants, V82A, V82F, and I84V) and against protease enzymes. The analysis of correlations between biological activity and molecular descriptors or similarity indexes allowed a reliable classification of the 51 derivatives considered in this study. The best results were obtained in the case of the I84V mutant for which a high number of predictions was achieved. On this basis, this statistical approach is proposed as a reliable method for the prediction …
Molecular cloning and characterization of a Candida albicans gene coding for cytochrome c haem lyase and a cell wall-related protein.
1998
Immunoscreening of a Candida albicans cDNA library with a monoclonal antibody (mAb 4C12) recognizing an epitope present in high-molecular-weight mannoprotein (HMWM) components specific for the mycelial cell walls (a 180 kDa component and a polydispersed 260 kDa species) resulted in the isolation of the gene CaCYC3 encoding for cytochrome c haem lyase (CCHL). The CaCYC3 gene was transcribed preferentially in mycelial cells in which two mRNA transcripts of 0.8 and 1 kb were found. The nucleotide and the deduced amino acid sequences of this gene displayed 45% homology and 46% identity, respectively, to the Saccharomyces cerevisiae CYC3 gene and shared common features with other reported genes …
Les soubassements religieux de la vulgarisation scientifique dans la France du XIXè siècle
2014
International audience
Understanding eParticipation services in indonesian local government
2014
Published version of a chapter in the book: Information and Communication Technology. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-642-55032-4_32 This study aims at understanding how local government from a developing country, in this case Indonesia, implement and manage eParticipation services. In doing so, we combine institutional theory and stakeholder theory to build a sharper analytical lens. From an interpretive case study in the city of Yogyakarta, we reveal the institutionalization process of the services since their inception and identify major stakeholders and their salience. Based on our findings, we propose implications for practice and suggest implicati…
Oral toxicity produced by chemotherapy: A systematic review
2014
Introduction: Antineoplastic chemotherapy remains one of the most widely used management strategies in cancer, either alone or in combination with other types of treatment. The main inconvenience of chemotherapy is its lack of selectivity, since it acts upon both tumor cells and rapidly multiplying normal cells such as bone marrow cells, hair follicle cells and oral and gastrointestinal mucosal cells. Material and method: An exhaustive search was made of the main oral toxic effects of chemotherapy in the PubMed-Medline, Cochrane Library and Scopus databases. A total of 1293 articles were identified, of which 333 met the study inclusion criteria. Results: The toxic effects of chemotherapy at…
De Novo Assembly and Functional Annotation of the Olive (Olea europaea) Transcriptome
2013
Olive breeding programmes are focused on selecting for traits as short juvenile period, plant architecture suited for mechanical harvest, or oil characteristics, including fatty acid composition, phenolic, and volatile compounds to suit new markets. Understanding the molecular basis of these characteristics and improving the efficiency of such breeding programmes require the development of genomic information and tools. However, despite its economic relevance, genomic information on olive or closely related species is still scarce. We have applied Sanger and 454 pyrosequencing technologies to generate close to 2 million reads from 12 cDNA libraries obtained from the Picual, Arbequina, and L…
Info-communicationnal approach of medical cannabis self-medication : analysis of figures mobilized in knowledge legitimation within a community dedic…
2022
This thesis proposes an infocommunicational approach to self-medication with medical cannabis. We question the logic of knowledge legitimization in a context where the coercive power of the French state is exercised. We seek to understand how the use of cannabis is determined in a radically constrained legislative framework, for users in a recreational or self-medication approach, but also for doctors and patients in a medical approach. To do this, we analyze the processes of knowledge legitimization that allow the development of practical know-how allowing individuals to consume cannabis in a self-medication approach within clandestine health communities of practice, supported by participa…
Obesity and food, discours and practices communication approach
2022
It is within the framework of Information and Communication Sciences that our study proposes to analyze the communicational approach of obesity and diet to highlight how discourse influences eating practices. By relying on the study of scientists discourses, experts, health and food professionals and on that of the messages delivered by educators to the wide public, we try to determine why the innumerable recommendations generate in those who receive them, process them, interpret them, confusion or even misunderstanding. However, these are not the sources of information that are lacking to keep abreast of advances in medical science, innovations or progress proposed by Agro-industrials. Arg…
Les archives hospitalières
2016
National audience; Les archivistes hospitaliers sont confrontés à de nombreux défis : dématérialisation, normalisation, traitement et valorisation des archives. D'un autre côté, les juristes doivent démêler les règles applicables, partagées entre le Code de la santé publique et le Code du patrimoine, mais aussi veiller à la protection des droits des patients. Le législateur et le juge assurent un arbitrage entre ces droits. Ces archives procurent de riches sources d'information pour retracer l'histoire de la médecine celle du droit de la famille et de la protection sociale. Elles donnent accès à des pans entier de l'histoire sociale.