Search results for "Linear Models"

showing 10 items of 440 documents

Development and validation of a liquid chromatography tandem mass spectrometry method for the analysis of beta-agonists in animal feed and drinking w…

2010

A reproducible, sensitive and selective multiresidue analytical method for seven beta-agonists: clenbuterol (CBT), clenpenterol (CPT), ractopamine (RTP), brombuterol (BBT), mabuterol (MBT), mapenterol (MPT), and hydroxymethylclenbuterol (HMCBT) was developed and validated by using liquid chromatography tandem mass spectrometry (LC-MS/MS) in feed and drinking water samples. The validation was achieved according to the criteria laid down in the Commission Decision 2002/657/EC, however it was necessary to use minimum required performance limits (MRPLs) proposed by the Community Reference Laboratories (CRLs) due to the lack of maximum residue limits (MRLs) for beta-agonists. By setting up these…

Animal feedBiochemistryHigh-performance liquid chromatographySensitivity and SpecificityAnalytical Chemistrychemistry.chemical_compoundLiquid chromatography–mass spectrometryTandem Mass SpectrometryWater SupplyPhenethylaminesSample preparationResidue (complex analysis)ChromatographyMabuterolOrganic ChemistryReproducibility of ResultsWaterGeneral MedicineAdrenergic beta-AgonistsAnimal FeedRactopaminechemistryEthanolaminesLinear ModelsWater qualityChromatography LiquidJournal of chromatography. A

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QuBiLs-MAS method in early drug discovery and rational drug identification of antifungal agents

2015

The QuBiLs-MAS approach is used for the in silico modelling of the antifungal activity of organic molecules. To this effect, non-stochastic (NS) and simple-stochastic (SS) atom-based quadratic indices are used to codify chemical information for a comprehensive dataset of 2478 compounds having a great structural variability, with 1087 of them being antifungal agents, covering the broadest antifungal mechanisms of action known so far. The NS and SS index-based antifungal activity classification models obtained using linear discriminant analysis (LDA) yield correct classification percentages of 90.73% and 92.47%, respectively, for the training set. Additionally, these models are able to correc…

AntifungalQuantitative structure–activity relationshipAntifungal AgentsLinear discriminant analysismedicine.drug_classIn silicoAtom-based quadratic indicesQSAR modelQuantitative Structure-Activity RelationshipBioengineeringDrug developmentComputational biologyQuantitative structure activity relationVrtual screening antifungal agentDrug DiscoverymedicineComputer SimulationDrug identificationChemistryDrug discoveryLinear modelDiscriminant AnalysisGeneral MedicineLinear discriminant analysisCombinatorial chemistryChemistryTest setLinear ModelsMolecular MedicineQuBiLs-MAS softwareStatistical modelAntifungal agent

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The size of juxtaluminal hypoechoic area in ultrasound images of asymptomatic carotid plaques predicts the occurrence of stroke

2013

Abstract OBJECTIVE: To test the hypothesis that the size of a juxtaluminal black (hypoechoic) area (JBA) in ultrasound images of asymptomatic carotid artery plaques predicts future ipsilateral ischemic stroke. METHODS: A JBA was defined as an area of pixels with a grayscale value 10 mm(2) (P 8 mm(2)) was still significant after adjusting for other plaque features known to be associated with increased risk, including stenosis, grayscale median, presence of discrete white areas without acoustic shadowing indicating neovascularization, plaque area, and history of contralateral TIA or stroke. Plaque area and grayscale median were not significant. Using the significant variables (stenosis, discr…

Asymptomatic carotid plaqueMaleTime Factorsmedicine.medical_treatmentCarotid endarterectomyKaplan-Meier EstimateSeverity of Illness Indexasymptomatic carotid artery stenosis; hypoecoic area; StrokeRisk FactorsCarotid StenosisUltrasonography Doppler ColorProspective cohort studyStrokeAged 80 and overNeovascularization Pathologichypoecoic areaMiddle AgedPrognosisPlaque AtheroscleroticEuropeStrokeIschemic Attack TransientPredictive value of testsFemaleRadiologymedicine.symptomjuxtaluminal hypoechoic area ultrasound images asymptomatic carotid plaques strokeCardiology and Cardiovascular MedicineCarotid Artery InternalAdultmedicine.medical_specialtyAsymptomaticRisk AssessmentAsymptomatic carotid plaque; Brain ischemia; Stroke; EchographyBrain ischemiaPredictive Value of Testsasymptomatic carotid artery stenosimedicineHumanscardiovascular diseasesAgedProportional Hazards Modelsbusiness.industryProportional hazards modelmedicine.diseaseAcoustic shadowSettore MED/11 - Malattie Dell'Apparato CardiovascolareStenosisROC CurveAsymptomatic DiseasesLinear ModelsSurgeryasymptomatic carotid artery stenosisEchographybusinessFollow-Up Studies

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Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors After a Long-Term Follow-Up in the PREDI…

2016

Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases. However, accuracy and reliability of these studies may be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake. Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay in urine, is correlated with an improvement in cardiovascular risk factors (blood pressure and serum glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations) in an elderly population at high risk. A longitudinal study was performed with 573 participants (aged 67.3 ± 5.9) f…

Blood GlucoseMale0301 basic medicineAgingSistema cardiovascular -- MalaltiesBlood PressureUrine030204 cardiovascular system & hematologyBiochemistryGastroenterologychemistry.chemical_compound0302 clinical medicineRisk FactorsPolyphenols in urineLongitudinal StudiesCardiovascular risk factorsAged 80 and overBioquímica y tecnologíalcsh:CytologyConfoundingBiochemical markersGeneral MedicineMiddle AgedMetabolismeBiochemistry and technologyCholesterolCardiovascular diseasesCardiovascular DiseasesPolifenolsMarcadors bioquímicsBiomarker (medicine)FemaleColesterolResearch Articlemedicine.medical_specialtyArticle SubjectUrinary systemNutritional StatusBioquímica i biotecnologiaExcretion03 medical and health sciencesMediterranean cooking:Ciencias de la Salud::Medicina preventiva [Materias Investigacion]Medical statisticsInternal medicineCuina mediterràniamedicineMortalitatHumansFood consumptionlcsh:QH573-671MortalityLong-term follow-upTriglyceridesAged030109 nutrition & dieteticsTriglycerideCholesterolbusiness.industryMalalties cardiovascularsCholesterol HDLPolyphenolsPREDIMED studyCholesterol LDLFeeding BehaviorBiomarkerEffects of PolyphenolCell BiologyPressió arterial1942-0900Blood pressureMetabolismchemistryMultivariate AnalysisLinear ModelsbusinessEstadística mèdicaConsum d'alimentsBiomarkersFollow-Up StudiesOxidative Medicine and Cellular Longevity

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Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to th…

2012

Background: Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet). Methods: Case-control study in 7,052 high cardiovascular risk subjects (3,430 type 2 diabetes c…

Blood GlucoseMalelcsh:Diseases of the circulatory (Cardiovascular) systemmodelos logísticoscumplimiento del pacienteMediterranean dietEndocrinology Diabetes and MetabolismhumanosType 2 diabetesfrecuencia génicaMC4RDiet MediterraneanBody Mass IndexNutrigenomicsGene FrequencySurveys and QuestionnairesOdds Ratiomediana edadNutrigeneticsOriginal InvestigationAged 80 and overeducation.field_of_studyancianonutrigenómicaDiabetisdietamodelos linealesDiabetesayunodistribución de la ji al cuadradoFastingMiddle Agedcociente de probabilidades relativasestado nutricionalPhenotypeinteracción gen-ambientediabetes mellitusfenotipoReceptor Melanocortin Type 4FemaleDietaCardiology and Cardiovascular MedicineFTONutrigenòmicamedicine.medical_specialtyglucosa sanguíneaGene-diet interactionsPopulationestudios de casos y controlesAlpha-Ketoglutarate-Dependent Dioxygenase FTONutritional StatusDiabetes mellitusInternal medicineMediterranean dietmedicineGenetic predispositionHumansGenetic Predisposition to Diseaseanálisis multifactorialeducationAgedChi-Square DistributionPolymorphism Geneticbusiness.industryproteínasíndice de masa corporalCase-control studyProteinsnutritional and metabolic diseasespredisposición genética a la enfermedadmedicine.diseaseObesityDietEndocrinologyLogistic ModelsDiabetes Mellitus Type 2lcsh:RC666-701SpainCase-Control StudiesMultivariate AnalysisLinear ModelsPatient ComplianceGene-Environment InteractionbusinessBody mass index

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Validation of a mapping and prediction model for human fasciolosis transmission in Andean very high altitude endemic areas using remote sensing data.

2001

The present paper aims to validate the usefulness of the Normalized Difference Vegetation Index (NDVI) obtained by satellite remote sensing for the development of local maps of risk and for prediction of human fasciolosis in the Northern Bolivian Altiplano. The endemic area, which is located at very high altitudes (3800-4100 m) between Lake Titicaca and the valley of the city of La Paz, presents the highest prevalences and intensities of fasciolosis known in humans. NDVI images of 1.1 km resolution from the Advanced Very High Resolution Radiometer (AVHRR) sensor on board the National Oceanic and Atmospheric Administration (NOAA) series of environmental satellites appear to provide adequate …

BoliviaFascioliasisGeographic information systemAdvanced very-high-resolution radiometerVeterinary (miscellaneous)Normalized Difference Vegetation IndexRisk FactorsmedicinePrevalenceHumansFasciolosisbusiness.industryAltitudeEffects of high altitude on humansmedicine.diseaseSatellite CommunicationsField (geography)Infectious DiseasesGeographyRemote sensing (archaeology)Insect ScienceLinear ModelsParasitologySatellitebusinessCartographyActa tropica

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Influence of different biomaterials on the viability of Aggregatibacter actinomycetemcomitans

2011

Abstract Objectives The aim of the present in vitro study was to evaluate the effects of different biomaterials used for regenerative periodontal surgery on the growth of the periodontopathogen Aggregatibacter actinomycetemcomitans . Methods Three commercially available biomaterials of synthetic origin (hydroxyapatite/beta-tricalcium phosphate, nanostructured hydroxyapatite paste, oily calcium hydroxide suspension), a bovine-derived xenograft as well as an enamel matrix derivative (EMD) were added in different concentrations to calibrated suspensions of A. actinomycetemcomitans ATCC 43718/33384 (serotype b/c). Equal aliquots (0.1 ml) for the viability assay were taken after 5 min, 1 h, 3 h,…

Calcium PhosphatesBone MatrixBiocompatible MaterialsRegenerative MedicineAggregatibacter actinomycetemcomitansMicrobiologyCalcium HydroxideAgar platechemistry.chemical_compoundDental Enamel ProteinsMaterials TestingEnamel matrix derivativeAnimalsViability assayLeast-Squares AnalysisGeneral DentistryColony-forming unitMicrobial ViabilityCalcium hydroxidebiologyAggregatibacter actinomycetemcomitansCell BiologyGeneral Medicinebiology.organism_classificationAntimicrobialNanostructuresDurapatiteOtorhinolaryngologychemistryLinear ModelsCattleGrowth inhibitionArchives of Oral Biology

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Comparison between doppler-echocardiography and uncalibrated pulse contour method for cardiac output measurement. a multicenter observational study

2016

Objectives: Echocardiography and pulse contour methods allow, respectively, noninvasive and less invasive cardiac output estimation. The aim of the present study was to compare Doppler echocardiography with the pulse contour method MostCare for cardiac output estimation in a large and nonselected critically ill population. Design: A prospective multicenter observational comparison study. Setting: The study was conducted in 15 European medicosurgical ICUs. Patients: We assessed cardiac output in 400 patients in whom an echocardiographic evaluation was performed as a routine need or for cardiocirculatory assessment. Interventions: None. Measurements and Main Results: One echocardiographic car…

Cardiac outputgenetic structuresintensive care unitsBlood PressureDoppler echocardiographyCritical Care and Intensive Care Medicinearterial waveform analysis; cardiac output; Doppler echocardiography; echocardiography; hemodynamic monitoring; pulse contour method; Critical Care and Intensive Care Medicinehemodynamic monitoring0302 clinical medicine030202 anesthesiologyechocardiographyhumansarterial waveform analysisarterial waveform analysis; cardiac output; doppler echocardiography; echocardiography; hemodynamic monitoring; pulse contour method; heart; humans; intensive care units; linear models; monitoring; physiologic; prospective studies; blood pressure; cardiac output; echocardiography; doppler; pulse; critical care and intensive care medicinemedicine.diagnostic_testPulse (signal processing)physiologicblood pressureHeartEchocardiography Dopplercardiovascular systemCardiologysymbolsLinear ModelDoppler effectHumandoppler echocardiographymedicine.medical_specialtyIntensive Care UnitLess invasiveheartpulse contour methoddoppler03 medical and health sciencesCardiac output measurementsymbols.namesakeInternal medicinemedicinePulsearterial waveform analysiMonitoring Physiologicbusiness.industrycardiac output030208 emergency & critical care medicineDoppler echocardiographyprospective studiesProspective StudiemonitoringMulticenter studycritical care and intensive care medicineObservational studylinear modelsbusinesspulse

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Carotid atherosclerosis and chronic hepatitis C: A prospective study of risk associations

2011

BACKGROUND AND AIMS: There are contrasting results in studies of cardiovascular risk in patients with genotype 1 chronic hepatitis C (G1 CHC). We evaluated the prevalence of carotid atherosclerosis compared with a control population in order to assess the potential association between atherosclerosis, host and viral factors, and liver histological features. MATERIALS AND METHODS: One hundred seventy-four consecutive biopsy-proven G1 CHC patients were evaluated by anthropometric and metabolic measurements. One hundred seventy-four patients attending an outpatient cardiology unit were used as controls. Intima-media thickness (IMT) and carotid plaques, defined as focal thickening of > 1.3 mm a…

Carotid Artery DiseasesMaleLIVER BIOPSYComorbiditySeverity of Illness IndexGastroenterologyBody Mass IndexReference ValuesOdds RatioPrevalenceProspective StudiesProspective cohort studySettore MED/12 - Gastroenterologiamedicine.diagnostic_testBiopsy NeedleSmokingHepatitis CMiddle AgedPrognosisHCV ATHEROSCLEROSI FIBROSISImmunohistochemistryItalyCAROTID ATHEROSCLEROSISFemaleRadiologyAdultmedicine.medical_specialtySettore MED/08 - Anatomia PatologicaCHRONIC HEPATITIS CRisk AssessmentYoung AdultAge DistributionInternal medicineDiabetes mellitusBiopsyHEPATIC FIBROSISConfidence IntervalsmedicineHumansObesitySex DistributionAgedAnalysis of VarianceHepatologybusiness.industryCase-control studyUltrasonography DopplerOdds ratioHepatitis C ChronicHepatologymedicine.diseaseDiabetes Mellitus Type 2Case-Control StudiesMultivariate AnalysisLinear ModelsSteatosisbusinessHepatology

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Relationship between carotid intima-media thickness and non valvular atrial fibrillation type.

2015

OBJECTIVE: Carotid intima-media thickness (cIMT) is a surrogate marker of subclinical atherosclerosis and it is able to predict both coronary and cerebral vascular events. No data exist on the association between cIMT and non valvular atrial fibrillation (NVAF) type. We conduct this study with the aim to analyze the association between abnormal cIMT and NVAF type. METHODS: A cross-sectional study of the "Atrial fibrillation Registry for Ankle-brachial index Prevalence Assessment-Collaborative Italian Study (ARAPACIS)" has been performed. Among 2027 patients enrolled in the ARAPACIS, 673 patients, who underwent carotid ultrasound examination to assess cIMT, were included in the study. RESULT…

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