Search results for "Linear mixed model"
showing 10 items of 36 documents
Analyzing environmental‐trait interactions in ecological communities with fourth‐corner latent variable models
2021
In ecological community studies it is often of interest to study the effect of species related trait variables on abundances or presence-absences. Specifically, the interest may lay in the interactions between environmental and trait variables. An increasingly popular approach for studying such interactions is to use the so-called fourth-corner model, which explicitly posits a regression model where the mean response of each species is a function of interactions between covariate and trait predictors (among other terms). On the other hand, many of the fourth-corner models currently applied in the literature are too simplistic to properly account for variation in environmental and trait resp…
Subject-specific odds ratios in binomial GLMMs with continuous response
2007
In a regression context, the dichotomization of a continuous outcome variable is often motivated by the need to express results in terms of the odds ratio, as a measure of association between the response and one or more risk factors. Starting from the recent work of Moser and Coombs (Odds ratios for a continuous outcome variable without dichotomizing, Statistics in Medicine, 2004, 23, 1843-1860), in this article we explore in a mixed model framework the possibility of obtaining odds ratio estimates from a regression linear model without the need of dichotomizing the response variable. It is shown that the odds ratio estimators derived from a linear mixed model outperform those from a binom…
Modeling Posidonia oceanica growth data: from linear to generalized linear mixed models
2010
The statistical analysis of annual growth of Posidonia oceanica is traditionally carried out through Gaussian linear models applied to untransformed, or log-transformed, data. In this paper, we claim that there are good reasons for re-considering this established practice, since real data on annual growth often violate the assumptions of Gaussian linear models, and show that the class of Generalized Linear Models (GLMs) represents a useful alternative for handling such violations. By analyzing Sicily PosiData-1, a real dataset on P. oceanica growth data gathered in the period 2000–2002 along the coasts of Sicily, we find that in the majority of cases Normality is rejected and the effect of …
A differential-geometric approach to generalized linear models with grouped predictors
2016
We propose an extension of the differential-geometric least angle regression method to perform sparse group inference in a generalized linear model. An efficient algorithm is proposed to compute the solution curve. The proposed group differential-geometric least angle regression method has important properties that distinguish it from the group lasso. First, its solution curve is based on the invariance properties of a generalized linear model. Second, it adds groups of variables based on a group equiangularity condition, which is shown to be related to score statistics. An adaptive version, which includes weights based on the Kullback-Leibler divergence, improves its variable selection fea…
Bayesian assessment of times to diagnosis in breast cancer screening
2008
Breast cancer is one of the diseases with the most profound impact on health in developed countries and mammography is the most popular method for detecting breast cancer at a very early stage. This paper focuses on the waiting period from a positive mammogram until a confirmatory diagnosis is carried out in hospital. Generalized linear mixed models are used to perform the statistical analysis, always within the Bayesian reasoning. Markov chain Monte Carlo algorithms are applied for estimation by simulating the posterior distribution of the parameters and hyperparameters of the model through the free software WinBUGS.
A gradient-based deletion diagnostic measure for generalized linear mixed models
2016
ABSTRACTA gradient-statistic-based diagnostic measure is developed in the context of the generalized linear mixed models. Its performance is assessed by some real examples and simulation studies, in terms of ability in detecting influential data structures and of concordance with the most used influence measures.
Model selection in linear mixed-effect models
2019
Linear mixed-effects models are a class of models widely used for analyzing different types of data: longitudinal, clustered and panel data. Many fields, in which a statistical methodology is required, involve the employment of linear mixed models, such as biology, chemistry, medicine, finance and so forth. One of the most important processes, in a statistical analysis, is given by model selection. Hence, since there are a large number of linear mixed model selection procedures available in the literature, a pressing issue is how to identify the best approach to adopt in a specific case. We outline mainly all approaches focusing on the part of the model subject to selection (fixed and/or ra…
Segmented mixed models with random changepoints: a maximum likelihood approach with application to treatment for depression study
2014
We present a simple and effective iterative procedure to estimate segmented mixed models in a likelihood based framework. Random effects and covariates are allowed for each model parameter, including the changepoint. The method is practical and avoids the computational burdens related to estimation of nonlinear mixed effects models. A conventional linear mixed model with proper covariates that account for the changepoints is the key to our estimating algorithm. We illustrate the method via simulations and using data from a randomized clinical trial focused on change in depressive symptoms over time which characteristically show two separate phases of change.
Adaptive designs with correlated test statistics
2009
In clinical trials, the collected observations such as clustered data or repeated measurements are often correlated. As a consequence, test statistics in a multistage design are correlated. Adaptive designs were originally developed for independent test statistics. We present a general framework for two-stage adaptive designs with correlated test statistics. We show that the significance level for the Bauer-Köhne design is inflated for positively correlated test statistics from a bivariate normal distribution. The decision boundary for the second stage can be modified so that type one error is controlled. This general concept is expandable to other adaptive designs. In order to use these de…
Frequentist and Bayesian approaches for a joint model for prostate cancer risk and longitudinal prostate-specific antigen data
2015
The paper describes the use of frequentist and Bayesian shared-parameter joint models of longitudinal measurements of prostate-specific antigen (PSA) and the risk of prostate cancer (PCa). The motivating dataset corresponds to the screening arm of the Spanish branch of the European Randomized Screening for Prostate Cancer study. The results show that PSA is highly associated with the risk of being diagnosed with PCa and that there is an age-varying effect of PSA on PCa risk. Both the frequentist and Bayesian paradigms produced very close parameter estimates and subsequent 95% confidence and credibility intervals. Dynamic estimations of disease-free probabilities obtained using Bayesian infe…