Search results for "Linker"

Immunoreagents and competitive assays to fludioxonil

2014

Fludioxonil is a new-generation fungicide widely used for postharvest fruit protection. The aim of this study was to produce hitherto unreported immunoreagents for Fludioxonil analysis by immunoassay. Derivatives of this agrochemical were synthesized with different linker tethering sites. Those functionalized haptens were activated, and the purified active esters were efficiently conjugated to different carrier proteins for immunogen and assay antigen preparation. Antibodies to Fludioxonil were raised in rabbits, and their selectivity and affinity were characterized, revealing the significance of the linker. Those antibodies were evaluated using homologous and heterologous conjugates by dir…

Synthesis and Characterization of Base Labile Poly(N-isopropylacrylamide) Networks Utilizing a Reactive Cross-Linker

2008

Tetrazīna fragmentu saturošu linkeru sintēze proteīnu modificēšanai

2022

Maģistra darbā ir veikta jaunu, alifātisku un PEG fragmentus saturošu, tetrazīna linkeru sintēze proteīnu biokonjugācijai. Darba ietvaros iegūti un izolēti 3 linkeri, kas paredzēti neselektīvai Lys aminoskābju atlikumu modificēšanai, un arī iegūti vēl 3 linkeri, kas paredzēti reģiospecifiskai proteīna N-gala modificēšanai. Darba ietvaros arī izolēts viens linkeris, kas paredzēts His modificēšanai. Visi sintezētie linkeri tika testēti modificējot Borrelia Burgdorferi MlpC lipoproteīnu, kā arī veikta paraugu MALDI-TOF MS analīze, kurā no septiņiem linkeriem, seši ir uzrādījuši konjugāta veidošanos ar MlpC.

Characterization of New Organic Nitrate Hybrid Drugs Covalently Bound to Valsartan and Cilostazol

2012

Background and Purpose: Organic nitrates represent a group of nitrovasodilators that are clinically used for the treatment of ischemic heart disease. With the present studies we synthesized and characterized new organic nitrate hybrid molecules. Compounds CLC-1265 (valsartan mononitrate) and CLC-1280 (valsartan dinitrate) are derivatives of the angiotensin receptor blocker valsartan, with CLC-1265 containing a single organic nitrate linker and CLC-1280 also containing a second, different linker. Compounds CLC-2000 (cilostazol mononitrate) and CLC-2100 (cilostazol dinitrate) are nitrate derivatives of the phosphodiesterase III inhibitor cilostazol. All compounds are designed as hybrid molecu…

Positive effect of the fluorine moiety on the oxygen storage capacity of UiO-66 metal–organic frameworks

2016

Two series of fluorine-containing UiO-66 have been synthesized, replacing the 1,4-benzodicarboxylic acid linker with increasing amounts of 2-fluoro-1,4-benzodicarboxylic acid or 2-trifluoromethyl-1,4-benzodicarboxylic acid. The capacity to store oxygen and nitrogen within these MOFs has been tested, which revealed a positive correlation between the fluorine content and the oxygen storage performances.

Effect of modulator connectivity on promoting defectivity in titanium–organic frameworks

2020

The recognition of defect chemistry as a true synthetic tool for targeted creation of defects and controllable performance remains limited by the pool of frameworks explored. The value of defect engineering in controlling the properties of defective frameworks has been beautifully exemplified and largely demonstrated with UiO-type materials based on Zr(iv) nodes. However, titanium–organic frameworks remain largely unexplored in this context arguably due to the complex chemistry in solution of Ti(iv) and the difficulties in growing crystalline solids. We report a systematic study on the ability of mono- and dicarboxylic modulators (benzoic and isophthalic acid) to promote defect creation in …

Double-stranded RNA polyinosinic-polycytidylic acid immobilized onto gamma-Fe2O3 nanoparticles by using a multifunctional polymeric linker.

2007

Influence of a Crosslinker Containing an Azo Group on the Actuation Properties of a Photoactuating LCE System

2016

Photoactuating liquid crystalline elastomers (LCE) are promising candidates for an application as artificial muscles in microdevices. In this work, we demonstrate that by optimizing (1) the illumination conditions and (2) the mixture of azo monomer and azo crosslinker, thick films of an all-azo LCE can be prepared, which show a strong length change without bending during photoactuation. This becomes possible by working with white light (about 440 nm), whose absorption is low, leading to a large penetration depth. By adding an azo crosslinker to a previously prepared system, several improvements of the actuation properties—like a stronger photoactuation at lower operational temperatures—coul…

Synthesis of phenothiazine-based di-anchoring dyes containing fluorene linker and their photovoltaic performance

2015

Abstract A new di-anchoring organic dye based on phenothiazine featuring A-D-π-D-A (acceptor-donor-π-linker-donor-acceptor) configuration with fluorene as the π linker was designed and successfully synthesized. Compared to the corresponding mono-anchoring D-A congener, this new dye exhibited a broader and stronger absorption in the light wavelength ranging from 400 nm to 600 nm and thus showed a more efficient photovoltaic performance for dye-sensitized solar cells (DSSCs). The overall power conversion efficiency (η) of this new dye in a sensitized solar cell amounted to 5.70%, which is 17% higher than that of the equivalent based counterpart (4.87%). On the other hand, the introduction of …

Synthesis and analysis of activity of a potential anti-melanoma prodrug with a hydrazine linker

2013

A potential anti-melanoma prodrug containing a phenolic activator, a hydrazine linker, and a nitrogen mustard effector - (N-{4-[bis-(2-chloroethyl)amino]benzoyl}-N'-(4-hydroxybenzyl)hydrazine) has been synthesized in seven steps. Spectrophotometric measurements of its oxidation by tyrosinase showed a rapid increase of absorbance at 337 nm. HPLC analysis demonstrated that two major products were formed. However, during the reaction one of the products was converted into the other. The stable product with a maximum of absorption at 337 nm was isolated and identified as 5,6-dihydroxy-1H-indazol-1-yl 4-[bis-(2-chloroethyl)amino]benzoate. It was formed by a cyclization of the enzymatically gener…