Search results for "Logo"
showing 10 items of 1128 documents
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.
2010
Despite the presence of mutations in APC or beta-catenin, which are believed to activate the Wnt signalling cascade constitutively, most colorectal cancers show cellular heterogeneity when beta-catenin localization is analysed, indicating a more complex regulation of Wnt signalling. We explored this heterogeneity with a Wnt reporter construct and observed that high Wnt activity functionally designates the colon cancer stem cell (CSC) population. In adenocarcinomas, high activity of the Wnt pathway is observed preferentially in tumour cells located close to stromal myofibroblasts, indicating that Wnt activity and cancer stemness may be regulated by extrinsic cues. In agreement with this noti…
Bibliometric analysis of the Annual Review of Legal Psychology journal between 1991-2019
2021
[EN]: The present study carries out a bibliometric analysis of Annual Review of Legal Psychology from 1991 to 2019. Data were collected from a database that allows for the analysis of authors, institutions, countries, gender, topics, and impact. The results enable us to observe gender discrepancies among authors, with a a higher frequency of women (50.2%), and the number of signatures (53.7% men). Over the years there is an increase in the number of authors and signatures, of co-authorship, a higher presence of international signatures, representing 23.5% between 2011 and 2019. Three collaboration groups were identified, two from Spain and one from Colombia. Categories of Legal and Forensic…
Synthesis of 131I-labeled glucose-conjugated inhibitors of O6-methylguanine-DNA methyltransferase (MGMT) and comparison with nonconjugated inhibitors…
2006
O 6 -Substituted guanine derivatives are powerful agents used for tumor cell sensitization by inhibition of the DNA repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT). To provide targeted accumulation of MGMT inhibitors in tumor tissue as well as tools for in vivo imaging, we synthesized iodinated C 8 -alkyl-linked glucose conjugates of 2-amino-6-(5-iodothenyl)-9H-purine (O 6 -(5-iodothenyl) guanine, ITG) and 2-amino-6-(3-iodobenzyloxy)-9H-purine (O 6 -(5-iodobenzyl) guanine, IBG). These compounds have MGMT inhibitor constants (IC 5 0 values) of 0.8 and 0.45 μM for ITGG and IBGG, respectively, as determined in HeLa S3 cells after 2-h incubation with inhibitor. To substantiate tha…
In vivo biodistribution and lifetime analysis of cy5.5-conjugated rituximab in mice bearing lymphoid tumor xenograft using time-domain near-infrared …
2008
Rituximab is a chimeric monoclonal antibody directed against human CD20 antigen, which is expressed on B-cell lymphocytes and on the majority of B-cell lymphoid malignancies. Herein we report the conjugate of rituximab with the near-infrared (NIR) fluorophore Cy5.5 (RI-Cy5.5) as a tool for in vitro, in vivo, and ex vivo NIR time-domain (TD) optical imaging. In vitro, RI-Cy5.5 retained biologic activity and led to elevated cell-associated fluorescence on tumor cells. In vivo, TD optical imaging analysis of RI-Cy5.5 injected into lymphoma-bearing mice revealed a slow tumor uptake and a specific long-lasting persistence of the probe within the tumor. Biodistribution studies after intraperiton…
Molecular Cloning, Heterologous Expression, and Characterization of Ornithine Decarboxylase from Oenococcus oeni
2011
International audience; Ornithine decarboxylase (ODC) is responsible for the production of putrescine, the major biogenic amine found in wine. Oenococcus oeni is the most important lactic acid bacterium in the winemaking process and is involved in malolactic fermentation. We report here the characterization of ODC from an O. oeni strain isolated from wine. Screening of 263 strains isolated from wine and cider from all over the world revealed that the presence of the odc gene appears to be strain specific in O. oeni. After cloning, heterologous expression in Escherichia coli, and characterization, the enzyme was found to have a molecular mass of 85 kDa and a pI of 6.2 and revealed maximal ac…
An overview of doping in sports
2019
The history of doping field can be outlined in three major stages: (1) early stage in which drug abuse took place during sports performance and competition and gas chromatography was used for its detection; (2) approximately in the 1970s when androgenic anabolic steroids were introduced; (3) In the recent era when the fields of biochemistry, physiology, toxicology, genomics, genetics, immunology, and molecular biology were integrated and applied routinely. Advanced omics technology and gene doping age may be applied in near future. This review will discuss commonly abused materials, both their adverse and harmful effects, and the alleged benefits in conjunction with the current standards in…
¿Reproduciendo la lógica mediática?. Un estudio empírico sobre el impacto del debate electoral español en nuevos y viejos medios
2013
Producción Científica
Exploring the work in the blogosphere: the paradox of collaborative learning
2016
Amb l’objectiu de solucionar diversos problemes que sorgiren en la posada en practica d’una experiencia d’innovacio basada en la creacio d’una blogosfera, es porta a terme una investigacio educativa i qualitativa a partir de la col·laboracio docent i de les opinions de l’alumnat. A mes dels aspectes positius, es detectaren dificultats amb la gestio del treball en equipo i de familiaritzacio amb la ferramenta a les que els propis estudiants proposaren diverses solucions. Abordar aquesta circumstancia de forma col·laborativa i donant veu a l’alumnat ha permes que l’experiencia concloguera exitosament, resultant ser una bona practica educativa.
La blogosfera política española en las Elecciones Generales 2011. Una comparación entre blogs de candidatos, periodistas y ciudadanos
2015
En: Doxa Comunicación : revista interdisciplinar de estudios de comunicación y ciencias sociales. ISSN 1696-019X n. XXI, 2015, pp 78-112 El presente estudio propone un análisis de la blogosfera política española durante la campaña electoral previa a las Elecciones Generales del 20 de noviembre de 2011, con el fin de identificar los principales temas de discusión que centraron el debate en tres tipos de bitácoras: seis blogs de candidatos políticos de las principales formaciones políticas españolas, cuatro a cargo de periodistas destacados de la esfera pública central y cuatro de ciudadanos anónimos. Se plantea un análisis de contenido fundamentado en 57 categorías temáticas para establecer …
Semiotics, blogs and gastromania
2021
The current culinary megatrend owes much to Internet socialization practices. Discussions online began very early (the boards of Chowhound, for example, have already been operating since 1997), which says a lot about how much the “great conversation” of online communities is linked to gastronomic discourse. This paper propose a semiotic assessment of such a connection.