Search results for "Loi"
showing 10 items of 4617 documents
Genomic structure and functional characterization of the human ADAM10 promoter
2005
The ADAM10 gene encodes a membrane-bound disintegrin-metalloproteinase, which, after overexpression in an Alzheimer disease (AD) mouse model, prevents amyloid pathology and improves long-term potentiation and memory. Because enhancing ADAM10 expression appears to be a reasonable approach for treatment of AD, we functionally analyzed the ADAM10 gene. Both human and mouse ADAM10 genes comprise approximately 160 kbp, are composed of 16 exons, and are evolutionarily highly conserved within 500 bp upstream of either translation initiation site. By using luciferase reporter assays, we demonstrate that nucleotides -2179 to -1 upstream of the human ADAM10 translation initiation site represent a fun…
Tunable Superstructures of Dendronized Graphene Nanoribbons in Liquid Phase
2019
In this Communication, we report the first synthesis of structurally well-defined graphene nanoribbons (GNRs) functionalized with dendritic polymers. The resultant GNRs possess grafting ratios of 0.59-0.68 for the dendrons of different generations. Remarkably, the precise 3D branched conformation of the grafted dendrons affords the GNRs unprecedented 1D supramolecular self-assembly behavior in tetrahydrofuran (THF), yielding nanowires, helices and nanofibers depending on the dimension of the dendrons. The GNR superstructures in THF exhibit near-infrared absorption with maxima between 650 and 700 nm, yielding an optical bandgap of 1.2-1.3 eV. Ultrafast photoconductivity analyses unveil that …
Marine Indole Alkaloids.
2015
Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. The newly isolated indole alkaloids of marine origin since the last comprehensive review in 2003 are reported, and biological aspects will be discussed.
Nanoparticles in the Biological Context: Surface Morphology and Protein Corona Formation
2020
Small 16(39), 2002162 (2020). doi:10.1002/smll.202002162
Allopolyploidisation in a geological collision zone: on the origin of the tetraploid Anthemis cupaniana Nyman (Compositae, Anthemideae) in Sicily
2022
AbstractThe genus Anthemis has a circum-Mediterranean distribution and comprises c. 175 annual, biennial, and perennial species with polyploid species and species complexes found in its section A. sect. Hiorthia. In Sicily, the genus is represented by 13 species, one of these being the tetraploid A. cupaniana, which is endemic to the island and is distributed throughout the limestone mountains at elevations between 500 and 1800 m a.s.l. Discordant positions in phylogenetic trees based on two plastid regions (psbA-trnH and trnC-petN) and on one nuclear marker (nrDNA ITS1 + 5.8S + ITS2) reveal that the species is of allopolyploid origin, with the maternal parent from the species group around …
"Oi Herra, säästä meidät muhamettilaisten raivolta" : islaminuskoisten varhaiset (632-750 jaa.) valloitukset 1900-luvun lopun ja 2000-luvun alun läns…
2015
Tutkielman tarkoituksena on tarkastella angloamerikkalaisen historiankirjoituksen antamaa kuvaa islamin varhaisista valloituksista. Tutkimuksen kohteena eivät suoranaisesti ole itse valloitukset, vaan nykyaikaisten länsimaisten historiankirjoittajien niistä luoma kuva. Tutkielmassa vertaillaan eri historioitsijoiden näkemyksiä avainteemoista (lähdemateriaalin käsittely, valloituksiin johtaneet ja ne mahdollistaneet syyt) sekä pohditaan, miten ja miksi ne eroavat toisistaan. Tutkielma on historiografinen kvalitatiivinen kirjallisuustutkimus, jossa käytetään kontekstuaalista tutkimusmenetelmää orientalistisessa viitekehyksessä. Tutkielman alkuperäislähteinä käytetään 1970-luvulta lähtien ilme…
Child Pornography and other Sexual Offenses: A Criminological study
2019
Esta tesis tiene como objetivo el análisis criminológico de la delincuencia sexual, con un especial énfasis en los delitos relativos a la pornografía infantil. Para ello, se propone un estudio en profundidad que permita acercarnos, desde un punto de vista científico e interdisciplinar −alejado de la histeria social y los pánicos morales que han calado en el imaginario colectivo de nuestra sociedad−, a un fenómeno delictivo que sigue suscitando grandes preguntas entre la comunidad científica. En primer lugar, nos centraremos en el estudio global de los delincuentes sexuales. En concreto, en el Estudio 1 se analizaron las diferencias y semejanzas entre delincuentes sexuales y no sexuales, con…
Central nervous system involvement at first relapse in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycl…
2009
Background The prevalence of and risk factors for central nervous system recurrence in patients with acute promyelocytic leukemia are not well established and remain a controversial matter. Design and Methods Between 1996 and 2005, 739 patients with newly diagnosed acute promyelocytic leukemia enrolled in two consecutive trials (PETHEMA LPA96 and LPA99) received induction therapy-with all-trans retinoic acid and idarubicin. Consolidation therapy comprised three courses of anthracycline monochemotherapy (LPA96), with all-trans retinoic acid and reinforced doses of idarubicin in patients with an intermediate or high risk of relapse (LPA99). Central nervous system prophylaxis was not given. Re…
Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell
2019
Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain several chemical classes of compounds whose heterogeneity of active moieties can help prevent the development of drug resistance. In the present paper, we analyzed, by gas chromatography-mass spectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensis obtained by hydrodistillation and compared the chemical composition of its essential oil with that of Cyphostemma juttae.…
Strategies to gain novel Alzheimer’s disease diagnostics and therapeutics using modulators of ABCA transporters
2021
Adenosine-triphosphate-(ATP)-binding cassette (ABC) transport proteins are ubiquitously present membrane-bound efflux pumps that distribute endo- and xenobiotics across intra- and intercellular barriers. Discovered over 40 years ago, ABC transporters have been identified as key players in various human diseases, such as multidrug-resistant cancer and atherosclerosis, but also neurodegenerative diseases, such as Alzheimer���s disease (AD). Most prominent and well-studied are ABCB1, ABCC1, and ABCG2, not only due to their contribution to the multidrug resistance (MDR) phenotype in cancer, but also due to their contribution to AD. However, our understanding of other ABC transporters is limited…