Search results for "Longevity"

showing 10 items of 378 documents

Association between longevity and cytokine gene polymorphisms. A study in Sardinian centenarians

2004

Background and aims: Human longevity seems to be directly correlated with optimal functioning of the immune system, suggesting that some genetic determinants of longevity reside in those polymorphisms for the immune system genes which regulate immuneinflammatory responses, in particular cytokine gene polymorphisms. The frequency of − 174C single nucleotide polymorphism (SNP) in the promoter region of the interleukin(IL)-6 gene is increased in Italian male centenarians. Moreover, the frequency of − 1082G SNP at the 5′ flanking region of the IL-10 gene coding sequence is increased among male centenarians, and that of +874A SNP at the interferon (IFN)- γ gene was found more frequently in femal…

MaleAgingmedia_common.quotation_subjectLongevityPopulationSingle-nucleotide polymorphismEnvironmentBiologyPolymorphism Single NucleotideInterferon-gammaPolymorphism (computer science)HumansSNPAlleleeducationGeneAgedmedia_commonAged 80 and overeducation.field_of_studyInterleukin-6LongevityMiddle AgedInterleukin-10ItalyImmunologyCytokinesFemaleGene poolGeriatrics and Gerontology
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HLA and KIR Frequencies in Sicilian Centenarians

2010

Several studies suggest that human longevity appears to be linked inextricably with optimal functioning of the immune system, suggesting that specific genetic determinants may reside in loci that regulate the immune response, as human leukocyte antigen (HLA) and killer cell immunoglobulin-like receptor (KIR) genes. It has been suggested that longevity is associated with positive selection of alleles (i.e., HLA-DR11) or haplotypes (i.e., HLA-B8,DR3) that confer resistance to infectious disease(s). On the other hand, the cytolytic activity of natural killer (NK) cells is controlled by activating and inhibitory cell-surface receptors, including KIR. The genetic diversity of the KIR loci with r…

MaleAgingmedia_common.quotation_subjectLongevityPopulationchemical and pharmacologic phenomenaHuman leukocyte antigenBiologyHLA-B8 AntigenImmune systemGene FrequencyReceptors KIRHumansSettore MED/05 - Patologia ClinicaAlleleReceptoreducationSicilyGeneAllelesmedia_commonAged 80 and overGeneticsSettore MED/04 - Patologia Generaleeducation.field_of_studyHaplotypeLongevityHLA-DR AntigensHLA KIR successful ageingCase-Control StudiesImmunologyFemaleGeriatrics and GerontologyHLA-DRB1 Chains
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Genetic signatures of centenarians: Implications for achieving successful aging

2019

The extraordinary rise in the old population in the Western world underscores the importance of studies on aging and longevity to decrease the medical, economic and social problems associated with the increased number of non-autonomous individuals affected by invalidating pathologies. Centenarians have reached the extreme limits of the human life span. They are the best example of extreme longevity, representing selected individuals in which the appearance of major age-related diseases has been consistently delayed or avoided. There is growing evidence that the genetic component of longevity becomes higher with survival at the age of over 90 years. For centenaries, it reaches up to 33% for…

MaleAgingmedia_common.quotation_subjectSuccessful agingPopulationLongevityContext (language use)Biologycentenarian03 medical and health sciences0302 clinical medicineDrug DiscoveryCardiovascular diseases; Centenarians; Genetics; Immune-inflammatory responses; Longevity; Successful agingCentenariansGeneticsHumansAlleleeducationAlleles030304 developmental biologymedia_commonImmune-inflammatory responsesAged 80 and overPharmacology0303 health scienceseducation.field_of_studySuccessful agingLongevityCardiovascular diseasePhenotypeCardiovascular diseasesimmune-inflammatory responseTraitLife expectancyFemalesuccessful aging.Centenariangenetic030217 neurology & neurosurgeryDemography
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Women Live Longer than Men: Understanding Molecular Mechanisms Offers Opportunities to Intervene by Using Estrogenic Compounds

2010

Abstract Women live longer than men. Moreover, females live longer than males in some, but not all, experimental animals. The differences in longevity between genders are related to free radical production. Indeed, females produce less radicals only in animal species in which they live longer than males. This is because estrogens upregulate antioxidant longevity-related genes. These considerations have led us to postulate an extended concept of antioxidant in biology: an antioxidant is any nutritional, physiological, or pharmacological manipulation that increases the expression and activity of antioxidant genes or proteins. Phytoestrogens or other selective estrogen receptor modulators lowe…

MaleAgingmedicine.medical_specialtyAntioxidantFree RadicalsPhysiologymedia_common.quotation_subjectmedicine.medical_treatmentLongevityClinical BiochemistryPhytoestrogensEstrogenic CompoundsBiologyBiochemistryAntioxidantschemistry.chemical_compoundLife ExpectancySex FactorsInternal medicinemedicineAnimalsHumansAnimal speciesMolecular BiologyGeneral Environmental Sciencemedia_commonLife spanLongevityEstrogensCell BiologyOxidative StressEndocrinologychemistrySelective estrogen receptor modulatorGeneral Earth and Planetary SciencesFemalePhytoestrogensAntioxidants & Redox Signaling
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Muscle strength and mobility as predictors of survival in 75-84-year-old people.

1995

The purpose of the study was to examine the association of physical capacity, as determined on the basis of self-report and physical measurements, with survival in three groups of elderly people aged 75, 80 and 75-84 years. The main aspects of physical capacity were mobility, walking speed, hand grip strength and knee extension strength. Although 1142 persons participated in mobility interview, of whom 466 also took part in the walking speed test, and 463 in the strength tests. The follow-up periods ranged from 48 to 58 months. Risk of death was significantly related to difficulties in indoor mobility among the 75-84-year-olds (odds ratio = 1.99, 95% confidence interval = 1.27-3.13) and 75-…

MaleAgingmedicine.medical_specialtyLongevityGrip strengthPredictive Value of TestsReference ValuesIsometric ContractionMedicineHumansGeriatric AssessmentAgedAged 80 and overbusiness.industryGeneral MedicineOdds ratioConfidence intervalTest (assessment)Preferred walking speedPhysical FitnessPredictive value of testsMuscle strengthPhysical therapyExercise TestFemaleRisk of deathGeriatrics and Gerontologybusinesshuman activitiesLocomotionFollow-Up StudiesAge and ageing
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Conserved role of Ras-GEFs in promoting aging: from yeast to mice

2011

RasGRF1 is a Ras-guanine nucleotide exchange factor implicated in a variety of physiological processes including learning and memory and glucose homeostasis. To determine the role of RASGRF1 in aging, lifespan and metabolic parameters were analyzed in aged RasGrf1(-/-) mice. We observed that mice deficient for RasGrf1(-/-) display an increase in average and most importantly, in maximal lifespan (20% higher than controls). This was not due to the role of Ras in cancer because tumor-free survival was also enhanced in these animals. Aged RasGrf1(-/-) displayed better motor coordination than control mice. Protection against oxidative stress was similarly preserved in old RasGrf1(-/-). IGF-I lev…

MaleAgingpositron emission tomographyProtein familyCellular differentiationLongevityCellSaccharomyces cerevisiaeSaccharomyces cerevisiaeMiceSirtuin 1RNA Ribosomal 16SmedicineAnimalsInsulin-Like Growth Factor IGEFCaloric RestrictionMice KnockoutBase Sequenceaging stress resistance yeast lifespanbiologyras-GRF1SUPERFAMILYCell Biologybiology.organism_classificationMolecular biologyYeastLiver GlycogenCell biologyMice Inbred C57BLOxidative StressGlucosemedicine.anatomical_structureRanCommentaryMetabolomeIGF-1Femaleras Guanine Nucleotide Exchange FactorsRabmetabolismPsychomotor PerformanceResearch PaperRasAging
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SARS CoV2 infection _The longevity study perspectives

2021

Graphical abstract

MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Polymorphisms of pro-inflammatory genes and prostate cancer risk: a pharmacogenomic approach.

2009

In this paper, we consider the role of the genetics of inflammation in the pathophysiology of prostate cancer (PCa). This paper is not an extensive review of the literature, rather it is an expert opinion based on data from authors' laboratories on age-related diseases and inflammation. The aim is the detection of a risk profile that potentially allows both the early identification of individuals at risk for disease and the possible discovery of potential targets for medication. In fact, a major goal of clinical research is to improve early detection of age-related diseases, cancer included, by developing tools to move diagnosis backward in disease temporal course, i.e., before the clinical…

MaleCancer ResearchPathologymedicine.medical_specialtyAgingpharmacogenomicmedicine.medical_treatmentImmunologyGenomicsDiseaseBioinformaticsProstate cancerlongevitySettore MED/05 - Patologia ClinicaImmunology and AllergyMedicineHumansGenetic Predisposition to DiseaseSettore MED/04 - Patologia GeneraleInflammationPolymorphism Geneticbusiness.industryCancerProstatic NeoplasmsImmunotherapyprostate cancermedicine.diseaseClinical researchOncologyageingPharmacogeneticsPharmacogenomicsgeneticInflammation MediatorsbusinessPharmacogeneticsCancer immunology, immunotherapy : CII
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Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity

2008

A key component of atherosclerosis is inflammation. So, genes encoding inflammatory or antiinflammatory molecules are good candidates for the risk of cardiovascular diseases (CVD), as acute myocardial infarction (AMI). In this study we demonstrated that genetic variations in CCR5 gene affect atherosclerosis and risk of AMI, hence consenting the attainment of longevity.

MaleChemokineReceptors CCR5media_common.quotation_subjectLongevityMyocardial InfarctionInfarctionInflammationRisk FactorsmedicineHumansGenetic Predisposition to DiseaseMyocardial infarctionReceptorSicilyAllelesAgedmedia_commonAged 80 and overInflammationSettore MED/04 - Patologia Generalebiologybusiness.industryLongevityHematologyAtherosclerosismedicine.diseasePathophysiologyCardiovascular DiseasesImmunologybiology.proteinFemaleinfarction longevity CCR5medicine.symptomCC chemokine receptorsbusinessHaematologica
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Elite athletes live longer than the general population: a meta-analysis

2014

OBJECTIVE: To perform a meta-analysis of cohort studies aimed at providing an accurate overview of mortality in elite athletes. PATIENTS AND METHODS: We reviewed English-language scientific articles available in Medline and Web of Science databases following the recommendations of the Meta-analyses Of Observational Studies in Epidemiology group. We searched for publications on longevity and professional or elite athletes (with no restriction on the starting date and up to March 31, 2014). RESULTS: Ten studies, including data from a total of 42,807 athletes (707 women), met all inclusion criteria. The all-cause pooled standard mortality ratio (SMR) was 0.67 (95% CI, 0.55-0.81; P<.001) with n…

MaleCienciamedicine.medical_specialtyPopulationLongevityDeportistasLower riskRisk FactorsNeoplasmsEpidemiologymedicineHumansMortalityeducationCiencias médicaseducation.field_of_studybiologyAthletesbusiness.industryGeneral MedicinePublication biasbiology.organism_classificationEjercicioStandardized mortality ratioAthletesCardiovascular DiseasesMeta-analysisFemalebusinessDemographyCohort study
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