Search results for "Lua"

showing 10 items of 3286 documents

Predictive Score Card in Lumbar Disc Herniation: Is It Reflective of Patient Surgical Success after Discectomy?

2016

Does the Finneson–Cooper score reflect the true value of predicting surgical success before discectomy? The aim of this study was to identify reliable predictors for surgical success two year after surgery for patients with LDH. Prospective analysis of 154 patients with LDH who underwent single-level lumbar discectomy was performed. Pre- and post-surgical success was assessed by the Oswestry Disability Index (ODI) over a 2-year period. The Finneson-Cooper score also was used for evaluation of the clinical results. Using the ODI, surgical success was defined as a 30% (or more) improvement on the ODI score from the baseline. The ODI was considered the gold standard in this study. Finally, the…

MaleMedical Doctorsgenetic structuresPsychometricsHealth Care Providersmedicine.medical_treatmentSocial Scienceslcsh:MedicinePathology and Laboratory MedicineSeverity of Illness IndexDiagnostic RadiologyDisability Evaluation0302 clinical medicineSurveys and QuestionnairesOutcome Assessment Health CareMedicine and Health SciencesPsychologyProspective Studies030212 general & internal medicinelcsh:ScienceProspective cohort studyMusculoskeletal SystemAged 80 and overLumbar VertebraeMultidisciplinaryRadiology and ImagingMiddle AgedResearch AssessmentPrognosisMagnetic Resonance ImagingOswestry Disability IndexProfessionsmedicine.anatomical_structurePreoperative PeriodFemaleAnatomyIntervertebral Disc DisplacementDiskectomyResearch ArticleAdultmedicine.medical_specialtyPsychometricsSystematic ReviewsImaging TechniquesLower Back PainPainSurgical and Invasive Medical ProceduresLumbar vertebraeResearch and Analysis Methods03 medical and health sciencesSigns and SymptomsDiagnostic MedicinePhysiciansDiscectomySeverity of illnessmedicineHumansAgedSurgeonsSurgical repairbusiness.industrylcsh:RGold standardReproducibility of ResultsBiology and Life SciencesSpineSurgeryHealth CareSurgical RepairPeople and PlacesPhysical therapyPopulation Groupingslcsh:Qbusiness030217 neurology & neurosurgeryPLOS ONE
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Prediction of cardiovascular disease by the framingham-REGICOR equation in the high-risk PREDIMED cohort: Impact of the mediterranean diet across dif…

2017

Background-The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We assessed the efficacy of the Framingham-REGICOR scale, validated for the Spanish population, to identify future CVD in participants, who were predefined as being at high-risk in the PREvención con DIeta MEDiterránea (PREDIMED) study-a nutrition-intervention primary prevention trial-and the impact of adherence to the Mediterranean diet on CVD across risk categories. Methods and Results-In a post hoc analysis, we assessed the CVD predictive value of baseline estimated risk in 5966 PREDIMED participants (aged 55-74 years, 57% women; 48% with type 2 diabetes mellitus). Major …

MaleMediterranean dietEpidemiologyDisease030204 cardiovascular system & hematologyDiet MediterraneanCohort Studies0302 clinical medicineRisk FactorsMedicine030212 general & internal medicineRisk assessmentOriginal ResearchDiet and NutritionAged 80 and overFramingham Risk ScoreDiabetisDiabetesMiddle AgedPrognosisCardiovascular diseasePrimary PreventionCardiovascular diseasesCardiovascular DiseasesCohortFemaleCardiology and Cardiovascular MedicineFramingham‐REGICOR equationPREDIMEDCardiovascular risk predictionScale (ratio)Risk Assessment03 medical and health sciencesMediterranean dietHumanscardiovascular diseasesAgedProportional Hazards ModelsFramingham-REGICOR equationbusiness.industryMalalties cardiovascularsFeeding BehaviorLifestylePredimedDiabetes Mellitus Type 2SpainAvaluació del riscMediterraneam dietbusinessDemography
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Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study

2020

Background. Body weight dissatisfaction is a hindrance to following a healthy lifestyle and it has been associated with weight concerns. Objectives. The aim of this study was to assess the association between the adherence to the Mediterranean lifestyle (diet and exercise) and the desired body weight loss in an adult Mediterranean population with overweight. Methods. Cross-sectional analysis in 6355 participants (3268 men; 3087 women) with metabolic syndrome and BMI (Body mass index) between 27.0 and 40.0 kg/m2 (55–75 years old) from the PREDIMED-Plus trial. Desired weight loss was the percentage of weight that participants wished to lose. It was categorized into four cut-offs of this perce…

MaleMediterranean dietObesidadejercicio físicoBody Mass Index:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]0302 clinical medicineSurveys and QuestionnairesAntineoplastic Combined Chemotherapy ProtocolsMedicinemediana edadeducation.field_of_studyanciano:Health Care::Health Care Quality Access and Evaluation::Quality of Health Care::Epidemiologic Factors::Age Factors [Medical Subject Headings]dietaprotocolos de quimioterapia antineoplásica combinada3. Good healthOlder adultsmetotrexatoprogramas de reducción de pesoObesitatlcsh:Nutrition. Foods and food supplyPersonas mayores frágilesIdeal weightLifestyles:Check Tags::Male [Medical Subject Headings]lcsh:TX341-641ArticleEstilo de vida03 medical and health sciences:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight [Medical Subject Headings]:Anthropology Education Sociology and Social Phenomena::Human Activities::Exercise [Medical Subject Headings]ifosfamidaHumanscisplatinoIfosfamideeducationExerciseAgedconducta alimentaria:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Metabolic Syndrome X [Medical Subject Headings]:Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology Social::Life Style [Medical Subject Headings]PREDIMED-Plusmedicine.diseaseObesityMethotrexate:Check Tags::Female [Medical Subject Headings]Desired weight lossMetabolic syndromeCisplatinBody mass indexDemographyobesitycumplimiento del pacientehumanos:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings]Ideal Body Weightdesired weight loss:Health Care::Health Care Facilities Manpower and Services::Health Promotion::Weight Reduction Programs [Medical Subject Headings]OverweightDiet MediterraneanMediterranean lifestyle:Health Care::Health Care Facilities Manpower and Services::Health Services::Preventive Health Services::Health Promotion::Healthy People Programs [Medical Subject Headings]Weight loss030212 general & internal medicine:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Health Behavior::Patient Compliance [Medical Subject Headings]Abdominal obesityolder adults:Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings]2. Zero hungerNutrition and Dieteticsmediterranean lifestylesobrepeso:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Diet Therapy::Diet Mediterranean [Medical Subject Headings]Age Factorsideal weightMiddle AgedPeso corporal ideal:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Ideal Body Weight [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings]Weight Reduction ProgramsBody imageFemalemedicine.symptompeso corporal idealEstils de vidadoxorrubicinabody imagePopulationImagen corporal030209 endocrinology & metabolism:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior [Medical Subject Headings]overweightHealthy LifestyleObesity:Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]business.industryíndice de masa corporalFeeding BehaviorOverweightDieta mediterráneaDietDoxorubicinSobrepesoPatient Compliance:Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Perception::Body Image [Medical Subject Headings]businessFood Science
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Screening for distress in routine oncological care-a survey in 520 melanoma patients.

2012

Introduction Despite the increasing incidence of melanoma little is known about patients' emotional distress associated with this disease. Supplemented by the problem list (PL), the distress thermometer (DT) is a recommended screening instrument to measure psychosocial distress in cancer patients. Our objective was to explore the acceptance and the feasibility of the DT and PL as a concise screening tool in an ambulatory setting for routine care and to elucidate determinants of distress in melanoma patients with regard to sociodemographic and clinical variables. Methods Consecutive melanoma outpatients were asked to complete the DT with the PL prior to their scheduled consultation. Demograp…

MaleMelanomasPediatricsSkin NeoplasmsNon-Clinical MedicineEpidemiologyEmotionsProblem listlcsh:MedicineDiseaseSocial and Behavioral SciencesQuality of lifeRisk FactorsSurveys and QuestionnairesOutpatientsMass ScreeningPsychologyYoung adultlcsh:ScienceMelanomaSkin TumorsAged 80 and overMultidisciplinaryIncidence (epidemiology)Malignant MelanomaMiddle AgedDistressClinical PsychologyMental HealthOncologyMedicineFemalePsychosocialResearch ArticleTest EvaluationAdultmedicine.medical_specialtyAdolescentSocial PsychologyPsychological StressMalignant Skin NeoplasmsDermatologyYoung AdultDiagnostic MedicinemedicineHumansPsychiatryMass screeningAgedBehaviorHealth Care Policybusiness.industrylcsh:RCancers and NeoplasmsSurvey MethodsHealth Care SurveysQuality of Lifelcsh:QbusinessStress PsychologicalPLoS ONE
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Short-term cost-effectiveness of psychodynamic therapy and cognitive-behavioral therapy in social anxiety disorder: Results from the SOPHO-NET trial

2015

Abstract Background To investigate the short-term cost-effectiveness of cognitive-behavioral therapy (CBT) and psychodynamic therapy (PDT) compared to waiting list (WL). Methods The analysis was conducted alongside the SOPHO-NET multi-center efficacy trial. Patients were randomly assigned to CBT ( n =209), PDT ( n =207), or WL ( n =79). Resource use was assessed prior and during treatment to determine direct and absenteeism costs. Unadjusted incremental cost-effectiveness ratios (ICERs) were calculated based on remission and response rates. To visualize statistical uncertainty, cost-effectiveness acceptability curves (CEACs) were constructed based on adjusted net-benefit regression. Differe…

MaleMental Health Servicesmedicine.medical_specialtyTime FactorsWaiting ListsCost effectivenessCost-Benefit Analysismedicine.medical_treatmentPsychological interventionGroup psychotherapyIndirect costsWillingness to paymedicineHumansPsychiatryhealth care economics and organizationsCognitive Behavioral TherapyMiddle Aged3. Good healthCognitive behavioral therapyPsychiatry and Mental healthClinical PsychologyTreatment OutcomePhobic DisordersEconomic evaluationAbsenteeismPhysical therapyFemalePsychologyJournal of Affective Disorders
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A model of stepwise isovolaemic blood exchange in anaesthetised, spontaneously breathing rats to evaluate the oxygen transport efficiency of artifici…

2000

Our research pursues the production of hypo-oncotic artificial oxygen carriers, based on artificial covalently cross-linked hyperpolymeric mammalian haemoglobins. To evaluate their in vivo efficiency in oxygen delivery to the tissue we developed a small animal model of stepwise isovolaemic blood exchange in anaesthetised, spontaneously breathing rats. With the aid of a two-way respiratory micro valve for small animals the overall oxygen uptake by the tissue of the animal can be determined. Measurements of oxygen contents in arterial and mixed venous blood and of some further blood parameters together with known oxygen-binding characteristics of artificial and native oxygen carriers, permits…

MaleMicro valveBiomedical Engineeringchemistry.chemical_elementOxygenRats Sprague-DawleyHemoglobinsOxygen ConsumptionIn vivoBlood SubstitutesAnimalsAnesthesiaRespiratory systemCardiac OutputHemodilutionBlood VolumeChemistryPulmonary Gas ExchangeRespirationOxygen transportBiological TransportOxygen uptakeRatsOxygenBiochemistryHematocritEvaluation Studies as TopicPyridoxal PhosphateBlood CirculationBiophysicsBreathingVascular ResistanceHemoglobinPulmonary VentilationBiotechnologyArtificial cells, blood substitutes, and immobilization biotechnology
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SNPs array karyotyping reveals a novel recurrent 20p13 amplification in primary myelofibrosis.

2011

The molecular pathogenesis of primary mielofibrosis (PMF) is still largely unknown. Recently, single-nucleotide polymorphism arrays (SNP-A) allowed for genome-wide profiling of copy-number alterations and acquired uniparental disomy (aUPD) at high-resolution. In this study we analyzed 20 PMF patients using the Genome-Wide Human SNP Array 6.0 in order to identify novel recurrent genomic abnormalities. We observed a complex karyotype in all cases, detecting all the previously reported lesions (del(5q), del(20q), del(13q), +8, aUPD at 9p24 and abnormalities on chromosome 1). In addition, we identified several novel cryptic lesions. In particular, we found a recurrent alteration involving cytob…

MaleMicroarraysMIELOFIBROSISChromosomes Human Pair 20Loss of Heterozygositylcsh:MedicineLoss of heterozygosityCohort StudiesHematologic Cancers and Related DisordersGene duplicationTaq Polymeraselcsh:ScienceOligonucleotide Array Sequence AnalysisMultidisciplinaryMYELOFIBROSIS; SNPKaryotypeGenomicsHematologyUniparental disomyMedicineFemaleImmunohistochemical AnalysisSNP arrayResearch ArticleTest Evaluationmedicine.medical_specialtyDNA Copy Number VariationsImmunologySNPLocus (genetics)Single-nucleotide polymorphismReceptors Cell SurfaceBiologyPolymorphism Single NucleotideDiagnostic MedicinemedicineGeneticsHumansBiologyAgedEvolutionary BiologyMyeloproliferative DisordersPopulation Biologylcsh:RCytogeneticsGene AmplificationComputational BiologyDNAUniparental Disomymedicine.diseaseMolecular biologyMYELOFIBROSISPrimary MyelofibrosisKaryotypingGenetic PolymorphismImmunologic TechniquesClinical Immunologylcsh:QPopulation GeneticsPLoS ONE
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Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae)

2005

The butanolic fraction of dried leaves of Acacia pennata (Mimosaceae) was tested for analgesic and anti-inflammatory activities in animal models. It showed significant protective effects against chemical stimuli (acetic acid and formalin) in the mouse. It also produced a significant increase of the threshold of sensitivity to pressure-induced pain in the rats. The extract revealed an inhibitory effect in carrageenin-induced rat paw oedema in the late phase. The results suggested that a peripheral mechanism is involved in the analgesic, associated to anti-inflammatory effect (NSAIDs-like). Among the class of compounds characterized in this fraction, flavonoids may be mainly responsible for t…

MaleMimosamedicine.drug_classButanolsAnalgesicDrug Evaluation PreclinicalAdministration OralPainAcacia pennataAcaciaPharmacognosyCarrageenanAnti-inflammatoryMiceAcetic acidchemistry.chemical_compoundFormaldehydeDrug DiscoveryPressuremedicineAnimalsEdemaRats WistarTramadol5-HT receptorAcetic AcidFlavonoidsPharmacologyDose-Response Relationship DrugbiologyTraditional medicinePlant ExtractsAnti-Inflammatory Agents Non-SteroidalAnalgesics Non-Narcoticbiology.organism_classificationStimulation ChemicalHindlimbRatsPlant LeavesDisease Models AnimalNociceptionchemistryFemaleJournal of Ethnopharmacology
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Minimal clinically important difference and minimal detectable change of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0…

2020

Objectives: The aim of this study is to estimate a minimal clinically important difference (MCID) and a minimal detectable change (MDC) of the 12-item WHODAS 2.0 amongst patients with chronic musculoskeletal pain. Design: Cross-sectional cohort study. Setting: Outpatient Physical and Rehabilitation Medicine clinic. Subjects: A total of 1988 consecutive patients with musculoskeletal pain. Interventions: A distribution-based approach was employed to estimate a minimal clinically important difference, a minimal detectable change, and a minimal detectable percent change (MDC%). Results: The mean age of the patients was 48 years, and 65% were women. The average intensity of pain was 6,3 (2.0) po…

MaleMusculoskeletal painSchedule2019-20 coronavirus outbreakmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)WHODASPhysical Therapy Sports Therapy and Rehabilitationminimal detectable changetuki- ja liikuntaelimetWorld healthDisability assessmentCohort StudiesDisability EvaluationMusculoskeletal PainHumansMedicineskin and connective tissue diseasesmusculoskeletal painPain Measurementbusiness.industryMinimal clinically important differenceminimal clinically important differenceRehabilitationkipuMiddle AgedCross-Sectional StudiesPhysical therapyFemalesense organsWhodasChronic PainbusinessData Collection toolsClinical Rehabilitation
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Floor and ceiling effects of the World Health Organization Disability Assessment Schedule 2.0 among patients with chronic musculoskeletal pain

2019

The aim of this study was to investigate the floor and ceiling effects of 12-item World Health Organization Disability Assessment Schedule 2.0 (WHODAS). This was a cross-sectional survey study at a university’s physical and rehabilitation medicine outpatient clinic of 1988 patients with chronic musculoskeletal pain. Floor and ceiling effects were calculated as relative frequencies of the lowest or the highest possible scores for each item. The probit plotting method was used to detect the non-normality of distribution of the total score graphically. A significant floor effect of 15–79% was observed in all 12 WHODAS 2.0 items. A substantial floor effect for total score was also detected grap…

MaleMusculoskeletal painSchedulemedicine.medical_specialtyPsychometricsarviointimenetelmätStatistics as TopicPhysical Therapy Sports Therapy and RehabilitationCeiling (cloud)World Health OrganizationWorld healthDisability assessmentDisability EvaluationMusculoskeletal PainSurveys and QuestionnairesHumansMedicineOutpatient clinictoimintarajoitteetmusculoskeletal painWorld Health Organization Disability Assessment Schedule 2.0business.industryRehabilitationReproducibility of Resultsta3141Survey researchMiddle AgedCross-Sectional StudiesPhysical therapykrooninen kipuFemaleChronic PainbusinessInternational Journal of Rehabilitation Research
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