Search results for "Lung"
showing 10 items of 2389 documents
Trichosporon beigelii pneumonia in a neutropenic patient.
1989
A case of pulmonary infection caused by Trichosporon beigelii is reported in an asthmatic patient undergoing steroid treatment who developed fever and lung infiltrates. Arthroconidia and blastoconidia were isolated from repeated sputum, bronchial aspirate and telescopic catheter samples. The infection coincided with neutropenia resulting from pyrazolone treatment. The response to amphotericin B treatment was favourable.
Type-Specific Antibodies to Pneumococcal Capsular Polysaccharide Acquired either Naturally or after Vaccination with Prevenar in Children with Underl…
2006
ABSTRACT The antibody response to capsular polysaccharides of pneumococcal serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F elicited either naturally or after vaccination with Prevenar was investigated in a cohort of children ( n = 163) with underlying chronic or recurrent lung diseases at risk of developing pneumococcal pneumonia and ultimately invasive disease. Serum concentrations of serotype-specific antibodies, as measured by enzyme-linked immunosorbent assay, in unvaccinated children ( n = 88) were higher in nasopharyngeal carriers ( n = 10) than in noncarriers ( n = 78) both at baseline and during follow-up. However, the antibody levels depended on the serotype and age of the children. Dur…
Time course of mycobacterial infection of dendritic cells in the lungs of intranasally infected mice
2004
Summary Setting : Dendritic cells (DC) could regulate between the protective and pathogenic immune responses following tuberculous infection. In this paper we investigated if their early infection in the lungs represents a plausible alternative to cross-priming with mycobacterial antigens acquired from infected macrophages. Objective : To determine the extent and time course of infection of lung DCs following intranasal inoculation of BALB/c mice with green fluorescent protein (GFP) tagged Bacillus Calmette-Guerin (BCG). Results : A fraction of GFP-BCG infected lung cells were classified as monocytic DCs with the CD11c + IA + 33D1 + CD8a − phenotype. These cells represented 5–18% of the tot…
Malassezia restricta Pneumonia in Solid Organ Transplant Recipients: First Report of Two Cases
2021
Emerging fungal infections are a major challenge in solid organ transplantation (SOT) and are associated with high morbidity and mortality. We report two cases of Malassezia restricta pneumonia in SOT recipients. Infections were diagnosed with molecular analysis and histology. Patients were treated with antifungal therapy and have fully recovered.
A multiscale X-ray phase-contrast tomography dataset of whole human left lung
2021
ABSTRACTTechnological advancements in X-ray imaging using bright and coherent synchrotron sources now allows to decouple sample size and resolution, while maintaining high sensitivity to the microstructure of soft, partially dehydrated tissues. The recently developed imaging technique, hierarchical phase-contrast tomography, is a comprehensive approach to address the challenge of organ-scale (up to tens of centimeters) soft tissue imaging with resolution and sensitivity down to the cellular level. Using this technique, we imaged ex vivo an entire human left lung at an isotropic voxel size of 25.08 μm along with local zooms down to 6.05 - 6.5 μm and 2.45 - 2.5 μm in voxel size. The high tiss…
ESPERIRE MIMETICO E RAZIONALITÀ NEL MODELLO ADORNIANO DI RAPPORTO MENTE-MONDO.
2014
Il saggio ricostruisce il ruolo cognitivo e razionale della mimesi nel modello adorniano di conoscenza come “differenziazione”. Vi è proposta un’interpretazione della capacità del “pensare per costellazioni” e del linguaggio di “cogliere la cosa”, che ne evidenzia la lontananza dal “vecchio realismo della rappresentazione oggettiva (der alte Abbildrealismus)”. Esso mira anche a rendere esplicito come il modello adorniano di conoscenza sia in grado di dar conto di alcune recenti acquisizioni neurofisiologiche su un livello mimetico di rapporto mente-mondo, e come esso contribuisca ad una convincente interpretazione, razionalista ed antiintellettualista ad un tempo, di alcune loro implicazion…
Computational analysis of lung deformation after murine pneumonectomy. [corrected].
2012
In many mammalian species, the removal of one lung (pneumonectomy) is associated with the compensatory growth of the remaining lung. To investigate the hypothesis that parenchymal deformation may trigger lung regeneration, we used microCT scanning to create 3-dimensional finite element geometric models of the murine lung pre- and post-pneumonectomy (24 hours). The structural correspondence between models was established using anatomic landmarks and an iterative computational algorithm. When compared with the pre-pneumonectomy lung, the post-pneumonectomy models demonstrated significant translation and rotation of the cardiac lobe into the post-pneumonectomy pleural space. 2-dimensional maps…
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatme…
2016
NSC12 is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity. It was identified by virtual screening from a NCI small molecule library, but no data were available about its synthesis, stereochemistry, and physicochemical properties. We report here a synthetic route that allowed us to characterize and unambiguously identify the structure of the active compound by a combination of NMR spectroscopy and in silico conformational analysis. The synthetic protocol allowed us to sustain experiments aimed at assessing its therapeutic potential for the treatment of FGF-dependent lung cancers. A crucial step in the synthesis generated a c…
Understanding the Mechanism of the Intramolecular Stetter Reaction. A DFT Study
2012
The mechanism of the N-heterocyclic carbene (NHC)-catalyzed intramolecular Stetter reaction of salicylaldehyde 1 to yield chromanone 3 has been theoretically studied at the B3LYP/6-31G** level. This NHC-catalyzed reaction takes place through six elementary steps, which involve: (i) formation of the Breslow intermediate IN2; (ii) an intramolecular Michael-Type addition in IN2 to form the new C-C s bond; and (iii) extrusion of the NHC catalyst from the Michael adduct to yield chromanone 3. Analysis of the relative free energies in toluene indicates that while formation of Breslow intermediate IN2 involves the rate-determining step of the catalytic process, the intramolecular Michael-type addi…
L'isolato di Valdesi. Tra superfici e profondità
2009
Il volume dà conto dei risultati di un complesso lavoro di studio e di ricerca derivante dall'incarico attribuito dal Comune di Palermo al Dipartimento di Storia e Progetto nell'Architettura e svolto dal gruppo di lavoro composto dai curatori. Il lavoro prende le mosse dall'elaborazione di uno "Studio di inquadramento territoriale per interventi di riqualificazione a Mondello" che costituisce il cardine tra la pianificazione sulla borgata di Mondello, vigente e di futura attuazione, e tutto l'insieme di ipotesi e aspettative che si è inteso promulgare attraverso la definizione di un bando per un Concorso Internazionale di idee e le riflessioni successive sugli esiti che da questo sono deriv…