Search results for "MAC"
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Działalność animacyjna liderów Lokalnej Grupy Działania w środowisku wiejskim (przykład Śląska Opolskiego)
2016
Artykuł omawia modernizację obszarów wiejskich Śląska Opolskiego w perspektywie działań animacyjnych podejmowanych przez liderów lokalnych skupionych w Lokalnej Grupie Działania. Przeanalizowano – na podstawie badań terenowych – ich współpracę z Fundacją Euro-Country – partnerstwo dla zrównoważonego rozwoju obszarów wiejskich, która wspólnie z nimi wdraża lokalną strategię rozwoju, budując lokalne partnerstwo i integrując społeczności wiejskie wokół idei zrównoważonego i wielofunkcyjnego rozwoju.
La prescrizione dei farmaci "off label". Presupposti normativi e regolatori
2013
L’ASSIMILAZIONE IN AMBITO SPORTIVO DELLA SOMMINISTRAZIONE OFF-LABEL AL DOPING, SPUNTI GIURIDICI ED ETICI
2015
This paper offers an analysis about the issue of off-label drugs use in Italy, focusing on the sport area and on the role of the State. In particular interconnections and divergences with anti-doping regulation will be addressed, making some reflections about the partial lack of regulation.
Kísérlet egy összehasonlító vizsgálatra : a nyelvi tájkép dél-szlovákiai, székelyföldi és kárpátaljai falvakban
2017
A tanulmany hat falu nyelvi tajkepenek altalanos jellemzeset adja, es az eredmenyeket osszehasonlitja egyreszt egymassal, masreszt korabbi, az altalanos nyelvi helyzetet osszefoglalo munkakkal. Egy-egy olyan del-szlovakiai, szekelyfoldi es karpataljai falu kerul bemutatasra, ahol a telepulesen beluli szobeli kommunikacio nyelve egyontetűen a magyar, illetve egy-egy olyan falu, melyet szobeli ketnyelvűseg jellemez. A tanulmany masodik resze a felirattipusokat, ezek ketnyelvűseget elemzi. Vegul osszehasonlitjuk az eredmenyeket azzal az altalanos keppel, amit egyeb szociolingvisztikai kutatasok alapjan alkothatunk az adott regiokban elő magyarok nyelvhasznalatarol. Kulcsszavak: nyelvi tajkep, …
Terroryzm islamski a bezpieczeństwo globalne
2016
Gwałtowny wzrost liczby zamachów terrorystycznych na przełomie XX i XXI w. w wymiarze międzynarodowych wyraźnie wskazuje na zwiększenie aktywności ugrupowań terrorystycznych o charakterze religijnym, który kojarzony był z ugrupowaniami terrorystycznymi o rodowodzie islamskim. Aktywność tych ugrupowań była ukierunkowana na przeprowadzanie różnego typu ataków w wielu częściach świata, co w naturalny sposób odczytane było jako prowadzenie działań terrorystycznych w skali globalnej. Z jednej strony ataki terrorystyczne powodowały liczne ofiary wśród ludności cywilnej oraz ogromne straty materialne, z drugiej fundamentaliści islamscy osiągnęli inny bardzo ważny dla nich cel propagandowy – wywoła…
Assessment of genetically modified oilseed rape MS8, RF3 and MS8×RF3 for renewal of authorisation under regulation (EC) No 1829/2003 (application EFS…
2017
Efsa Panel On Genetically Modified Organisms (gmo)Opinion scientificRequestor: European CommissionQuestion number: EFSA-Q-2016-00569; Following the submission of application EFSA-GMO-RX-004 under Regulation (EC) No 1829/2003 from Bayer CropScience, the Panel on Genetically Modified Organisms of the European Food Safety Authority (GMO Panel) was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application of the genetically modified (GM) herbicide-tolerant oilseed rape MS8, RF3 and MS89RF3. The data received in the context of this renewal application contain post-market environmental monitoring reports, systematic searches and…
Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery
2019
In order to evaluate the potential of a technology platform based on hyaluronan copolymers grafted with propargylated ferulate fluorophores (HA-FA-Pg) in the development of drug delivery systems, the propargyl groups of HA-FA-Pg derivatives were employed with oleic acid (OA) or stearic acid (SA) residues across a biocompatible hexa(ethylene glycol) (HEG) spacer. The designed materials (i.e., HA-FA-HEG-OA or HA-FA-HEG-SA) showed clear-cut aggregation features in an aqueous environment, as confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM), generating nanoaggregate systems. In fact, HA-FA-HEG-OA and HA-FA-HEG-SA derivatives showed the property to create sel…
Increasing Yield and Antioxidative Performance of Litchi Pericarp Procyanidins in Baked Food by Ultrasound-Assisted Extraction Coupled with Enzymatic…
2018
Extraction with organic solvents is a traditional method to isolate bioactive compounds, which is energy-wasting and time-consuming. Therefore, enzyme and ultrasound treatments were combined to assist the extraction of oligomeric procyanidins from litchi pericarp (LPOPC), as an innovative approach to replace conventional extraction methods. Under optimum conditions (enzyme concentration 0.12 mg/mL, ultrasonic power 300 W, ultrasonic time 80 min, and liquid/solid ratio 10 mL/g), the yield of LPOPC could be improved up to 13.5%. HPLC analysis indicated that the oligomeric procyanidins (OPC) content of LPOPC from proposed extraction was up to 89.6%, mainly including (&minus
Oligonucleotide-capped nanoporous anodic alumina biosensor as diagnostic tool for rapid and accurate detection of Candida auris in clinical samples.
2021
[EN] Candida auris has arisen as an important multidrug-resistant fungus because of several nosocomial outbreaks and elevated rates of mortality. Accurate and rapid diagnosis of C. auris is highly desired; nevertheless, current methods often present severe limitations and produce misidentification. Herein a sensitive, selective, and time-competitive biosensor based on oligonucleotide-gated nanomaterials for effective detection of C. auris is presented. In the proposed design, a nanoporous anodic alumina scaffold is filled with the fluorescent indicator rhodamine B and the pores blocked with different oligonucleotides capable of specifically recognize C. auris genomic DNA. Gate opening modul…
The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer
2021
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer affinity entirely depends on its tertiary structure and charge distribution. Therefore, length and structure optimization are essential for increasing aptamer specificity and affinity. Here, we present a general optimization procedure for finding the most populated atomistic structures of DNA aptamers. Based on the existed aptamer LC-18 for lung adenocarcinoma, a new truncated LC-18 (LC-18t) aptamer LC-18t was developed. A three-dimensional (3D) shape of LC-18t was reported based on small-angle X-ray scattering…