Search results for "MACROMOLECULAR"
showing 10 items of 944 documents
A time-geographic approach for visualizing the paths of intervention for persons with severe mental illness
2017
Living conditions for persons with severe mental illness (SMI) in Sweden have changed dramatically in recent decades, mainly due to the closure of mental hospitals in the 1990s and the subsequent d ...
Evaluation of Safety, Tolerability and Efficacy of Temsirolimus in Patients with Relapsed or Refractory Mantle Cell Lymphoma (REL/REFR MCL) in the Us…
2012
ABSTRACT Background Temsirolimus (TEMS), an mTOR-inhibitor, is approved the EU for the treatment of patients (pts) with relapsed or refractory MCL (rel/refr). A pivotal study demonstrated significantly longer progression free survival with TEMS (175mg weekly for 3 weeks followed by 75mg weekly) in rel/refr MCL pts compared to investigatoŕs choice therapy (4.8 mo vs 1.9 mo; P = .0009). To better identify safety and efficacy of TEMS in an unselected patient population during clinical routine a prospective non-interventional study with TEMS in rel/refr MCL-pts was started. Here we report on interim results of the study. Methods A registry for rel/refr MCL pts treated with TEMS was started in G…
New Perspective in Atrial Fibrillation
2020
International audience; Despite a large number of publications on this subject, the pathophysiological mechanisms involved in atrial fibrillation (AF) onset and recurrence are uncertain [...]
Clozapine-related drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a systematic review.
2020
The Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a severe, multiorganic, and potentially life-threatening drug-induced hypersensitivity reaction, linked to several common drugs, including antiepileptics, antibiotics, and several psychotropic drugs, including clozapine. Due to the importance of clozapine in the management of treatment-resistant schizophrenia, a systematic review and characterization of clozapine-related DRESS syndrome is long overdue.This systematic review was conducted following PRISMA guidelines. PubMed, Embase, PsychINFO, and the Cochrane Library databases were independently reviewed up to 1 November 2019 for articles reporting clozapine-relat…
Materiell og profesjonell stigmatisering av mennesker med sykelig overvekt
2017
The aim of this study is to show how people suffering from severe obesity mightexperience stigmatization. We interviewed 6 persons recruited from aNorwegian rehabilitation center, specialized in lifestyle intervention in severeobesity. We found that the participants suffering from severe obese experiencedstigmatization and thus felt that they a) did not fit into the materiel world and b)experienced a lack of respect from health care professionals. The results arediscussed according to how contemporary symbols are embedded in oursurroundings and in our bodies. The conclusion underlines severe obesity as acomplex problem which is strengthened by rooms and interior designed for idealsizes. The…
The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment
2020
The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified because of its key role in the regulation of glycogen synthesis. However, it is now well-established that GSK-3 performs critical functions in many cellular processes, such as apoptosis, tumor growth, cell invasion, and metastasis. Aberrant GSK-3 activity has been associated with many human diseases, including cancer, highlighting its potential therapeutic relevance as a target for anticancer therapy. Recently, newly emerging data have demonstrated the pivotal role of GSK-3 in the anticancer immune response. In the last few years, many GSK-3 inhibitors have been developed, and some are currently being te…
2016
Background Contractile myofibroblasts (MFs) accumulate in the joint capsules of patients suffering from posttraumatic joint stiffness. MF activation is controlled by a complex local network of growth factors and cytokines, ending in the increased production of extracellular matrix components followed by soft tissue contracture. Despite the tremendous growth of knowledge in this field, inconsistencies remain in practice and prevention.
Lymphatic vessels of the dura mater: a new discovery?
2015
Aspelund et al. discover the presence of a lymphatic vessel network in the dura mater of the mouse brain and show that these dural lymphatic vessels are important for the clearance of macromolecules from the brain.
Ritz Solution for Transient Analysis of Variable-Stiffness Shell Structures
2020
The dynamic response of thin-walled structures is driven by mass and stiffness distribution. As such, variable-stiffness (VS) composites offer opportunities to tune structural dynamic responses. To this extent, efficient analysis tools become increasingly important for structural analysis and design purposes. In this work, an efficient and versatile Ritz method for free vibrations and linear transient analysis of VS doubly curved shell structures is presented. VS shell structures are modeled as an assembly of shell-like domains. The shell kinematics is based on the first-order shear deformation theory, and no further assumption is made on the shallowness or on the thinness of the structure.…
CMC is more than a measure of corticospinal tract integrity in acute stroke patients
2021
In healthy subjects, motor cortex activity and electromyographic (EMG) signals from contracting contralateral muscle show coherence in the beta (15-30 Hz) range. Corticomuscular coherence (CMC) is considered a sign of functional coupling between muscle and brain. Based on prior studies, CMC is altered in stroke, but functional significance of this finding has remained unclear. Here, we examined CMC in acute stroke patients and correlated the results with clinical outcome measures and corticospinal tract (CST) integrity estimated with diffusion tensor imaging (DTI). During isometric contraction of the extensor carpi radialis muscle, EMG and magnetoencephalographic oscillatory signals were re…