Search results for "MAI"
showing 10 items of 6279 documents
Seeking the Source of Catalytic Efficiency of Lindane Dehydrochlorinase, LinA.
2020
Herein we present the results of an in-depth simulation study of LinA and its two variants. In our analysis, we combined the exploration of protein conformational dynamics with and without bound substrates (hexachlorocyclohexane (HCH) isomers) performed using molecular dynamics simulation followed by the extraction of the most frequently visited conformations and their characteristics with a detailed description of the interactions taking place in the active site between the respective HCH molecule and the first shell residues by using symmetry-adapted perturbation theory (SAPT) calculations. A detailed investigation of the conformational space of LinA substates has been accompanied by desc…
Measuring frequency domain granger causality for multiple blocks of interacting time series
2011
In the past years, several frequency-domain causality measures based on vector autoregressive time series modeling have been suggested to assess directional connectivity in neural systems. The most followed approaches are based on representing the considered set of multiple time series as a realization of two or three vector-valued processes, yielding the so-called Geweke linear feedback measures, or as a realization of multiple scalar-valued processes, yielding popular measures like the directed coherence (DC) and the partial DC (PDC). In the present study, these two approaches are unified and generalized by proposing novel frequency-domain causality measures which extend the existing meas…
People with memory illnesses and their spouses as actors in the hybrid care model
2023
Objective: The study analysed how its participants positioned themselves and other people as actors in daily life, and what matters they portrayed as meaningful in seeking and receiving support in daily life. Background: Family care has traditionally played an important role in elder care in Finland. Current policy goals will further increase the importance of family care, yet research on how people with memory illnesses and their spouses perceive care arrangements is scarce. Method: The study drew from theory of relational agency and positioning theory. The data came from semi-structured, in-depth interviews (10) of home-dwelling people diagnosed with a memory illness and their spouses. Th…
VIZUALINIS MOKTYTOJO ĮVAIZDIS: LYGINAMASIS TYRIMAS
2013
Dr. paed., Instituteof Educational Sciences, University of Latvia, Latvia. E-mail: iveta.kestere@lu.lv Address: Laimdotas 37, Rīga LV1006, Latvia Phone +371 29496660; +32 473 63 37 98PhD, Graduate School of Education, North West University, South Africa. E-mail: Charl.Wolhuter@nwu.ac.za Address: North-West University, Private Bag X 6001, Potchefstroom 2520, South AfricaPhD, Educational Sciences Department, Yeditepe University, Turkey. E-mail: ricardolozanov@gmail.comStraipsnyje „Vizualinis mokytojo įvaizdis: lyginamasis tyrimas“ pateikiami tyrimo, atlikto dešimtyje šalių – Anglijoje, Pietų Afrikoje, Serbijoje, Slovėnijoje, Graikijoje, Bulgarijoje, Latvijoje, Turkijoje, Pakistane ir Meksi…
Complete nonlinear polarization control in an optical fiber system.
2010
International audience; We consider the counterpropagating interaction of a signal and a pump beam in an isotropic optical fiber. On the basis of recently developed mathematical techniques, we show that an arbitrary state of polarization of the signal beam can be converted into any other desired state of polarization. On the other hand, an unpolarized signal beam may be repolarized into two specific states of polarization, without loss of energy. Both processes of repolarization and polarization conversion may be controlled by adjusting the polarization state of the backward pump.
CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells
2018
CD38 is overexpressed by multiple myeloma cells and has emerged as a target for therapeutic antibodies. Nanobodies are soluble single domain antibody fragments derived from the VHH variable domain of heavy chain antibodies naturally occurring in camelids. We previously identified distinct llama nanobodies that recognize three non-overlapping epitopes of the extracellular domain of CD38. Here, we fused these VHH domains to the hinge, CH2, and CH3 domains of human IgG1, yielding highly soluble chimeric llama/human heavy chain antibodies (hcAbs). We analyzed the capacity of these hcAbs to mediate complement-dependent cytotoxicity (CDC) to CD38-expressing human multiple myeloma and Burkitt lymp…
The BIM (Building Information Modeling)-Based Approach for Road Pavement Maintenance
2019
The recent developments of road pavement survey technologies guarantee acquisition of detailed data regarding the main functional and structural indicators, at a very high frequency and levels of accuracy and precision unconceivable few years ago. The relevant information, regarding surface distresses too, is thus available in economical, high-speed and high-resolution forms, with limited disturbance on traffic and road agencies issues. However, the availability of such a mass of data poses interesting questions concerning the most efficient processing and analysis methods, for optimizing maintenance operation planning. Unfortunately, the PMS adoption is not very common and widespread, as t…
Les phénols de la lignine et le 13C, traceurs de l'origine des matières organiques du sol
2001
Abstract In spodosols of Gascony (France), conversion of maritime pine stands into maize cropping leads to an incorporation of maize organic matter, which changed the isotopic (δ13C) and phenolic signature in A and L horizons of soil. Hydrolysis of phenol lignin in forests and cultivated soils showed the predominance of vanillic units under forest and the early but moderate incorporation of cinnamic acids. Incorporation of syringic units appeared higher, related to a large maize production of stable syringic phenols. Syringic units represented a long-term marker of maize inputs in soils, whereas vanillic units revealed the degradation of forest organic matter.
Oppisopimuksella turvavalvojaksi? : tutkimus vammaisten ja vajaakuntoisten henkilöiden työllistymisestä avoimille työmarkkinoille
2000
Suomalaisten käsityksiä maatalousmaiseman muutoksesta ja maatalouden ekosysteemipalveluista
2015
Tutkimuksen tarkoituksena on suomalaisten maatalousmaisemaan ja maatalouden ekosysteemipalveluihin liittyvien käsitysten tutkiminen. Maatalousmaisema on Suomessa jatkuvassa muutoksessa, ja maisemaan liittyvät näkemykset ovat usein ristiriidassa keskenään. Suomen ratifioiman eurooppalaisen maisemayleissopimuksen mukaan kansalaisten maisema-arvostuksia tulisi huomioida maisemaa koskevassa suunnittelussa ja päätöksenteossa. Maatalousmaisemaa voidaan lähestyä myös sen tarjoamien ekosysteemipalvelujen eli hyötyjen avulla. Tutkimuksessa tarkastellaan, mitä ekosysteemipalveluja ja minkä verran suomalaiset arvioivat maatalousmaiseman tuottavan. Lisäksi tutkitaan, miten kansalaiset yhtäältä ennakoiv…