Search results for "MAM"
showing 10 items of 1679 documents
Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Neg…
2015
BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal to its ED50 at 72 h (117 μM). Exposure of cells to BC-11, either pre-absorbed with a soluble preparation of the N-terminal fragment of urokinase-plasminogen activator (uPa), or in co-treatment with two different EGFR inhibitors, indicated that: (i) BC-11 acts via binding to the N-terminus of the enzyme where uPa- and EGF receptor-recognizing sites are present, thereby abrogating the growth-sustaining effect resulting from receptor binding
Subcellular distribution of calpain-1 and calpain-2 as a key event for calpain-mediated functions in physiological and neoplastic mammary models
2019
Calpains are a family of calcium-dependent proteases, which modulate their substrates rather than degrade them in such a way that modifies them. Calpains deregulations have been determined as an aggravating factor of different diseases, including cancer. Nevertheless, there are no clear records about the particular contribution of each calpain isoform in physiological processes and how these isoforms are deregulated in pathological conditions. In vivo, each calpain isoform recognizes specific proteins as substrates, and it has been suggested that calpains subcellular localization might determine their substrate recognition, and consequently their functions. In the present study we have expl…
Comparative Study of Feature classification Methods for Mass Lesion Recognition in Digitized Mammograms
2007
In this work a comparison of different classification methods for the identification of mass lesions in digitized mammograms is performed. These methods, used in order to develop Computer Aided Detection (CAD) systems, have been implemented in the framework of the MAGIC-5 Collaboration. The system for identification of mass lesions is based on a three-step procedure: a) preprocessing and segmentation, b) region of interest (ROI) searching, c) feature extraction and classification. It was tested on a very large mammographic database (3369 mammographic images from 967 patients). Each ROI is characterized by eight features extracted from a co-occurrence matrix containing spatial statistics inf…
Classifier trained on dissimilarity representation of medical pattern: A comparative study.
2005
In this paper we investigate the feasibility of some typical techniques of pattern recognition for the classification of medical examples. The learning of the classifiers is not made in the traditional features space but it can be made by constructing decision rules on dissimilarity (distance) representations. In such a recognition process a new object is described by its distances to (a subset of) the training samples. Purpose of this work is the development of an automatic classification system which could be useful for radiologists in the investigation of breast cancer. The software has been designed in the framework of the MAGIC-5 collaboration. In the automatic classification system th…
Évaluation neuro-éthologique du comportement alimentaire olfacto-guidé du lapin nouveau-né
2012
Le document qui a justifié la délivrance du diplôme est en cours de traitement par la bibliothèque de l'établissement de soutenance.; L'olfaction est une sensorialité essentielle aux mammifères, dès les stades les plus précoces du développement. Ainsi, chez le lapin européen (Oryctolagus cuniculus), les nouveau-nés interagissent avec la mère et s'orientent vers ses tétines suite à la perception de signaux odorants appris périnatalement, ou d'au-moins un signal à l'action prédisposée, la phéromone mammaire (PM; molécule contenue dans le lait de lapine). La PM est très fortement réactogène au cours des 15 premiers jours postnatals, période d'alimentation lactée exclusive. Elle déclenche alors…
Pheromone-induced odor learning modifies Fos expression in the newborn rabbit brain.
2013
Research report; International audience; Associative learning contributes crucially to adjust the behavior of neonates to the permanently changing environment. In the European rabbit, the mammary pheromone (MP) excreted in milk triggers sucking behavior in newborns, and additionally promotes very rapid learning of initially neutral odor cues. Such stimuli become then as active as the MP itself to elicit the orocephalic motor responses involved in suckling. In this context, the rabbit is an interesting model to address the question of brain circuits early engaged by learning and memory. Here, we evaluated the brain activation (olfactory bulb and central regions) induced in 4-day-old pups by …
Relazioni tra sindrome metabolica e carcinoma mammario: osservazioni da una casistica ambulatoriale
1997
La calpaína-2 en el núcleo de células de cáncer de mama: De la identificación de dianas nucleares a la función
2022
La calpaína-2 (CAPN2) es una cisteín-proteasa dependiente de Ca2+ de distribución ubicua en mamíferos. Proteoliza de forma limitada sus sustratos, modificando su función, distribución, interacción con otras proteínas o regulación. Se ha postulado que la gran variedad de funciones de la CAPN2 depende de su distribución subcelular y de su acceso a sustratos específicos. El papel de la CAPN2 en la membrana celular o en el citosol se ha estudiado en diferentes tipos celulares para explicar funciones como la migración, adhesión o muerte celular. Sin embargo, las funciones de la CAPN2 nuclear no se han estudiado en profundidad. Identificar los componentes dependientes de la CAPN2 en el núcleo, ay…
MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b
2016
// Giuseppina Roscigno 1, 2 , Cristina Quintavalle 1, 2 , Elvira Donnarumma 3 , Ilaria Puoti 1 , Angel Diaz-Lagares 4 , Margherita Iaboni 1 , Danilo Fiore 1 , Valentina Russo 1 , Matilde Todaro 5 , Giulia Romano 6 , Renato Thomas 7 , Giuseppina Cortino 7 , Miriam Gaggianesi 5 , Manel Esteller 4 , Carlo M. Croce 6 , Gerolama Condorelli 1, 2 1 Department of Molecular Medicine and Medical Biotechnology, “Federico II” University of Naples, Naples, Italy 2 IEOS-CNR, Naples, Italy 3 IRCCS-SDN, Naples, Italy 4 Epigenetic and Cancer Biology Program (PEBC) IDIBELL, Hospital Duran I Reynals, Barcelona, Spain 5 Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Lab…
Data from: Temporal dynamics of Puumala hantavirus infection in cyclic populations of bank voles
2017
Understanding the dynamics of zoonotic pathogens in their reservoir host populations is a prerequisite for predicting and preventing human disease epidemics. The human infection risk of Puumala hantavirus (PUUV) is highest in northern Europe, where populations of the rodent host (bank vole, Myodes glareolus) undergo cyclic fluctuations. We conducted a 7-year capture-mark-recapture study to monitor seasonal and multiannual patterns of the PUUV infection rate in bank vole populations exhibiting a 3-year density cycle. Infected bank voles were most abundant in mid-winter months during years of increasing or peak host density. Prevalence of PUUV infection in bank voles exhibited a regular, seas…