Search results for "MAMMALS"

showing 10 items of 301 documents

Neuronal-Type NO Synthase: Transcript Diversity and Expressional Regulation

1998

Of the three established isoforms of NO synthase, the gene for the neuronal-type enzyme (NOS I) is by far the largest and most complicated one. The genomic locus of the human NOS I gene is located on chromosome 12 and distributed over a region greater than 200 kb. The nucleotide sequence corresponding to the major neuronal mRNA transcript is encoded by 29 exons. The full-length open reading frame codes for a protein of 1434 amino acids with a predicted molecular weight of 160.8 kDa. However, both in rodents and in humans, multiple, tissue-specific or developmentally regulated NOS I mRNA transcripts have been reported. They arise from the initiation by different transcriptional units contain…

Gene isoformCancer ResearchTranscription GeneticPolyadenylationPhysiologyClinical BiochemistryNitric Oxide Synthase Type IILocus (genetics)BiologyBiochemistryGene Expression Regulation EnzymologicExonGene expressionTranscriptional regulationAnimalsHumansRNA MessengerPromoter Regions GeneticGeneSequence DeletionMammalsGeneticsChromosomes Human Pair 12Gene Expression Regulation DevelopmentalAlternative SplicingOpen reading frameNitric Oxide SynthaseNitric Oxide
researchProduct

DNA sequence and pattern of expression of the sea urchin (Paracentrotus lividus) alpha-tubulin genes.

1989

To study the molecular aspects of the regulation of transcription of a multigene family, we have isolated and sequenced cDNA and genomic clones coding for the alpha-tubulin of the sea urchin Paracentrotus lividus. Two cDNA clones, P alpha 10 and P alpha 4, contain respectively the coding information for 391 C-terminal and for 338 N-terminal amino acids of the 452 residues that constitute the complete protein. They show silent nucleotide substitutions only, suggesting that P alpha 10 and P alpha 4 represent the cloned copies of two allelic gene transcripts, which encode for two alpha-tubulin isoforms with identical amino acid sequence in the region of the overlap. The comparison of the predi…

Gene isoformSequence analysisMolecular Sequence DataRestriction MappingParacentrotus lividusTranscription (biology)TubulinComplementary DNAGeneticsAnimalsAmino Acid SequenceRNA MessengerPeptide sequenceGeneMammalsbiologyBase SequenceRNACell BiologyDNAbiology.organism_classificationMolecular biologyBiological EvolutionGene Expression RegulationMultigene FamilySea UrchinsDNA ProbesDevelopmental BiologyMolecular reproduction and development
researchProduct

Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals

2011

Claudin-18 isoform 2 (CLDN18.2) is one of the few members of the human claudin family of tight junction molecules with strict restriction to one cell lineage. The objective of the current study was to compare molecular structure and tissue distribution of this gastrocyte specific molecule in mammals. We show here that the CLDN18.2 protein sequence is highly conserved, in particular with regard to functionally relevant domains in mouse, rat, rabbit, dog, monkey and human and also in lizards. Moreover, promoter regions of orthologs are highly homologous, including the binding site of the transcription factor cyclic AMP-responsive element binding protein (CREB), which is known to regulate acti…

Gene isoformmiceMolecular Sequence DataGene Expressionmolecular structureMammals/geneticsBiologyphylogenyRATSConserved sequenceEvolution MolecularDogsProtein Isoforms/geneticsSequence Homology Nucleic AcidGene expressionGeneticsProtein IsoformsAnimalsTissue DistributionAmino Acid SequenceMembrane Proteins/geneticsBinding sitePromoter Regions GeneticClaudinGeneTranscription factorConserved SequenceGastric Mucosa/metabolismMammalsRegulation of gene expressionGeneticsBinding SitesBase SequenceStomachStomach/cytologyMembrane ProteinsCREB-Binding Protein/metabolismHaplorhiniGeneral MedicineCREB-Binding ProteinGene Expression RegulationGastric MucosaOrgan SpecificityMultigene FamilyClaudinsRabbitsGene
researchProduct

Comparative Cytogenetics Allows the Reconstruction of Human Chromosome History: The Case of Human Chromosome 13

2019

Comparative cytogenetics permits the identification of human chromosomal homologies and rearrangements between species, allowing the reconstruction of the history of each human chromosome. The aim of this work is to review evolutionary aspects regarding human chromosome 13. Classic and molecular cytogenetics using comparative banding, chromosome painting, and bacterial artificial chromosome (BAC) mapping can help us formulate hypotheses about chromosome ancestral forms; more recently, sequence data have been integrated as well. Although it has been previously shown to be conserved when compared to the ancestral primate chromosome, it shows a degree of rearrangements in some primate taxa; fu…

Geneticsmedicine.medical_specialtyChromosome (genetic algorithm)InformationSystems_INFORMATIONSTORAGEANDRETRIEVALData_FILESCytogeneticsmedicineSettore BIO/08 - AntropologiaBiologyFish evolution mammals human syntenyGeneralLiterature_REFERENCE(e.g.dictionariesencyclopediasglossaries)Chromosome 13
researchProduct

7E olfactory receptor gene clusters and evolutionary chromosome rearrangements

2005

Olfactory receptor (OR) genes of the 7E subfamily have been duplicated to multiple regions throughout the human genome. Segmental duplications containing 7E OR genes have been associated with both pathological and evolutionary chromosome rearrangements. Many of these breakpoint regions coincide with breaks of chromosomal synteny in the mouse, rat and/or chicken genomes. Collectively, these data suggest that 7E OR-containing regions represent hot spots of genomic instability.    

Genome instabilityChromosomes Artificial BacterialGenome evolutionBiologyReceptors OdorantGenomeEvolution MolecularGene DuplicationGeneticsmedicineAnimalsHumansMolecular BiologyGeneIn Situ Hybridization FluorescenceGenetics (clinical)SyntenySegmental duplicationGene RearrangementMammalsGeneticsGenomeOlfactory receptorGenome HumanChromosome Mappingmedicine.anatomical_structureMultigene FamilyHuman genomeCytogenetic and Genome Research
researchProduct

Spatial analysis of the relationship between mortality from cardiovascular and cerebrovascular disease and drinking water hardness

2004

Journal Article; Research Support, Non-U.S. Gov't; Reproduced with permission from Environmental Health Perspectives. Previously published scientific papers have reported a negative correlation between drinking water hardness and cardiovascular mortality. Some ecologic and case-control studies suggest the protective effect of calcium and magnesium concentration in drinking water. In this article we present an analysis of this protective relationship in 538 municipalities of Comunidad Valenciana (Spain) from 1991-1998. We used the Spanish version of the Rapid Inquiry Facility (RIF) developed under the European Environment and Health Information System (EUROHEIS) research project. The strateg…

GerontologyMaleMini-Monograph: Information SystemsHealth Toxicology and MutagenesisWater supply:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Disease:Health Care::Environment and Public Health::Public Health::Sanitation::Sanitary Engineering::Water Supply [Medical Subject Headings]Magnesio:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]PreescolarMediana EdadReference ValuesExposición a Riesgos AmbientalesMedicineCluster AnalysisMagnesiumMasculinoChildEnfermedades Cardiovascularesgeographic information systems:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Weights and Measures::Reference Values [Medical Subject Headings]AdultoAguaEpidemiologic SurveillanceEnvironmental exposureMiddle AgedHumanos:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure [Medical Subject Headings]Abastecimiento de aguarelative risk:Information Science::Information Science::Information Storage and Retrieval::Databases as Topic::Databases Factual::Geographic Information Systems [Medical Subject Headings]Cardiovascular DiseasesNiñoChild Preschool:Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders [Medical Subject Headings]Female:Named Groups::Persons::Age Groups::Infant [Medical Subject Headings]Risk assessmentAdulthierarchical spatial modelsAdolescentAncianoSistemas de Información Geográfica:Check Tags::Male [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Cluster Analysis [Medical Subject Headings]:Named Groups::Persons::Age Groups::Infant::Infant Newborn [Medical Subject Headings]Risk AssessmentCalcioWater Supply:Chemicals and Drugs::Inorganic Chemicals::Metals::Metals Alkaline Earth::Calcium [Medical Subject Headings]Environmental health:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]:Chemicals and Drugs::Inorganic Chemicals::Metals::Metals Light::Magnesium [Medical Subject Headings]Humans:Chemicals and Drugs::Inorganic Chemicals::Hydroxides::Water [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings]:Diseases::Cardiovascular Diseases [Medical Subject Headings]Socioeconomic status:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]Agedbusiness.industry:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Assessment [Medical Subject Headings]Public Health Environmental and Occupational HealthInfant NewbornInfantWaterLactanteEnvironmental ExposureValores de ReferenciaAnálisis por ConglomeradosEstudios Epidemiológicosenvironmental epidemiologyCerebrovascular DisordersEpidemiologic StudiesTrastornos Cerebrovasculares:Check Tags::Female [Medical Subject Headings]Relative riskspatial smoothingCalciumbusinessMedición de Riesgo:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies [Medical Subject Headings]Environmental epidemiology
researchProduct

Long-Term Behavioral Programming Induced by Peripuberty Stress in Rats Is Accompanied by GABAergic-Related Alterations in the Amygdala

2014

Stress during childhood and adolescence is a risk factor for psychopathology. Alterations in γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, have been found following stress exposure and fear experiences and are often implicated in anxiety and mood disorders. Abnormal amygdala functioning has also been detected following stress exposure and is also implicated in anxiety and social disorders. However, the amygdala is not a unitary structure; it includes several nuclei with different functions and little is known on the potential differences the impact of early life stress may have on this system within different amygdaloid nuclei. We aimed here to evaluate pote…

Glutamate decarboxylaselcsh:MedicineNeural HomeostasisAnxietyBiochemistryMechanical Treatment of SpecimensBasal (phylogenetics)Behavioral Neuroscience0302 clinical medicineAdolescent PsychiatryMolecular Cell BiologyMedicine and Health SciencesPsychologyReceptorlcsh:Sciencegamma-Aminobutyric AcidCellular Stress ResponsesMammalsChild Psychiatry0303 health sciencesMultidisciplinaryBehavior AnimalGlutamate DecarboxylaseNeurochemistryNeurotransmittersAnimal ModelsAmygdalaAnxiety Disordersmedicine.anatomical_structureElectroporationSpecimen DisruptionCell ProcessesVertebratesAnxietyGABAergicmedicine.symptommedicine.drugResearch Articlemedicine.medical_specialtyComputer and Information SciencesNeural NetworksPsychological StressNeuropsychiatric DisordersBiologyResearch and Analysis MethodsAmygdalaRodentsgamma-Aminobutyric acid03 medical and health sciencesModel OrganismsDevelopmental NeuroscienceNeuropsychologyMental Health and PsychiatrymedicineAnimalsInterpersonal RelationsRats WistarPsychiatry030304 developmental biologyBehaviorMood Disorderslcsh:RBody WeightPubertyOrganismsBiology and Life SciencesCell Biologymedicine.diseaseReceptors GABA-ARatsMood disordersnervous systemSpecimen Preparation and TreatmentExploratory Behaviorlcsh:QMolecular NeuroscienceNeuroscience030217 neurology & neurosurgeryStress PsychologicalNeurosciencePLoS ONE
researchProduct

Endovascular stentectomy using the snare over stent-retriever (SOS) technique: An experimental feasibility study

2017

PLoS one 12(5), e0178197 (2017). doi:10.1371/journal.pone.0178197

GlycerolSwinePhysiologylcsh:Medicine030218 nuclear medicine & medical imaging0302 clinical medicinePig ModelsBlood FlowMedicine and Health SciencesMedicinelcsh:ScienceData flow modelClinical scenarioMammalsMultidisciplinaryExperimental DesignEndovascular ProceduresVasospasmAnimal ModelsProsthesis FailureBody FluidsPhysical sciencesChemistryBloodExperimental Organism SystemsResearch DesignVertebratesFemaleStentsRadiologyAnatomyResearch ArticleBiotechnologymedicine.medical_specialtyCathetersSurgical and Invasive Medical ProceduresMonomers (Chemistry)Research and Analysis Methods03 medical and health sciencesAnimal modelText miningIn vivoBlood vessel prosthesisAnimalsHumansPolymer chemistryStent retrieverbusiness.industrylcsh:ROrganismsBiology and Life Sciencesmedicine.diseaseBlood Vessel ProsthesisDisease Models AnimalStent ImplantationAmniotesFeasibility StudiesMedical Devices and Equipmentlcsh:Qbusiness030217 neurology & neurosurgeryPLOS ONE
researchProduct

Smoking cessation opportunities in severe mental illness (tobacco intensive motivational and estimate risk — TIMER—): study protocol for a randomized…

2019

There is an increased risk of premature death in people with severe mental illness (SMI). Respiratory disorders and cardiovascular disease are leading causes of increased mortality rates in these patients, and tobacco consumption remains the most preventable risk factor involved. Developing new tools to motivate patients towards cessation of smoking is a high priority. Information on the motivational value of giving the lung age and prevention opportunities is unknown in this high-risk population. In the context of community care, screening and early detection of lung damage could potentially be used, together with mobile technology, in order to produce a prevention message, which may provi…

Health Knowledge Attitudes PracticeBipolar DisorderTime FactorsWireless technology:Phenomena and Processes::Physical Phenomena::Time::Time Factors [Medical Subject Headings]medicine.medical_treatmentHealth Behavior:Psychiatry and Psychology::Mental Disorders::Mood Disorders::Affective Disorders Psychotic::Bipolar Disorder [Medical Subject Headings]:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Tobacco Use::Smoking [Medical Subject Headings]Medicine (miscellaneous)EsquizofreniaSmoking PreventionSeverity of Illness Indexlaw.invention:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Tecnología inalámbricaStudy ProtocolPulmonary Disease Chronic Obstructive0302 clinical medicineRandomized controlled triallawEnfermedad pulmonar obstructiva crónicaMulticenter Studies as TopicPharmacology (medical)Prospective Studies030212 general & internal medicineProspective cohort studyLungRandomized Controlled Trials as Topic:Psychiatry and Psychology::Behavioral Disciplines and Activities::Schizophrenic Psychology [Medical Subject Headings]lcsh:R5-920:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]COPDeducation.field_of_study:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Health Behavior [Medical Subject Headings]Chronic obstructive pulmonary diseaseSmokingTrastorno bipolar:Anthropology Education Sociology and Social Phenomena::Education::Education Nonprofessional::Health Education::Patient Education as Topic [Medical Subject Headings]Cese del uso del tabacoTobacco cessation:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Patient Acuity::Severity of Illness Index [Medical Subject Headings]Treatment OutcomeScreeningSchizophrenic Psychologylcsh:Medicine (General)medicine.medical_specialty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings]Bipolar disorderPopulationContext (language use)03 medical and health sciencesPatient Education as Topic:Information Science::Information Science::Communications Media::Telecommunications::Telephone::Cellular Phone::Text Messaging [Medical Subject Headings]Mobile technologySeverity of illness:Psychiatry and Psychology::Mental Disorders::Schizophrenia and Disorders with Psychotic Features::Schizophrenia [Medical Subject Headings]medicine:Diseases::Respiratory Tract Diseases::Lung Diseases::Lung Diseases Obstructive::Pulmonary Disease Chronic Obstructive [Medical Subject Headings]HumansRisk factoreducation:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]:Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]MotivationText Messagingbusiness.industry:Anatomy::Respiratory System::Lung [Medical Subject Headings]:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Motivation [Medical Subject Headings]medicine.disease:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Multicenter Studies as Topic [Medical Subject Headings]SpainEmergency medicineSchizophreniaSmoking cessation:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Tobacco Use::Tobacco Use Cessation::Smoking Cessation [Medical Subject Headings]Smoking Cessationbusiness030217 neurology & neurosurgeryTrials
researchProduct

Effectiveness of a physical therapeutic exercise programme for caregivers of dependent patients: a pragmatic randomised controlled trial from Spanish…

2020

Producción Científica

Health Toxicology and MutagenesisCalidad de vidaCost-Benefit Analysislcsh:Medicinefemale caregivers3213.11 Fisioterapialaw.invention:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]0302 clinical medicineRandomized controlled triallawSalud pública030212 general & internal medicineFisioterapiaFamily caregiverspublic healthCuidadores:Health Care::Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [Medical Subject Headings]Exercise TherapyTreatment OutcomeCaregiversAnxietyFemalePublic Healthmedicine.symptom:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Physical Therapy Modalities::Exercise Therapy [Medical Subject Headings]Developed countryQuality of lifemedicine.medical_specialty:Health Care::Health Care Facilities Manpower and Services::Health Personnel::Caregivers [Medical Subject Headings]Exercise therapyArticle03 medical and health sciencesprimary careQuality of life (healthcare):Health Care::Health Care Economics and Organizations::Economics::Costs and Cost Analysis::Cost-Benefit Analysis [Medical Subject Headings]Atención primaria de salud32 Ciencias MédicasmedicineHumansWomen:Humanities::Humanities::Philosophy::Life::Quality of Life [Medical Subject Headings]physiotherapyPrimary care (Medicine):Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]:Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]therapeutic exercisePrimary Health Carebusiness.industryPublic healthlcsh:RPublic Health Environmental and Occupational HealthMental healthClinical trial:Check Tags::Female [Medical Subject Headings]quality of lifeSpainDependenciaPhysical therapybusinessCuidador familiarPhysical therapy030217 neurology & neurosurgery
researchProduct