Search results for "MANF"
showing 10 items of 11 documents
La vegetazione del litorale di Manfria, presso Gela (Sicilia), area soggetta a vincolo archeologico.
2000
The results of a phytosociological investigation about a coastal area of S. Sicily, close to Gela, are presented. The coexistence of several lithological substrata, as well as the particular climatic conditions of this area, gives rise to a noteworthy floristic and vegetational biodiversity. As matter of fact, a set of N. African species are here localized, taking part to peculiar vegetation types, sometimes exclusive of this sicilian coast-stretch. The observed plant communities are represented by psammophilous associations of Cakiletea maritimae, Ammophiletea and Malcolmietalia, salt-marsh vegetation of Sarcocornietea and Phragmito-Magnocericetea, halophilous rupicolous shrublands of Crit…
Il tessuto del mare. Manfredonia. Blue in green
2010
Alcuni cliché descrittivi, adoperati per la città contemporanea, sembrano potersi usare ovunque sia necessario tratteggiare caratteri urbani privi di qualunque specificità. Fra le valutazioni stereotipate prevale quella della città-caos, soprattutto quando la struttura urbana si presenta come unica nebulosa antropica in cui è impossibile identificare i diversi nuclei urbani che la compongono. Tale condizione sembra essere del tutto estranea alla realtà di Manfredonia che è nettamente distinta dagli altri centri che insistono sull'ampia pianura del Gargano. Il saggio si occupa criticamente degli esiti del workshop svolto a Manfredonia dal 9 al 13 settembre 2009 dal titolo "Il Golfo di Manfre…
An evolutionary perspective on the role of mesencephalic astrocyte-derived neurotrophic factor (MANF): At the crossroads of poriferan innate immune a…
2017
The mesencephalic astrocyte-derived neurotrophic factor (MANF) belongs to a recently discovered family of neurotrophic factors. MANF can be secreted but is generally resident within the endoplasmic reticulum (ER) in neuronal and non-neuronal cells, where it is involved in the ER stress response with pro-survival effects. Here we report the discovery of the MANF homolog SDMANF in the sponge Suberites domuncula. The basal positioning of sponges (phylum Porifera) in the animal tree of life offers a unique vantage point on the early evolution of the metazoan-specific genetic toolkit and molecular pathways. Since sponges lack a conventional nervous system, SDMANF presents an enticing opportunity…
L’ILLECITO ANTITRUST DOPO LA DIRETTIVA 2014/104/UE
2020
Tradizionalmente, tanto a livello nazionale quanto a livello comunitario, la tutela della concorrenza si è caratterizzata per l’impiego di strumenti di enforcement pubblicistico. Dopo un lungo iter, il 26 novembre 2014 è stata pubblicata la direttiva del Parlamento Europeo e del Consiglio UE 2014/104 relativa a determinate norme che regolano le azioni per il risarcimento del danno ai sensi del diritto nazionale per violazioni delle disposizioni del diritto della concorrenza degli Stati membri e dell'Unione europea. In Italia il recepimento della Direttiva è avvenuto il 19 gennaio 2017 con il d.lgs. n. 3/2017. Sebbene la normativa in parola intervenga a colmare il vuoto creato dall’assenza, …
Architectural Utopias as Methods for Experimenting with the (Im)Possible
2020
The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor
2021
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-stress-regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and non-neuronal damage. Although initially characterized as a secreted neurotrophic factor for midbrain dopamine neurons, MANF has recently gained more interest for its intracellular role in regulating the ER homeostasis, including serving as a cofactor of the chaperone glucose-regulated protein 78 (GRP78). We aimed for a better understanding of the neuroprotective mechanisms of MANF. Here we show for the first time that MANF promotes the survival of …
Costruire la regalità. Feste teatrali e cerimonie con musica a Napoli tra Giuseppe e Gioacchino (1806-1815)
2016
The article examines the occasional genres flourished during the French domination in Naples (1806-1815). The new Napoleonic dinasty needed to obtain public consent, and so adopted old and new strategies of communication. In fact, the study of many different sources (librettos, scores, newspapers) indicates a fascinating coexistence of tradition and innovation. The period taken into consideration still offers many examples of traditional cantatas performed in theatres and aristocratic palaces. Together with these conventional pièces, though, it is possible to observe original and innovative creations, such as choreographic actions, prose comedies with incidental music and, above all, large …
Il progetto ECONET-COHAST: Strategie per la conservazione degli habitat costieri di Torre Manfria (Sicilia merid.)
2007
The coexistence of several lithological substrata, together with particular geomorphologic and climatic features, are determining the exceptional floristic and faunistic interest of the coastal trait between Gela and Torre Manfria. In order to preserve and enhance coastal habitats, such area has been chosen as case-study in the Interreg project ECONET-COHAST, which involves six partners from four EU countries (Cyprus, Greece, Italy and Malta). In this paper, the main features of the area are described and the approach followed in order to implement conservation strategies accounting for the local development exigencies is illustrated. © Società Italiana di Scienza della Vegetazione.