Search results for "MAb"

An FPGA aligner for short read mapping

2012

The rapid growth of short read datasets poses a new challenge to the mapping of short reads to a reference genome in terms of sensitivity and execution speed. In this work, we present a parallel architecture for short read mapping utilizing field programmable gate array (FPGA)-based hardware. The computation intensive semi-global alignment and the hash table lookup operations are mapped onto an FPGA. The proposed Align Core is implemented with a parallel block structure to gain computational efficiency. We present a new parallel block-wise alignment structure to approximate the conventional dynamic programming algorithm. The performance of our FPGA aligner is compared to the GASSST and BWA …

A hybrid short read mapping accelerator

2013

Background The rapid growth of short read datasets poses a new challenge to the short read mapping problem in terms of sensitivity and execution speed. Existing methods often use a restrictive error model for computing the alignments to improve speed, whereas more flexible error models are generally too slow for large-scale applications. A number of short read mapping software tools have been proposed. However, designs based on hardware are relatively rare. Field programmable gate arrays (FPGAs) have been successfully used in a number of specific application areas, such as the DSP and communications domains due to their outstanding parallel data processing capabilities, making them a compet…

Validación del registro deformable de imágenes en radioterapia adaptativa

2017

En los últimos años, una de las áreas de mayor interés en la radioterapia ha sido la radioterapia adaptativa (ART), siendo la forma más versátil y eficiente de realizarla utilizar el registro de imágenes deformable (DIR). Este se basa en crear un campo de deformación vectorial entre dos imágenes, que permite relacionar los vóxels de una imagen con la otra. Una de las grandes dificultades para implementar la ART en los centros hospitalarios es la dificultad para validar si el algoritmo de DIR relaciona correctamente las dos imágenes que queremos registrar deformablemente. En esta tesis se pretende validar el algoritmo hibrido del sistema de planificación computarizada (TPS) RayStation (v.4.0…

CLINICAL CHARACTERISTICS AND PLASMA LIPIDS IN SUBJECTS WITH FAMILIAL COMBINED HYPOLIPIDEMIA: A POOLED ANALYSIS

2013

Background. Angiopoietin-like 3 (ANGPTL3) regulates lipoprotein metabolism by modulating extracellular lipases. Loss-of function mutations in ANGPTL3 gene cause familial combined hypolipidemia (FHBL2). The mode of inheritance and hepatic and vascular consequences of FHBL2 have not been fully elucidated. To get further insights on these aspects, we re-evaluated the clinical and the biochemical characteristics of all reported cases of FHBL2. Methods and Results. One hundred fteen FHBL2 individuals carrying 13 different mutations in the ANGPTL3 gene (14 homozygotes, 8 compound heterozygotes and 93 heterozygotes) and 402 controls were considered. Carriers of 2 mutant alleles had undetectable pl…

Makro- un mikroelementu sastopamības variācijas mellenēs Vaccinium Myrtillus L.) un augsnē

2020

Darbā tika analizēts dzelzs, cinka, vara, kālija un fosfātjonu saturs mellenēs (Vaccinium myrtillus L.), krūmmellenēs (Vaccinium corymbosum) un to augsnē. Melleņu un augsnes paraugi tika ievākti meža teritorijā, kur tika mēslots ar vieglajiem koksnes pelniem. Krūmmelleņu ogu un augsnes paraugi tika ievākti privātmājas teritorijā, kur netika izmantots nekāds mēslojums. Veicot sauso mineralizāciju, ar liesmas atomabsorbciometrijas metodi noteikts dzelzs, cinka un vara saturs, fotometriski tika noteikts fosfātjonu saturs un ar liesmas fotometriju tika noteikts kālija saturs. Iegūtie rezultāti tika apstrādāti, izvērtēts noteikto elementu saturs mellenēs un krūmmellenēs, kā arī iegūtie rezultāti…

Augsnes piesārņojuma ar smagajiem metāliskajiem elementiem izvērtējums dzelzceļa apkārtnē

2018

Augsnes piesārņojuma ar smagajiem metāliskajiem elementiem izvērtējums dzelzceļa apkārtnē. Jansons Ā., zinātniskais vadītājs Dr. chem., doc. Osīte A. Bakalaura darbs, 52 lappuses, 21 attēls, 7 tabulas, 25 literatūras avoti, 5 pielikumi. Latviešu valodā. Darba ietvaros ir veikta smago metālisko elementu – dzelzs, mangāna, vara, cinka, niķeļa un svina jonu kvantitatīvā analīze augsnes paraugos, kas ievākti Torņakalna, Jāņavārtu, Dārziņu un Kūdras dzelzceļa staciju apkārtnē – blakus stacijai (vilcienu bremzēšanas ceļa sākumā) un atstatus no tās. Vispirms tika veikta ievākto augsnes paraugu sagatavošana mineralizācijai (žāvēšana, homogenizēšana, sijāšana). Augsnes paraugu matricas sagraušana ti…

Metālisko elementu saturs augsnē Liepājas Ziemeļu Fortu teritorijā

2019

Metālisko elementu saturs augsnē Liepājas Ziemeļu fortu teritorijā. Butkus D., darba vadītāja Mg. chem., lektore Balcerbule Z. Bakalaura darbs, 45 lappuses, 21 attēls, 18 tabulas, 32 literatūras avoti, 4 pielikumi. Latviešu valodā. Darbā ir veikta metālisko elementu analīze Ziemeļu fortu teritorijā ņemtajos augsnes paraugos. Augsnes izvilkumi gatavoti HNO3 šķīdumos, veikta arī mineralizācija ar mikroviļņu enerģiju. Elementu koncentrācijas tika noteiktas ar liesmas atomabsorbciometrijas un ICP – MS metodēm. Iegūtie rezultāti tika salīdzināti ar LR MK augsnes un grunts kvalitātes normatīviem un literatūrā pieejamiem datiem.

Osteonecrosis of the jaw after long-term oral bisphosphonates, followed by short-term denosumab treatment for osteoporosis: a case report

2014

Bisphosphonates and denosumab are antiresoptive agents and are mainly used for management of metastatic bone cancer, osteoporosis and other diseases. Bisphosphonates (BP) can reduce skeletal related events (SRE) by 30–50%1; denosumab (D) has been found even more effective than BP2. BP and D have been both associated to osteonecrosis of the jaw (ONJ). We report a case of an osteoporotic woman (62 yrs), complaining maxillary intense pain after a recent tooth molar extraction, observed in July 2013 at our centre. She mentioned previous treatments with monthly ibandronate (Bonviva ® 150 mg) per os (from January 2003 to April 2010), risedronate (35 mg weekly, from May 2010 to May 2012) and two a…

Analisi dei fattori che rendono le cellule di adenocarcinoma colorettale resistenti o suscettibili all’azione di chemioterapici

2015

The HERBA Study: A Retrospective Multi-Institutional Italian Study on Patients With Brain Metastases From HER2-Positive Breast Cancer

2019

There is no sufficient evidence to establish a standard of care for patients with brain metastases (BM) from HER2Data of 154 patients were retrospectively collected at 14 Italian institutions through a specifically designed database.Median overall survival (OS) was 24.5 months. Patients receiving surgery/stereotactic radiosurgery experienced longer OS compared to those receiving whole-brain radiotherapy or no treatment (33.5 vs. 11.4 months; hazard ratio = 0.34; 95% confidence interval, 0.22-0.52; P .001). Interestingly, whole-brain radiotherapy did not improve OS compared to no treatment (11.4 vs. 9.8 months; hazard ratio = 0.99; 95% confidence interval, 0.62-1.62; P = .99). HER2-targeted …