Search results for "MAb"

On the solutions to 1-Laplacian equation with L1 data

2009

AbstractIn the present paper we study the behaviour, as p goes to 1, of the renormalized solutions to the problems(0.1){−div(|∇up|p−2∇up)=finΩ,up=0on∂Ω, where p>1, Ω is a bounded open set of RN (N⩾2) with Lipschitz boundary and f belongs to L1(Ω). We prove that these renormalized solutions pointwise converge, up to “subsequences,” to a function u. With a suitable definition of solution we also prove that u is a solution to a “limit problem.” Moreover we analyze the situation occurring when more regular data f are considered.

Real-Time Implementation of Signal Processing Techniques for Disturbances Detection

2019

The real-time analysis of power quality (PQ) disturbances and islanding detection for distributed generation (DG) system using signal processing algorithms are still at a premature stage. Quick and reliable detection of islanding and PQ disturbances needs renewed focus. This paper is concentrated on the implementation of advanced signal processing techniques in field-programmable gate array (FPGA) to identify PQ and islanding events in real time. The proposed scheme is based on orthogonal empirical mode decomposition (OEMD) implemented in FPGA. This technique does not suffer from the loss of signal characteristics with successive decomposition levels. The performance of said technique is de…

A real-time non-intrusive FPGA-based drowsiness detection system

2011

Automotive has gained several benefits from the Ambient Intelligent researches involving the deployment of sensors and hardware devices into an intelligent environment surrounding people, meeting users’ requirements and anticipating their needs. One of the main topics in automotive is to anticipate driver needs and safety, in terms of preventing critical and dangerous events. Considering the high number of caused accidents, one of the most relevant dangerous events affecting driver and passengers safety is driver’s drowsiness and hypovigilance. This paper presents a low-intrusive, real-time driver’s drowsiness detection system for common vehicles. The proposed system exploits the ‘‘bright p…

Adalimumab Induction for Crohn’s Disease

2006

Teprotumumab for the treatment of active thyroid eye disease

2020

Abstract Background Thyroid eye disease is a debilitating, disfiguring, and potentially blinding periocular condition for which no Food and Drug Administration–approved medical therapy is available...

Drug-related cardiotoxicity for the treatment of haematological malignancies in elderly.

2010

Several publications have focused on the cardiotoxicity of specific classes of haematological therapeutic agents such as antracyclines and cyclofosfamide. Cardiotoxicity of cancer chemotherapeutics is a problem for patients of all ages, but it increases with age. Toxicity can also be developed months after the last chemotherapy dose, and late reactions can be seen years later when they present new-onset cardiomyopathy. No data are available about the cardiotoxicity of non-chemotherapy agents currently used as preferred therapy for haematological malignancy in elderly. In this review we have provided a summary of the cardiovascular toxic effects produced by different drugs and therapeutic ag…

Changing Trends in Drug Prescription and Causes of Treatment Discontinuation of First Biologic Over Ten Years in Psoriasis in the Spanish Biobadaderm…

2020

Background and objectives: Current psoriasis guidelines do not usually include recommendations about first line classical or biologic treatment. The objectives of this study were: to describe shifts in the prescription of the first biological treatment, and to compare treatment withdrawal and rates of adverse events over ten years. Material and methods: Biobadaderm registry was analyzed to describe: first biological prescription in bio-naive patients, adverse events rate and reasons for drug withdrawal comparing three periods of time (2008-2010, 2011-2014, 2015-2018). Results: Anti-TNF drugs were the most prescribed biological drug from 2008 to 2010. Ustekinumab has become the most prescrib…

Pembrolizumab: a new Drug That Can Induce Exacerbations of Psoriasis.

2015

A mild form of rituximab-associated lung injury in two adolescents treated for nephrotic syndrome: Table 1

2015

Rituximab is used as a steroid/calcineurin inhibitor-saving agent in patients with nephrotic syndrome. Safety is a crucial issue for justifying widespread use of the drug in this clinical setting. Rituximab-associated lung injury (RALI) is a severe and potentially life-threatening complication in oncohaematological and rheumatological patients, while it has only been anecdotally reported in association with idiopathic nephrotic syndrome (2 cases described, 1 with fatal outcome). We describe a benign form of RALI occurring in two adolescents treated with rituximab (single pulse of 375 mg/m2) for nephrotic syndrome. Before treatment, the patients were in good clinical condition while receivin…

SP0027 Biosimilars: Potential Clinical Differences and European Regulatory Aspects

2014

Although successful drugs, the use of anti-TNFs is limited by their high cost, and in the present climate of economic difficulty, there is pressure to find alternatives that reproduce their effects at a lower price. Due to their large molecular size and structural complexity, anti-TNFs are impossible to duplicate, unlike smaller, chemically-generated compounds, which can be copied. However, unlike generics, biosimilars are similar rather than identical to the original drugs. Determining the level of similarity that guarantees a comparable efficacy and safety represents a new test for the pharmacological market. Biosimilars of smaller biological molecules, such as somatotropin, EPO and GCSF …