Search results for "MAb"
showing 10 items of 1716 documents
Development of readout electronics for the ATLAS tile calorimeter at the HL-LHC
2017
El Gran Colisionador de Hadrones (LHC) es uno de los experimentos más grandes en el mundo. El LHC ha sido diseñado para explorar las fronteras de la física, descubriendo el bosón de Higgs en el año 2012 a través de una colaboración compuesta por más de 7,000 científicos e ingenieros. Durante el año 2026 el acelerador LHC sufrirá una actualización que dará paso al nuevo acelerador High Luminosity LHC (HL-LHC). El nuevo acelerador aumentará la luminosidad instantánea en un factor 5 comparado con el actual LHC y hasta un factor 10 la lumninosidad integrada. El diseño del HL-LHC y la consecuente actualización de los experimentos instalados en él, representa un desafío tecnológico excepcional. E…
The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persisten…
2005
Background: Patients with severe persistent asthma who are inadequately controlled despite treatment according to current asthma management guidelines have a significant unmet medical need. Such patients are at high risk of serious exacerbations and asthma-related mortality. Methods: Here, we pooled data from seven studies to determine the effect of omalizumab, an anti-immunoglobulin E (IgE) monoclonal antibody, on asthma exacerbations in patients with severe persistent asthma. Omalizumab was added to current asthma therapy and compared with placebo (in five double-blind studies) or with current asthma therapy alone (in two open-label studies). The studies included 4308 patients (2511 tre…
A Look at the Future Hemophilia A Treatment
2018
The current treatment of patients with hemophilia A is safer and more effective than the previous one. Prophylactic substitution involves repeated intravenous administration of plasma-derived factor VIII or recombinant factor VIII products, with inconveniences and possible adverse effects. The occurrence of inhibitors requires the administration of activated prothrombin complex concentrate or activated factor VII - an expensive treatment. The immune tolerance induction is the ideal treatment for patients with high titres of inhibitors - the only potential way to eliminate inhibitors and very expensive. For these reasons, the medical world is interested in the advances that scientific resear…
An AER handshake-less modular infrastructure PCB with x8 2.5Gbps LVDS serial links
2014
Nowadays spike-based brain processing emulation is taking off. Several EU and others worldwide projects are demonstrating this, like SpiNNaker, BrainScaleS, FACETS, or NeuroGrid. The larger the brain process emulation on silicon is, the higher the communication performance of the hosting platforms has to be. Many times the bottleneck of these system implementations is not on the performance inside a chip or a board, but in the communication between boards. This paper describes a novel modular Address-Event-Representation (AER) FPGA-based (Spartan6) infrastructure PCB (the AER-Node board) with 2.5Gbps LVDS high speed serial links over SATA cables that offers a peak performance of 32-bit 62.5…
Insight into the Evolving Role of PCSK9
2022
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells. This serine protease plays a pivotal role in the reduction of the number of low-density lipoprotein receptors (LDLRs) on the surface of hepatocytes, which leads to an increase in the level of cholesterol in the blood. This mechanism and the fact that gain of function (GOF) mutations in PCSK9 are responsible for causing familial hypercholesterolemia whereas loss-of-function (LOF) mutations are associated with hypocholesterolemia, prompted the invention of drugs that block PCSK9 action. The high efficiency of PCSK9 inhibitors (…
Differential effects of anti-TNF-α and anti-IL-12/23 agents on human leukocyte–endothelial cell interactions
2015
AbstractEnhanced leukocyte recruitment is an inflammatory process that occurs during early phases of the vascular dysfunction that characterises atherosclerosis. We evaluated the impact of anti-TNF-α (adalimumab, infliximab and etanercept) and anti-IL-12/23 (ustekinumab) on interactions between human leukocytes and endothelial cells in a flow chamber that reproduced in vivo conditions. Clinical concentrations of anti-TNF-α were evaluated on the leukocyte recruitment induced by a variety of endothelial (TNF-α, interleukin-1β, lymphotoxin-α and angiotensin-II) and leukocyte (PAF, IL-12 and IL-23) stimuli related to inflammation and atherosclerosis. Treatment with anti-TNF-α, even before or af…
Conformable eddy current array delivery
2016
The external surface of stainless steel containers used for the interim storage of nuclear material may be subject to Atmospherically Induced Stress Corrosion Cracking (AISCC). The inspection of such containers poses a significant challenge due to the large quantities involved; therefore, automating the inspection process is of considerable interest. This paper reports upon a proof-of-concept project concerning the automated NDT of a set of test containers containing artificially generated AISCCs. An Eddy current array probe with a conformable padded surface from Eddyfi was used as the NDT sensor and end effector on a KUKA KR5 arc HW robot. A kinematically valid cylindrical raster scan path…
Improving Formability in SPIF Processes through High Speed Rotating Tool: Experimental and Numerical Analysis
2013
Single-point incremental forming (SPIF) is a quite new sheet-forming process which offers the possibility to deform complex parts without dedicated dies using a single-point tool and a standard three-axis CNC machine. Although the process mechanics enables higher strains with respect to traditional sheet-forming processes, research has been focused on further increasing the maximum forming angle. In the paper, a new approach is used to enhance the material formability through a localized sheet heating as a consequence of the friction work caused by high speed rotating tool. Numerical simulation was utilized to relate the effect of temperature with the main field variables distribution in th…
Experimental analysis with FPGA controller-based of MC PWM techniques for three-phase five level cascaded H-bridge for PV applications
2016
The FPGA represents a valid solution for the design of control systems for inverters adopted in the field of PV systems because of their high flexibility of use. This paper presents an experimental analysis of the MC SPWM techniques for a three-phase, five-level, cascaded H-Bridge inverter with FPGA controller-based. Several control algorithms are implemented by means of the VHDL programming language and the output voltage waveforms obtained from the main PWM techniques are compared in terms of THD%. Simulation and experimental results are analysed, compared and discussed.
An Intelligent Tool to Predict Fracture in Sheet Metal Forming Operations
2007
One of the main issues in sheet metal forming operations design is the determination of formability limits in order to prevent necking and fracture. In fact, the ability to predict fracture represents a powerful tool to improve the production quality in mechanical industry. Many researchers investigated the problem here addressed, mainly studying forming limit diagrams (FLD) or developing fracture criteria which are able to foresee fracture defects for different processes. In this paper, the author present some early results of a research project focused on the application of artificial intelligence (AI) for ductile fracture prediction in sheet metal forming operations. The main advantage o…