Search results for "MAb"
showing 10 items of 1716 documents
Language for International Communication: Linking Interdisciplinary Perspectives (2nd international symposium)
2014
This collection contains papers delivered at the 2nd international symposium "Language for International Communication: Linking Interdisciplinary Perspectives" held at the University of Latvia, Latvia, on 23-24 May 2013.
Anti-PCSK9 treatment: Is ultra-low LDL always good?
2018
Anti-pcsk9 (proprotein convertase subtilisin kexin 9) monoclonal antibodies (Mab) are novel, potent lipid-lowering drugs. They demonstrated to improve the lipid profile in high cardiovascular risk patients. Anti-pcsk9 Mab inhibit the targeted LDL-receptor degradation induced by pcsk9 protein and are able to reduce LDL cholesterol (LDL-C) levels on top of conventional lipid-lowering therapy.Though these drugs proved to be very safe in the short term, little is known about the possible long term effects, due to the short period of their marketing. The genetic low-cholesterol syndromes (LCS) represent the natural models of the lipid-lowering anti-PCSK9 therapy, and a valuable opportunity to pr…
Intravitreal injection of bevacizumab induces inflammatory alterations in a uveitis experimental model.
2010
PurposeBevacizumab is currently used as an intravitreal agent in the treatment of inflammatory-associated eye diseases. The aim of the current study is to explore the effects of the intravitreal injection of bevacizumab on aqueous humour cytokines and chemokines in an experimental uveitis model.MethodsEndotoxin-induced uveitis was induced in rats by footpad injections. Bevacizumab was administered by intravitreal injection (75 μg in 3–μL samples) and different chemokine and cytokine proteins were quantified in aqueous humor.ResultsIntravitreal administration of bevacizumab led to a several-fold increase of RANTES, MCP-1, and IFN-γ concentrations in aqueous humor of endotoxin-treated rats.Co…
Combination therapy of recalcitrant severe psoriasis with psoriatic arthritis, diabetes nephropathy, and liver cirrhosis
2021
Objective Treatment of recalcitrant moderate-to-severe psoriasis can be challenging. Combination therapy of biologics and immunosuppressive agents can be a new strategy for treating therapy-resistant cases with comorbidities, where many systemic medications are contraindicated. Case presentation We report a case of a 62-year-old diabetic man with a 30-year history of severe plaque psoriasis and psoriatic arthritis with cirrhosis and diabetic nephropathy that was treated successfully in combination with apremilast and etanercept after multiple previous unsuccessful treatment attempts. Conclusion There are no data supporting the combination of apremilast and etanercept in the management of re…
Performance and Implementation Modeling of Gated Linear Networks on FPGA for Lossless Image Compression
2020
Over recent years, imaging systems have seen explosive increase in resolution. These trends present a challenge for resource-constrained embedded imaging devices. Efficient image compression is essential to reduce bandwidth consumption and to increase the capability of on-board storage. Especially, for imaging systems where information loss is not allowed, for example, in medical, military and remote sensing imaging systems. This paper explores the use of Gated Linear Networks (GLNs) for development of embedded lossless compression systems. GLNs have proved themselves via PAQ archiver series, that have been ranked among the top across several lossless compression benchmarks. We propose an a…
FPGA Implementation Of Diffusive Realization For A Distributed Control Operator
2010
International audience; We focus on the question of real-time computation for optimal distributed filtering or control applicable to MEMS Arrays. We present an algorithm for the realization of a linear operator solution to a functional equation through its application to a Lyapunov operatorial equation associated to the heat equation in one dimension. It is based on the diffusive realization, and turns to be well suited for fined grained parallel computer architecture as Field Programmable Gate Arrays (FPGA). An effective FPGA implementation has been successfully carried out. Here, we report the main implementation steps and the final measured performances.
Hepatitis C virus - associated B cell non-Hodgkin's lymphoma.
2016
The hepatitis C virus (HCV) infected patients are prone to develop bone marrow or various tissue infiltrates with monoclonal B cells, monoclonal B lymphocytosis or different types of B cell non-Hodgkin's lymphoma (BCNHL), of which the most common are splenic marginal zone BCNHL, diffuse large BCNHL and follicular lymphoma. The association between chronic HCV infection and non Hodgkin's lymphoma has been observed especially in areas with high prevalence of this viral infection. Outside the limitations of some studies that have been conducted, there are also geographic, environmental, and genetic factors that contribute to the epidemiological differences. Various microenvironmental signals, s…
Tumor Regression in Cancer Patients by Very Low Doses of a T Cell–Engaging Antibody
2008
Previous attempts have shown the potential of T cells in immunotherapy of cancer. Here, we report on the clinical activity of a bispecific antibody construct called blinatumomab, which has the potential to engage all cytotoxic T cells in patients for lysis of cancer cells. Doses as low as 0.005 milligrams per square meter per day in non–Hodgkin's lymphoma patients led to an elimination of target cells in blood. Partial and complete tumor regressions were first observed at a dose level of 0.015 milligrams, and all seven patients treated at a dose level of 0.06 milligrams experienced a tumor regression. Blinatumomab also led to clearance of tumor cells from bone marrow and liver. T cell–engag…
New Potential Therapeutic Approach for the Treatment of B-Cell Malignancies Using Chlorambucil/Hydroxychloroquine-Loaded Anti-CD20 Nanoparticles
2013
Current B-cell disorder treatments take advantage of dose-intensive chemotherapy regimens and immunotherapy via use of monoclonal antibodies. Unfortunately, they may lead to insufficient tumor distribution of therapeutic agents, and often cause adverse effects on patients. In this contribution, we propose a novel therapeutic approach in which relatively high doses of Hydroxychloroquine and Chlorambucil were loaded into biodegradable nanoparticles coated with an anti-CD20 antibody. We demonstrate their ability to effectively target and internalize in tumor B-cells. Moreover, these nanoparticles were able to kill not only p53 mutated/deleted lymphoma cell lines expressing a low amount of CD20…
Essays on the Spanish REIT market
2021
Los Real Estate Investment Trust (REIT), equivalentes a la figura española de las Sociedades Anónimas Cotizadas de Inversión en el Mercado Inmobiliario (SOCIMI), son instrumentos de inversión colectiva cuyo propósito es la tenencia directa o indirecta de activos inmobiliarios para el alquiler. El incremento de las salidas a bolsa de estos vehículos de inversión en Europa en los últimos años ha permitido el estudio de estos mercados cuya importancia y tamaño ha crecido notablemente. En España, la primera SOCIMI se incorporó al mercado a finales de 2013 y desde ese momento se ha producido un rápido crecimiento en el número y tamaño de estas sociedades. A lo largo de esta Tesis Doctoral se ha …