Search results for "MCD"

Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results…

2009

Background Cognitive impairment is a common symptom of multiple sclerosis (MS), but the association between cognitive impairment and magnetic resonance imaging (MRI) disease measures in patients with relapsing–remitting (RR) MS is unclear. Objectives To study the prevalence of cognitive impairment and its relation with MRI disease measures in mildly disabled patients with RRMS. Methods Patients aged 18–50 years with RRMS (McDonald criteria) and an Expanded Disability Status Scale (EDSS) score ≤4.0, who were enrolled in the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study, underwent baseline standardized MRI complete neurological examination and neuropsychological testing. Results…

Effects of immunomodulatory treatment with subcutaneous interferon beta-1a on cognitive decline in mildly disabled patients with relapsing-remitting …

2010

The objective of this study was to assess the effects of subcutaneous (sc) interferon beta-1a (IFNβ-1a) on cognition in mildly disabled patients with relapsing—remitting multiple sclerosis (RRMS). Patients aged 18—50 years with RRMS (McDonald criteria; Expanded Disability Status Scale score ≤4.0) were assigned IFNβ therapy at the physician’s discretion and underwent standardized magnetic resonance imaging, neurological examination and neuropsychological testing at the baseline and regular intervals for up to three years. This analysis included 459 patients who received sc IFNβ-1a (44 mcg: n = 236; 22 mcg: n = 223; three-year follow up was available for 318 patients). The hazard ratio for c…

Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis.

2012

Nonalcoholic steatohepatitis (NASH) is associated with increased liver-related mortality. Disturbances in hepatic lipid homeostasis trigger oxidative stress and inflammation (ie, lipotoxicity), leading to the progression of NASH. This study aimed at identifying whether silibinin may influence the molecular events of lipotoxicity in a mouse model of NASH. Eight-week-old db/db mice were fed a methionine-choline deficient (MCD) diet for 4 weeks and treated daily with silibinin (20 mg/kg intraperitoneally) or vehicle. Liver expression and enzyme activity of stearoyl-CoA desaturase-1 and acyl-CoA oxidase, and expression of liver fatty acid-binding protein were assessed. Hepatic levels of reactiv…

Al driven peculiarities of local coordination and magnetic properties in single phase Alx CrFeCoNi high entropy alloys

2021

The authors thank the Helmholtz-Zentrum Berlin for the provision of access to synchrotron radiation facilities and allocation of synchrotron radiation at the PM2-VEKMAG, BAMline, and UE46_PGM-1 beamlines of BESSY II at HZB as well as measurement time for magnetometry at HZB CoreLab for Quantum Materials. A. S. acknowledges personal funding from CALIPSOplus project (the Grant Agreement no. 730872 from the EU Framework Programme for Research and Innovation HORIZON 2020). The financial support for the VEKMAG project and the PM2-VEKMAG beamline by the German Federal Ministry for Education and Research (Nos. BMBF 05K10PC2, 05K10WR1, 05K10KE1) and by HZB is cordially acknowledged by all co-author…

A survey on handling computationally expensive multiobjective optimization problems using surrogates: non-nature inspired methods

2015

Computationally expensive multiobjective optimization problems arise, e.g. in many engineering applications, where several conflicting objectives are to be optimized simultaneously while satisfying constraints. In many cases, the lack of explicit mathematical formulas of the objectives and constraints may necessitate conducting computationally expensive and time-consuming experiments and/or simulations. As another challenge, these problems may have either convex or nonconvex or even disconnected Pareto frontier consisting of Pareto optimal solutions. Because of the existence of many such solutions, typically, a decision maker is required to select the most preferred one. In order to deal wi…

Iekšējā komunikācija uzņēmumā "Premier Restaurants Latvia"

2021

Darba tēma – iekšējā komunikācija uzņēmumā “Premier Restaurants Latvia”. Darba mērķis – izpētīt iekšējo komunikāciju uzņēmumā “Premier Restaurants Latvia”. Teorētiskajā daļā aplūkots iekšējās komunikācijas jēdziens, apmācību kā procesa un apmācības koordinatoru lomas nozīmi, kādas metodes tie izmanto komunikācijā ar darbiniekiem, lai īstenotu iekšējās komunikācijas stratēģiskos mērķu, kurus ir definējis uzņēmuma birojs. Darba izstrādē izmantotā metodoloģija – elektroniskas aptaujas, fokusgrupas intervija, daļēji strukturētās intervijas, to transkripcija un tulkošana un kvalitatīvā kontentanalīze. Pētījuma rezultāti liecina, ka iekšējā komunikācija ir svarīga uzņēmuma “Premier Restaurants La…

Perception, Normativity and Action in Contemporary Philosophy of Mind and Cognitive Science

Working on the background of a view of mind as “in action”, as pragmatically shaped by its own dynamic interactions with the world, emerging from the achievements of contemporary philosophy of mind (from Searle to enactivism)and cognitive science (from Gibson to Goodale and Milner)I aim to propose a view of perception as a form of human activity of which we are responsible, and in which our “commitment” to truth and rationality can take place. Against some recent phenomenalist and antirepresentationalist views of perception I'll try to show that the action-oriented character of perception does not challenge its rational constraint to a right representation of the state of affairs which it i…

A Hybrid AHP Approach and GIS-Based Methods as Fundamental Tools in the SECAP’s Decision-Making Process

2023

Adapting to climate change and mitigating its impacts are the main challenges for cities today. One objective that the European Commission has set in recent decades is reducing climate change inaction, and several political actions have been implemented. Among these actions, the Covenant of Mayors led to the development and adoption of Sustainable Energy and Climate Action Plans (SECAPs) by many cities worldwide. A challenge that local authorities must face during the development of a SECAP is the identification of the policies to be included in the plan. This paper presents a case study to show the validity of using a hybrid analytic hierarchy process (AHP) approach and various geographic …

Is APOE ε4 associated with cognitive performance in early MS?

2020

ObjectiveTo assess the impact of APOE polymorphisms on cognitive performance in patients newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS).MethodsThis multicenter cohort study included 552 untreated patients recently diagnosed with CIS or RRMS according to the 2005 revised McDonald criteria. The single nucleotide polymorphisms rs429358 (ε4) and rs7412 (ε2) of the APOE haplotype were assessed by allelic discrimination assays. Cognitive performance was evaluated using the 3-second paced auditory serial addition test and the Multiple Sclerosis Inventory Cognition (MUSIC). Sum scores were calculated to approximate the overall cognitive performance and memo…

An academic performance indicator using flexible multi-criteria methods

2021

Composite indicators are a very useful tool for conveying summary information on the overall performance of institutions and facilitating decision-making. Increasingly, there is a demand for indicators that allow performance to be assessed after the implementation of a strategy. This has several difficulties, and in this paper, we address three of them: how to evaluate at different points in time, how to estimate the weighting of the criteria and how to normalize the data. Our proposal is based on multicriteria techniques, using a recent method, uwTOPSIS, and is applied to data collected from 2975 students enrolled in the first year of science and engineering at the Industrial University of…