Search results for "MCM"
showing 10 items of 92 documents
Antibody-Capped Mesoporous Nanoscopic Materials: Design of a Probe for the Selective Chromo-Fluorogenic Detection of Finasteride
2012
[EN] The synthesis of capped mesoporous silica nanoparticles (MSN) conjugated with an antibody (AB) as a gatekeeper has been carried out in order to obtain a delivery system able to release an entrapped cargo (dye) in the presence of a target molecule (antigen) to which the conjugated antibody binds selectively. In particular, MSN loaded with rhodamine B and functionalized on the external surface with a suitable derivative of N-(t-butyl)- 3-oxo-(5a,17b)-4-aza-androst-1-ene-17-carboxamide (finasteride) have been prepared (S1). The addition of polyclonal antibodies against finasteride induced capping of the pores due to the interaction with the anchored hapten-like finasteride derivative to g…
Water Sorption on Mesoporous Aluminosilicate MCM-41
1995
Characterization of the interaction of water with the highly ordered mesoporous solid MCM-41 (pore diameter ∼2.5 nm) is undertaken with the aid of several techniques (adsorption gravimetry, X-ray diffraction, Fourier transform infrared spectroscopy, and controlled rate-evolved gas analysis). The relatively complex water-MCM-41 interactions are characterized by a type V isotherm indicating an initial repulsive character followed by a capillary condensation step of the adsorbate. This highlights both hydrophobic and hydrophilic properties of this potential model mesoporous adsorbent.
Critical Appraisal of the Pore Structure of MCM-41
2006
Purely siliceous and aluminosilicate types of MCM-41 were synthesized and characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen sorption (NS) and size exclusion chromatography (SEC).
Comparison of different uncertainty techniques in urban stormwater quantity and quality modelling
2011
Abstract Urban drainage models are important tools used by both practitioners and scientists in the field of stormwater management. These models are often conceptual and usually require calibration using local datasets. The quantification of the uncertainty associated with the models is a must, although it is rarely practiced. The International Working Group on Data and Models, which works under the IWA/IAHR Joint Committee on Urban Drainage, has been working on the development of a framework for defining and assessing uncertainties in the field of urban drainage modelling. A part of that work is the assessment and comparison of different techniques generally used in the uncertainty assessm…
A Methodology for the Design of MOS Current-Mode Logic Circuits
2010
In this paper, a design methodology for the minimization of various performance metrics of MOS Current-Mode Logic (MCML) circuits is described. In particular, it allows to minimize the delay under a given power consumption, the power consumption under a given delay and the power-delay product. Design solutions can be evaluated graphically or by simple and effective automatic procedures implemented within the MATLAB environment. The methodology exploits the novel concepts of crossing-point current and crossing-point capacitance. A useful feature of it is that it provides the designer with useful insights into the dependence of the performance metrics on design variables and fan-out capacitan…
Adaptive independent sticky MCMC algorithms
2018
In this work, we introduce a novel class of adaptive Monte Carlo methods, called adaptive independent sticky MCMC algorithms, for efficient sampling from a generic target probability density function (pdf). The new class of algorithms employs adaptive non-parametric proposal densities which become closer and closer to the target as the number of iterations increases. The proposal pdf is built using interpolation procedures based on a set of support points which is constructed iteratively based on previously drawn samples. The algorithm's efficiency is ensured by a test that controls the evolution of the set of support points. This extra stage controls the computational cost and the converge…
Bayesian inference for the extremal dependence
2016
A simple approach for modeling multivariate extremes is to consider the vector of component-wise maxima and their max-stable distributions. The extremal dependence can be inferred by estimating the angular measure or, alternatively, the Pickands dependence function. We propose a nonparametric Bayesian model that allows, in the bivariate case, the simultaneous estimation of both functional representations through the use of polynomials in the Bernstein form. The constraints required to provide a valid extremal dependence are addressed in a straightforward manner, by placing a prior on the coefficients of the Bernstein polynomials which gives probability one to the set of valid functions. The…
Confined growth of carbon nanoforms in one-dimension by fusion of anthracene rings inside the pores of MCM-41
2014
We report a simple two-step procedure that uses anthracene, a cheap polyaromatic hydrocarbon with low melting point, as a molecular precursor to produce carbon nanoforms (CNFs). First, we describe the chemical synthesis of graphite from the fusion of anthracene rings at relatively low temperature (520 °C) followed by cyclodehydrogenation. Next, we extend this protocol to the synthesis of CNFs by confining the molecular precursor in a mesoporous host like MCM-41. The confined environment favors one-dimensional growth of CNFs with sizes controlled by the pores of the mesoporous host.
Dominant-negative FADD rescues the in vivo fitness of a cytomegalovirus lacking an anti-apoptotic viral gene
2008
ABSTRACT Genes that inhibit apoptosis have been described for many DNA viruses. Herpesviruses often contain even more than one gene to control cell death. Apoptosis inhibition by viral genes is postulated to contribute to viral fitness, although a formal proof is pending. To address this question, we studied the mouse cytomegalovirus (MCMV) protein M36, which binds to caspase-8 and blocks death receptor-induced apoptosis. The growth of MCMV recombinants lacking M36 (ΔM36) was attenuated in vitro and in vivo. In vitro, caspase inhibition by zVAD-fmk blocked apoptosis in ΔM36-infected macrophages and rescued the growth of the mutant. In vivo, ΔM36 infection foci in liver tissue contained sign…
Comparative cytotoxic study of silica materials functionalised with essential oil components in HepG2 cells
2020
[EN] This work evaluated the cytotoxic effect of different EOCs-functionalised silica particle types. The in vitro toxicity of eugenol and vanillin-immobilised SAS, MCM-41 microparticles and MCM-41 nanoparticles was evaluated on HepG2 cells, and compared to free EOCs and pristine materials. The results revealed that free essential oil components and bare silica had a mild cytotoxic effect on HepG2 cells. However, the comparative study showed that free eugenol and vanillin had a milder cytotoxic effect than the equivalent concentrations of immobilised components on the different silica particles, while differences in cell viability between the bare and functionalised particles relied on the …