Search results for "MDMA"
showing 10 items of 51 documents
Neurotoxicity and persistent cognitive deficits induced by combined MDMA and alcohol exposure in adolescent rats
2010
Recent trend assessments of drug consumption reveal an increase in the simultaneous use of several drugs at raves, clubs and college settings among youngsters and young adults. We studied in adolescent rats the effects of repeated exposure to cocaine and 3,4-methylenedioxymethanphetamine (MDMA, ecstasy), given alone or in combination with alcohol, on memory performance, adult hippocampal neurogenesis and neurotoxicity. Rats were trained two weeks after the drug treatments in the radial arm maze. The results showed that only rats exposed to combinations of alcohol and MDMA exhibited significant memory deficits. Alcohol, MDMA and combinations thereof significantly decreased 5-bromodeoxyuridin…
Occurrence of illicit drugs in two wastewater treatment plants in the South of Italy
2017
In this study the occurrence and the behavior of illicit drugs and their metabolites have been investigated for two wastewater treatment plants (WWTPs) (namely, WWTP-1 and WWTP-2) located in Sicily (island of Italy). Samples were analyzed for methamphetamine, cocaine (COC), 3,4-methylenedioxymethamphetamine (MDMA), methadone (METH), 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), 3,4-methylenedioxy amphetamine (MDA); 3,4-methylenedioxy ethylamphetamine (MDEA), 11-nor-9-carboxy-Î9-tetrahydrocannabinol (THC-COOH) and Benzoylecgonine (BEG). The BEG, COC, MOR and THC-COOH were found at the highest concentration in both WWTPs. The Wastewater-based epidemiology calculation for BEG, COC…
Spatio‐temporal assessment of illicit drug use at large scale : evidence from 7 years of international wastewater monitoring
2019
Background and aims Wastewater‐based epidemiology is an additional indicator of drug use that is gaining reliability to complement the current established panel of indicators. The aims of this study were to: (i) assess spatial and temporal trends of population‐normalized mass loads of benzoylecgonine, amphetamine, methamphetamine and 3,4‐methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011–17); (ii) address overall drug use by estimating the average number of combined doses consumed per day in each city; and (iii) compare these with existing prevalence and seizure data. Design Analysis of daily raw wastewater composite samples collected over 1 week per year from 2011 to…
Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I-NBOMe.
2020
[EN] This work reports the synthesis, characterization, and sensing behavior of a hybrid nanodevice for the detection of the potent abuse drug 25I-NBOMe. The system is based on mesoporous silica nanoparticles, loaded with a fluorescent dye, functionalized with a serotonin derivative and capped with the 5-HT2A receptor antibody. In the presence of 25I-NBOMe the capping antibody is displaced, leading to pore opening and rhodamine B release. This delivery was ascribed to 5-HT2A receptor antibody detachment from the surface due to its stronger coordination with 25I-NBOMe present in the solution. The prepared nanodevice allowed the sensitive (limit of detection of 0.6 mm) and selective recogniti…
Comparing illicit drug use in 19 European cities through sewage analysis
2012
Abstract: The analysis of sewage for urinary biomarkers of illicit drugs is a promising and complementary approach for estimating the use of these substances in the general population. For the first time, this approach was simultaneously applied in 19 European cities, making it possible to directly compare illicit drug loads in Europe over a 1-week period. An inter-laboratory comparison study was performed to evaluate the analytical performance of the participating laboratories. Raw 24-hour composite sewage samples were collected from 19 European cities during a single week in March 2011 and analyzed for the urinary biomarkers of cocaine, amphetamine, ecstasy, methamphetamine and cannabis u…
Implicación del sistema serotoninérgico y dopaminérgico en los efectos reforzantes de la MDMA
2012
La adolescencia constituye un periodo de especial vulnerabilidad al consumo de drogas, siendo los adolescentes los principales consumidores de 3,4- metilendioximetanfetamina (MDMA), un derivado anfetamínico con potencial adictivo. El objetivo del presente trabajo es evaluar el papel de los sistemas dopaminérgico y serotoninérgico en las propiedades reforzantes de la MDMA y en la vulnerabilidad a la recaída en su consumo. En concreto, hemos estudiado la implicación de estos sistemas de neurotransmisión en la adquisición, expresión y reinstauración del condicionamiento de preferencia de lugar (CPL) inducido por MDMA en ratones adolescentes. Para ello utilizamos diferentes agonistas y antagoni…
Influences of social stress in the rewarding effects of mdma and alcohol
2015
La adicción a las drogas es un importante problema en nuestra sociedad con graves consecuencias jurídicas, médicas y sociales para los consumidores. Se trata de un trastorno caracterizado por la pérdida de control sobre el uso de la droga, su búsqueda compulsiva y la aparición de un estado emocional negativo en ausencia de la misma. El alcohol es la droga legal más consumida tanto por adultos como por adolescentes. Por otra parte, entre las sustancias ilegales, los datos epidemiológicos apuntan que el éxtasis o MDMA es una sustancia ampliamente consumida entre los adolescentes y adultos jóvenes sobre todo en fiestas “rave” donde los consumidores pasan horas, incluso días, haciendo uso de es…
Cocaine and MDMA Induce Cellular and Molecular Changes in Adult Neurogenic Systems: Functional Implications
2011
The capacity of the brain to generate new adult neurons is a recent discovery that challenges the old theory of an immutable adult brain. A new and fascinating field of research now focuses on this regenerative process. The two brain systems that constantly produce new adult neurons, known as the adult neurogenic systems, are the dentate gyrus (DG) of the hippocampus and the lateral ventricules/olfactory bulb system. Both systems are involved in memory and learning processes. Different drugs of abuse, such as cocaine and MDMA, have been shown to produce cellular and molecular changes that affect adult neurogenesis. This review summarizes the effects that these drugs have on the adult neurog…
Differential effects of MDMA and cocaine on inhibitory avoidance and object recognition tests in rodents.
2017
Introduction Drug addiction continues being a major public problem faced by modern societies with different social, health and legal consequences for the consumers. Consumption of psychostimulants, like cocaine or MDMA (known as ecstasy) are highly prevalent and cognitive and memory impairments have been related with the abuse of these drugs. Aim The aim of this work was to review the most important data of the literature in the last 10 years about the effects of cocaine and MDMA on inhibitory avoidance and object recognition tests in rodents. Development: The object recognition and the inhibitory avoidance tests are popular procedures used to assess different types of memory. We compare th…
Effect of drugs of abuse on social behaviour: a review of animal models.
2015
Social behaviour is disturbed in many substance abuse and psychiatric disorders. Given the consensus that social behaviours of lower mammals may help to understand some human emotional reactions, the aim of the present work was to provide an up-to-date review of studies on the changes in social behaviour induced by drugs of abuse. Various animal models have been used to study the relationship between drugs of abuse and social behaviour. Herein, we describe the effects of different substances of abuse on the three most commonly used animal models of social behaviour: the social play test, the social interaction test and the resident-intruder paradigm. The first is the most widely used test t…