Search results for "MDR"

showing 10 items of 35 documents

Decreased Time to Treatment Initiation for Multidrug-Resistant Tuberculosis Patients after Use of Xpert MTB/RIF Test, Latvia

2016

This test decreased time to treatment initiation by 66%–84%.

0301 basic medicineOncologyMaleEpidemiologylcsh:Medicine0302 clinical medicine1108 Medical MicrobiologyTuberculosis Multidrug-Resistant030212 general & internal medicinebacteriaDecreased Time to Treatment Initiation for Multidrug-Resistant Tuberculosis Patients after Use of Xpert MTB/RIF Test Latviabiologytime to treatment initiationDrug Resistance MicrobialMiddle Agedmultidrug-resistant tuberculosisRifampin resistanceInfectious Diseases1117 Public Health And Health ServicesTuberculosis Multidrug-Resistant/diagnosisFemaleRifampinLife Sciences & BiomedicineMicrobiology (medical)Adultmedicine.medical_specialtyTuberculosisAdolescentpulmonary030106 microbiologyXpert MTB/RIFImmunologyTime to treatmentMicrobiologylcsh:Infectious and parasitic diseasesTime-to-TreatmentMycobacterium tuberculosismolecular diagnostics03 medical and health sciencesYoung AdultAntibiotic resistancemultidrug resistanceInternal medicinemedicineHumanslcsh:RC109-216Multivariable modelantimicrobial resistanceTuberculin testAntibiotics AntitubercularScience & Technologybusiness.industryTuberculin TestResearchlcsh:RMycobacterium tuberculosis/drug effects1103 Clinical SciencesMycobacterium tuberculosisbiology.organism_classificationmedicine.diseaseAntibiotics Antitubercular/pharmacologyLatviatuberculosis and other mycobacteriaMultiple drug resistanceMODELTuberculin Test/methodsbusinessRifampin/pharmacologyMDR TB
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Self-reported antibiotic stewardship and infection control measures from 57 intensive care units: An international ID-IRI survey

2022

Infection control; Multidrug resistance; Stewardship Control de infección; Resistencia a múltiples fármacos; Administración Control d'infecció; Resistència a múltiples fàrmacs; Administració We explored the self-reported antibiotic stewardship (AS), and infection prevention and control (IPC) activities in intensive care units (ICUs) of different income settings. A cross-sectional study was conducted using an online questionnaire to collect data about IPC and AS measures in participating ICUs. The study participants were Infectious Diseases–International Research Initiative (IDI-IR) members, committed as per their institutional agreement form. We analyzed responses from 57 ICUs in 24 countri…

:Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]EpidemiologyIntensive Care UnitInfection controlAmerica:acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antibacterianos [COMPUESTOS QUÍMICOS Y DROGAS]Multidrug resistanceCommunicable DiseasesEnquestesPan drug resistanceCommunicable DiseaseAntimicrobial StewardshipSurveys and QuestionnairesAnti-Bacterial AgentHumansMedicaments antibacterians - Ús terapèuticStewardshipSurveys and QuestionnaireSocietyUnitats de cures intensivesCross-Sectional StudieInfection ControlCross InfectionPreventionPublic Health Environmental and Occupational Health:técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]General MedicineMDROAnti-Bacterial AgentsIntensive Care Units:Health Care Facilities Manpower and Services::Health Facilities::Hospital Units::Intensive Care Units [HEALTH CARE]Cross-Sectional StudiesInfectious Diseases:instalaciones servicios y personal de asistencia sanitaria::centros sanitarios::unidades hospitalarias::unidades de cuidados intensivos [ATENCIÓN DE SALUD]:Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents [CHEMICALS AND DRUGS]Self ReportMDROsLow- and upper-middle and high incomeHuman
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Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

ABCC1 ATP binding cassette subfamily C member 1IC50 half maximal inhibitory concentrationMultidrug resistancePharmacologyNADPH reduced nicotinamide adenine dinucleotide phosphateF bioavailabilitychemistry.chemical_compoundPCR polymerase chain reaction0302 clinical medicineMDR multidrug resistanceECL electrochemiluminescencet1/2 elimination half-lifeLC–MS liquid chromatography coupled with mass spectrometryN.D. not detectedGeneral Pharmacology Toxicology and PharmaceuticsBBB blood–brain barriermedia_commonATF3 activating transcription factor 30303 health sciencesChemistryABC ATP-binding cassetteNMPA National Medical Products AdministrationPXR pregnane X receptorSDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresisHBSS Hankʹs balanced salt solutionABCB1Combination chemotherapyProdrugMarsdenia tenacissimaCmax peak concentrationPaclitaxelGAPDH glyceraldehyde-3-phosphate dehydrogenase030220 oncology & carcinogenesisBHI brain heart infusionOriginal ArticleAUC0–∞ area under plasma concentration vs. time curveMRT mean residence timeDrugmedia_common.quotation_subjectRM1-950Vd volume of distributionABCB1 ATP binding cassette subfamily B member 1UIC-2 mouse monoclonal ABCB1 antibodyABCG2 ATP binding cassette subfamily G member 2Combination chemotherapyCYP cytochrome P450 isozymePI propidium iodideTEER transepithelial electrical resistance03 medical and health sciencesPBS phosphate buffer salineFBS fetal bovine serumDox doxorubicinIn vivoPOP polyoxypregnanemedicine030304 developmental biologyEVOM epithelial tissue voltohmmeterTmax time for peak concentrationCancerLBE lowest binding energyPE phycoerythrinmedicine.diseaseMultiple drug resistancePolyoxypregnanePapp apparent permeabilityN.A. not applicableCancer cellH&E hematoxylin and eosinMDR1a multidrug resistance protein 1aTherapeutics. PharmacologyqPCR quantitative PCRM. tenacissima Marsdenia tenacissimaCL clearanceSD standard derivationActa Pharmaceutica Sinica B
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Selective downregulation of the MDR1 gene product in Caco-2 cells by stable transfection to prove its relevance in secretory drug transport.

2005

Considerable interest is focused on overcoming multidrug resistance (MDR) in cancer chemotherapy. The in vitro experiments to characterize P-glycoprotein's (P-gp) function and to decrease its effects have led to a variety of strategies such as addition of competitors or supplementation of the medium with oligonucleotides complementary to the 5'-end of the MDR1-mRNA. For the Caco-2 cell line, an in vitro model for absorption screening, expressing multiple transporters including P-gp, which pumps substances back into the apical solution, P-gp activity might mask other relevant transport proteins' activity. The objective of the present study was to construct a Caco-2 subline with reduced P-gp …

ATP Binding Cassette Transporter Subfamily BTime FactorsPharmaceutical ScienceDown-RegulationBiologyTransfectionPermeabilityPropanolaminesDownregulation and upregulationDrug DiscoveryHumansNorthern blotOligonucleotideReverse Transcriptase Polymerase Chain ReactionElectroporationBiological TransportTransfectionFlow CytometryMolecular biologyIn vitroTransport proteinClone CellsMutagenesis InsertionalVerapamilCell cultureMolecular MedicineCaco-2 CellsGenes MDRMolecular pharmaceutics
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Molecular epidemiology of Acinetobacter baumannii in Iran: endemic and epidemic spread of multiresistant isolates

2014

Objectives We examined the molecular epidemiology of Acinetobacter baumannii clinical isolates from two cities (Tehran and Tabriz) of Iran. Methods DiversiLab repetitive extragenic palindromic PCR (rep-PCR), multilocus sequence typing and sequence group multiplex PCR were performed. The presence of resistance mechanisms including metallo-β-lactamases, extended-spectrum β-lactamases, OXA carbapenemases, aminoglycoside-modifying enzymes and RNA methylases was also investigated. Results DiversiLab rep-PCR identified 11 clusters and 11 singleton isolates. Twelve sequence types (STs), including six novel types, were identified. Sequence groups (SGs) 1-3 as well as five additional banding pattern…

Acinetobacter baumanniiMicrobiology (medical)Settore MED/07 - Microbiologia E Microbiologia ClinicaGenotypeIranBiologySettore MED/42 - Igiene Generale E ApplicataMicrobiologySequence-tagged siteDrug Resistance Multiple BacterialMultiplex polymerase chain reactionCluster AnalysisHumansPharmacology (medical)CitiesPharmacologyGeneticsMolecular EpidemiologyMolecular epidemiologyGenetic VariationOutbreakbiology.organism_classificationTRNA MethyltransferasesAcinetobacter baumanniiMolecular TypingMultiple drug resistanceAcinetobacter baumannii MDR Iran molecular epidemiologyInfectious DiseasesMultilocus sequence typingAcinetobacter InfectionsJournal of Antimicrobial Chemotherapy
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Dissemination of a Carbapenem-Resistant Acinetobacter baumannii Strain Belonging to International Clone II/Sequence Type 2 and Harboring a Novel AbaR…

2013

ABSTRACT An outbreak of hospital-acquired Acinetobacter baumannii infections, caused by a bla OXA-23 -positive carbapenem-resistant strain belonging to international clone II/ST2, was detected in Latvia. The strain was partially equipped with the armA gene and the intI1-aacA4-catB8-aadA1-qacE Δ 1 class 1 integron. In addition, the strain carried AbaR25, a novel AbaR4-like resistance island of ∼46,500 bp containing structures similar to the previously described AbaR22 and Tn 6167 islands. AbaR25 was characterized by the occurrence of a second copy of Tn 6022a interrupted by Tn 2006 carrying the bla OXA-23 gene.

Acinetobacter baumanniiclone (Java method)Genomic IslandsMolecular Sequence DataMicrobial Sensitivity TestsIntegronbeta-Lactam Resistancebeta-LactamasesDisease OutbreaksIntegronsMicrobiologyMechanisms of ResistancePharmacology (medical)GeneVDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical molecular biology: 711Sequence (medicine)PharmacologyCross InfectionMolecular EpidemiologyMolecular epidemiologyStrain (chemistry)biologyOutbreakMethyltransferasesVDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical microbiology: 715biology.organism_classificationLatviaAnti-Bacterial AgentsBacterial Typing TechniquesAcinetobacter baumanniiInfectious DiseasesCarbapenemsVDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715DNA Transposable Elementsbiology.proteinGenes MDRVDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical immunology: 716VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711Acinetobacter Infections
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Correlation between GP-170 expression, prognosis, and chemoresistance of superficial bladder carcinoma.

2003

To study GP-170 in superficial bladder cancer at initial diagnosis and at recurrence and to evaluate if intravesical chemoprophylaxis modifies the expression of GP-170 in tumor recurrences. GP-170 was retrospectively assessed in 160 patients affected by primary superficial transitional cell carcinoma of the bladder and followed for up to 10 years. Eighty-four patients (52.5%) recurred after transurethral resection (TUR). Adjuvant intravesical chemotherapy after TUR was adopted in 52 patients. The correlations between GP-170 and G-grade, T-category, risk of recurrence and of progression, and adoption of adjuvant intravesical chemotherapy were investigated. The correlations between variations…

AdultMaleCancer Researchmedicine.medical_specialtyPathologymedicine.medical_treatmentUrologySettore MED/24 - UrologiaSuperficial bladder carcinoma GP-170 MDR-1 Prognosis Intravesical chemotherapyInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineCarcinomaHumansATP Binding Cassette Transporter Subfamily B Member 1Stage (cooking)AgedRetrospective StudiesChemotherapyHematologyUrinary bladderbusiness.industryGeneral MedicineMiddle Agedmedicine.diseasePrognosisDrug Resistance MultipleGene Expression Regulation NeoplasticTransitional cell carcinomamedicine.anatomical_structureOncologyUrinary Bladder NeoplasmsChemotherapy AdjuvantDrug Resistance NeoplasmChemoprophylaxisFemaleSuperficial Bladder CarcinomaGenes MDRNeoplasm Recurrence LocalbusinessFollow-Up StudiesJournal of cancer research and clinical oncology
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OCT is not useful for detection of minimal diabetic retinopathy in type 1 diabetes.

2009

Optical coherence tomography (OCT) has been proven useful in measuring retinal thickness (RT) in patients with diabetes, although with discordant results in different studies. We examined RT in patients with type 1 diabetes (T1D) with or without minimal diabetic retinopathy (MDR) to test whether OCT is able to identify early retinal changes and potential correlations with metabolic parameters. RT of 102 patients with T1D (53 females, 49 males, aged 27.03 +/- 7.4 years) and of 42 healthy controls was examined, with analysis of nine different sectors (fovea, four pericentral and four peripheral sectors). According to the results of basal fundus photography, patients were divided into two grou…

AdultMalemedicine.medical_specialtyEndocrinology Diabetes and MetabolismGastroenterologyRetinaSettore MED/13 - EndocrinologiaYoung AdultEndocrinologyOptical coherence tomography (OCT) type 1 diabetes (T1D) minimal diabetic retinopathy (MDR)retinal thickness (RT)Predictive Value of TestsInternal medicineDiabetes mellitusInternal MedicinemedicineHumansHypoglycemic AgentsInsulinMacular edemaType 1 diabetesDiabetic Retinopathymedicine.diagnostic_testbusiness.industrySettore MED/30 - Malattie Apparato VisivoFundus photographyGeneral MedicineDiabetic retinopathymedicine.diseaseRadiographyEndocrinologyDiabetes Mellitus Type 1Predictive value of testsMicroalbuminuriaFemalebusinessMedical FutilityTomography Optical CoherenceRetinopathy
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Zvaigžņotā Debess: 2017, Pavasaris (235)

2017

Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: E.Mūkins. Clouds of Venus: Structure and Composition (abridged) ; J.Miezis. 3rd All-union Young Astronomers Gathering (abridged) ; DEVELOPMENTS in SCIENCE: K.Schwartz. New Discoveries in the Milky Way ; DISCOVERIES: I.Eglītis. Small Planets Get Latvian Names ; I.Pundure. Earth-mass World Revealed around Proxima Centauri ; SPACE RESEARCH and EXPLORATION: J.Jaunbergs. Mysteries of Saturn’s Clouds ; A.Slavinskis. Contribution of Estonian Student Satellite Programme ESTCube to Largest Challenges for Humanity ; R.Misa. Impossible Engine that Is likely Possible ; I.Pundure. ESO VLT to Search for Planets in Alpha Centauri System ; EARTH and COSMOS: J.…

Akadēmiķim Oļģertam Dumbrājam – Artura Balklava balva 2017Kosmologs un matemātiķis abats Žoržs LemetrsStarptautiskā matemātikas olimpiāde 2015 – uzdevumu atrisinājumiErnestam Ābelem – 110Pasaules laiks UTC 31.XII 2016. liekā sekunde un LU AI atompulkstenisAsteroīdi – Saule EglitisZemes masas citplanēta Proxima bDzinējs EmDriveIgaunijas Studentu satelītu programma ESTCubeZemes vulkānismsLU Astronomiskais tornis – trešā desmitgadePiena Ceļa galaktika – struktūraSeminārs “Ērglis 2016” MazsalacāESO VLT – planētas Centaura Alfas sistēmāMārīte Eglīte (1951-2016)Vidējās masas melnā cauruma kandidātsTiho Brahe Vēnas salāDebess spīdekļi – 2017.gada pavasarisAgrim J. Kalnājam – 80Nozīmīgākie sasniegumi Latvijas zinātnē 2016:NATURAL SCIENCES::Physics::Astronomy and astrophysics [Research Subject Categories]Saturns – atmosfēraĶīnas nesējraķete CZ-5Mārim Ābelem – 80Zvaigžņotais visums grafikas mākslāIzstāde LU Bibiliotēkā – ar Latviju saistīti asteroīdu nosaukumi
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Asymmetric synthesis and biological evaluation of 1,2,4-Oxadiazoles analogues of Linezolid

2014

Oxazolidinones are a class of antibacterial agents which displayed activity againist a variety of gram-positive pathogens and are highly potent against multidrug-resistant bacteria. Linezolid is the first oxazolidinone antibiotic approved for clinical use but linezolid resistance began to appear. 1,2,4 – Oxadiazoles are known bioactive heterocycles whose activity has been often associated to their bioisosterism with amide or ester functionalities [1]. As results of a research project on the molecular design of heterocycle – based antibacterials to contrast Multi-Drug Resistance (MDR) [2], we report the synthesis of 1,2,4 - Oxadiazole analogues of Linezolid. The synthesis has been achieved b…

Antibacterials oxadiazoles Linezolid MDR-MRSASettore CHIM/06 - Chimica Organica
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