Search results for "MEK"
showing 10 items of 844 documents
Projektu un klientu moduļa izstrāde personālvadības sistēmā
2019
Kvalifikācijas darbā "Projektu un klientu moduļa izstrāde personālvadības sistēmā", izstrādāti tīmekļa lietojumprogrammas "Tildes Jumis Personāls" projektu un klientu moduļi, kas personālvadības sistēmas lietotājiem ļauj sistēmā reģistrēt projektus un klientus, kā arī reģistrētos projektus sasaistīt ar sistēmā reģistrētajiem klientiem un darbiniekiem un to amatiem. Izstrādātie moduļi ir sistēmas funkcionalitātes papildinājumu pirmais etaps, un tos tālāk paredzēts izmantot, lai sistēmas lietotājiem nodrošinātu iespēju norakstīt darbinieku darba stundas pa projektiem. Moduļu izstrādē izmantotās tehnoloģijas ir Angular, Microsoft .NET Core, DevExtreme.
"Māci un mācies", tiešsaistes kursu vietne
2022
Kvalifikācijas darba mērķis ir izstrādāt tīmekļa vietni, kas palīdzētu Latvijas iedzīvotājiem dalīties ar savām zināšanām un iegūt jaunas zināšanas, veidojot un skatoties elektroniskus kursus. Lietotāji var izveidot, rediģēt, dzēst savus kursus, pievienot tiem sadaļas un nodarbības un augšupielādēt nodarbībām video, kā arī dokumentus. Dokumentu un video augšupielādei, uzglabāšanai un iegūšanai tiek izmantots Cloudinary serviss. Ja kursa redzamība ir iespējota, tad šo kursu var redzēt jebkurš cits reģistrēts lietotājs. Neatbilstoša satura izveides gadījumā, administratoram ir tiesības dzēst, rediģēt kursu vai tā saturu. Tīmekļa vietne ir izstrādāta uz mikroservisu arhitektūras pamatu, lai bū…
Tīmekļa pakalpes izstrāde, izmantojot Windows Communication Foundation platformu
2019
Bakalaura darbā tiek pētīts, kā veidot tīmekļa pakalpes, izmantojot Windows Communication Foundation (WCF) platformu. Tiek aplūkoti galvenie pakalpju veidošanas principi un pakalpju drošības, ātrdarbības un citi aspekti. Praktiskajā daļā tiek realizēta tīmekļa pakalpe, izmantojot izpētītos principus un WCF, un salīdzināta ar cita veida tehnoloģiju.
Using hydrological connectivity to detect transitions and degradation thresholds: Applications to dryland systems
2020
In arid and semi-arid ecosystems, shortage of water can trigger changes in landscapes’ structures and function leading to degradation and desertification. Hydrological connectivity is a useful framework for understanding water redistribution and scaling issues associated with runoff and sediment production, since human and/or natural disturbances alter surface water availability and pathways increasing/decreasing connectivity. In this paper, we illustrate the use of the connectivity framework for several examples of dryland systems that are analysed at a variety of spatial and temporal scales. In doing so, we draw particular attention to the analysis of coevolution of system structures and …
Ecological conditions alter cooperative behaviour and its costs in a chemically defended sawfly
2018
The evolution of cooperation and social behaviour is often studied in isolation from the ecology of organisms. Yet, the selective environment under which individuals evolve is much more complex in nature, consisting of ecological and abiotic interactions in addition to social ones. Here, we measured the life-history costs of cooperative chemical defence in a gregarious social herbivore, Diprion pini pine sawfly larvae, and how these costs vary under different ecological conditions. We ran a rearing experiment where we manipulated diet (resin content) and attack intensity by repeatedly harassing larvae to produce a chemical defence. We show that forcing individuals to allocate more to coope…
Stratification strength and light climate explain variation in chlorophyll a at the continental scale in a European multilake survey in a heatwave su…
2021
The authors acknowledge COST Action ES 1105 "CYANOCOST Cyanobacterial blooms and toxins in water resources: Occurrence impacts and management" and COST Action Global Change Biology ES 1201 NETLAKE -Networking Lake Observatories in Europe" for contributing to this study through networking and knowledge sharing with European experts in the field. We acknowledge the members of the Global Lake Ecological Observatory Network (GLEON) for their collaborative spirit and enthusiasm that inspired the grassroots effort of the EMLS. E.M. was supported by a grant from the Swiss State Secretariat for Education, Research and Innovation to Bas Ibelings and by supplementary funding from University of Geneva…
Antipredator strategies of pupae: how to avoid predation in an immobile life stage?
2019
Antipredator strategies of the pupal stage in insects have received little attention in comparison to larval or adult stages. This is despite the fact that predation risk can be high during the pupal stage, making it a critical stage for subsequent fitness. The immobile pupae are not, however, defenceless; a wide range of antipredator strategies have evolved against invertebrate and vertebrate predators. The most common strategy seems to be ‘avoiding encounters with predators' by actively hiding in vegetation and soil or via cryptic coloration and masquerade. Pupae have also evolved behavioural and secondary defences such as defensive toxins, physical defences or deimatic movements and soun…
Inferring causation from time series in earth system sciences
2019
The heart of the scientific enterprise is a rational effort to understand the causes behind the phenomena we observe. In large-scale complex dynamical systems such as the Earth system, real experiments are rarely feasible. However, a rapidly increasing amount of observational and simulated data opens up the use of novel data-driven causal methods beyond the commonly adopted correlation techniques. Here, we give an overview of causal inference frameworks and identify promising generic application cases common in Earth system sciences and beyond. We discuss challenges and initiate the benchmark platform causeme.net to close the gap between method users and developers.
RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinoma
2019
Introduction: Hepatocellular carcinoma (HCC) is a significant problem globally because of viral infections and the increasing incidence of obesity and fatty liver disease. However, it is difficult to treat because its inherent genetic heterogeneity results in activation of numerous signaling pathways. Kinases have been targeted for decades with varying results, but the development of therapeutic resistance is a major challenge. Areas covered: The key roles of the RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1, TP53 microRNAs (miRs) as therapeutic targets are discussed and we suggests novel approaches for targeting miRs or their downstream targets to combat HCC. We performed literature searches using…
PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer
2017
AbstractCombined MAPK/PI3K pathway inhibition represents an attractive, albeit toxic, therapeutic strategy in oncology. Since PTEN lies at the intersection of these two pathways, we investigated whether PTEN status determines the functional response to combined pathway inhibition. PTEN (gene, mRNA, and protein) status was extensively characterized in a panel of cancer cell lines and combined MEK/mTOR inhibition displayed highly synergistic pharmacologic interactions almost exclusively in PTEN-loss models. Genetic manipulation of PTEN status confirmed a mechanistic role for PTEN in determining the functional outcome of combined pathway blockade. Proteomic analysis showed greater phosphoprote…