Search results for "MEP"
showing 10 items of 209 documents
Effect of vildagliptin compared to glimepiride on postprandial proinsulin processing in the β cell of patients with type 2 diabetes mellitus
2012
This study compared the effect of Glimepiride versus Vildagliptin on β-cell function and the release of intact proinsulin (PI) in patients with type 2 diabetes mellitus. Patients on metformin monotherapy were randomized to add on treatment with Vildagliptin or Glimepiride. A standardized test meal was given at baseline, after 12 and 24 weeks of treatment. Insulin, PI and blood glucose values were measured in the fasting state and postprandial for 300 min. Fasting PI levels significantly decreased in the Vildagliptin group. The area under the curve for the postprandial release of PI decreased during Vildagliptin and increased during Glimepiride treatment. The proinsulin to insulin ratio decl…
Effect of gastric acid suppression on 13 C-urea breath test: comparison of ranitidine with omeprazole
2000
Background: The assessment of the effect of H2 antagonists on the results of the urea breath test has produced controversial results. Aim: To assess whether standard doses of both omeprazole and H2 blockers can adversely influence the accuracy of the urea breath test. Methods: Sixty dyspeptic patients with ascertained Helicobacter pylori infection were recruited for this prospective, open study. They were randomized to receive either omeprazole 20 mg at 08:00 hours (n = 30) or ranitidine 300 mg at 22:00 hours (n = 30) for 14 days. The urea breath test was performed at baseline, on day 14, while patients were still taking the antisecretory drugs, and on day 21, 1 week after their cessation. …
A Versatile and Convenient Method for the Functionalization of Porphyrins
2001
International audience; The condensation of 3-(chloromethyl)benzoyl chloride with different atropisomers of meso-(tetra-o-aminophenyl)porphyrin (TAPP), followed by the reaction of a series of nucleophilic reagents leads, among others, to precursors of biomimetic models of heme proteins such as cytochrome c oxidase (CcO). This synthesis can also be applied as an efficient two-step reaction to obtain highly functionalized porphyrin derivatives potentially useful for cation binding.
ON THE OCCURRENCE OF RESPIRATORY COMPONENTS IN RAT-LIVER NUCLEI.
1965
Summary 1. Low-temperature spectrophotometric studies have been carried out on rat-liver nuclei isolated by two different procedures. Comparison of nuclei prepared in non-aqueous media with those prepared in high-density sucrose reveals only small quantitative differences. 2. The presence of hemoglobin, cytochrome b 5 , and cytochrome c was detected in both types of nuclei. No cytochrome b , or cytochrome oxidase could be found. Studies on the possible origin of the hemoproteins suggest that hemoglobin and cytochrome b 5 are of extra-nuclear origin. The presence of cytochrome c as a nuclear component could not be ruled out completely although leakage from mitochondria was also considered a …
Analysis of pharmaceutical preparations containing local anesthetics by micellar liquid chromatography and spectrophotometric detection
1999
An HPLC procedure for the determination of six local anesthetics, bupivacaine, lidocaine, mepivacaine, procaine, propanocaine and tetracaine, in pharmaceutical silane ODS-2 C18 analytical column and spectrophotometric detection at 230 nm were used. The chromatographic tographic behaviour of local anesthetics with different micellar eluents of sodium dodecyl sulphate (SDS) is described. Selection of the adequate composition of the micellar mobile phase (SDS and 1-propanol concentrations) for the analysis of pharmaceuticals was studied. Adequate retention was achieved with an eluent containing 0.15 M SDS +10% 1-propanol at pH 3. Application of the proposed method to the analysis of eight phar…
Alkaline haematin D-575, a new tool for the determination of haemoglobin as an alternative to the cyanhaemiglobin method. I. description of the method
1984
A new method for the rapid and accurate measurement of haemoglobin has been developed as an alternative to the conventional cyanhaemiglobin method. This method is based on the conversion of all haeme, haemoglobin, and haemiglobin species into a stable end product by an alkaline solution of a non-ionic detergent ('AHD reagent'). The reaction product, designated as alkaline haematin D-575, is extremely stable and shows a characteristic absorption peak at 575 nm. As compared to the cyanhaemiglobin method, the determination of haemoglobin by alkaline haematin D-575 offers several advantages such as (1) extreme stability of the AHD reagent and the conversion product, (2) decreased conversion tim…
Enantioseparation of phenotiazines by affinity electrokinetic chromatography using human serum albumin as chiral selector
2007
Nowadays, there is a special interest within the pharmaceutical laboratories to develop single enantiomer formulations and consequently a need for analytical methods to determine the enantiomeric purity of drugs. The present paper deals with the enantiomeric separation of promethazine and trimeprazine enantiomers by affinity electrokinetic chromatography (AEKC)-partial filling technique using human serum albumin (HSA) as chiral selector. A multivariate optimization of the most critical experimental variables in enantioresolution, running pH, HSA concentration and plug length, is carried out to obtain enantioresolution of promethazine and trimeprazine. The estimated maximum and optimum resol…
New Anti-Neoplastics Obtained by a Molecular Connectivity Method
2000
Molecular Connectivity is a method, which allows to discriminate different pharmacological activities on the basics of numeric parameters of the molecules in study, related with specific and exclusive indexes. In the present study, we propose two potentially anti-neoplasic compounds: tricromil and zomepirac, by analyzing more than a hundred different chemicals.
Blending in Hybrid Games: Understanding Hybrid Games Through Experience
2016
The meaning of what hybrid games are is often fixed to the context in which the term is used. For example, hybrid games have often been defined in relation to recent developments in technology. This creates issues in its usage and limitations in thinking. This paper argues that hybrid games should be understood through conceptual metaphors. Hybridity is the blending of different cognitive domains that are not usually associated together. Hybrid games usually blend domains related to games, for example digital and board games, but can blend also other domains. Through this type of thinking, designers can be more open to exploring how their games can be experienced.
Life-Cycle Land-Use Requirement for PV in Vietnam
2021
Over the last 15 years, photovoltaics (PV) in Vietnam has experienced development. The increased installed capacity of PV requires more land for installation sites as well as for manufacturing the plants’ component and waste treatment during the plants’ decommissioning. As a developing country, in which more than 80% of the population’s livelihood depends on agriculture, there are concerns about the competition of land for agriculture and solar development. This paper estimates the life-cycle land-use requirement for PV development in Vietnam, to provide the scientific-based evidence for policy makers on the quantity of land required, so that the land budget can be suitably allocated. The d…