Search results for "MIDI"
showing 10 items of 1431 documents
"Click" on PLGA-PEG and hyaluronic acid: gaining access to anti-leishmanial pentamidine bioconjugates
2018
Pentamidine (Pent), an antiparasitic drug used for the treatment of visceral leishmaniasis, has been modified with terminal azide groups and conjugated to two different polymer backbones (PLGA-PEG [PP] copolymer and hyaluronic acid [HA]) armed with alkyne end-groups. The conjugation has been performed by Copper Catalyzed Azido Alkyne Cycloaddition (CuAAC) using CuSO4/sodium ascorbate as metal source. The novel PP-Pent and HA-Pent bioconjugates are proposed, respectively, as non-targeted and targeted drug delivery systems against Leishmania infections. Moreover, Pent has been encapsulated into PP nanoparticles by the oil-in-water emulsion method, with the aim to compare the biological activi…
Leukemic Colony-Forming Cells in Acute Myeloblastic Leukemia: Maturation Hierarchy and Growth Conditions
1987
Despite their primitive morphological appearance, the majority of leukemic blasts in acute myeloblastic leukemia (AML) are end-stage, nonproliferating cells. Only a small subset of AML blasts are capable of a sufficient number of divisions to form colonies in semisolid medium [1, 2]. It has been suggested that these leukemic colony-forming cells (L-CFC) may act in vivo as progenitor cells to maintain the rest of the leukemic cell population [3, 4]. L-CFC share several properties with normal myeloid progenitor cells, including self-renewal potential and high thymidine suicide index [2, 3]. As in the case of normal myeloid progenitor cells (NMPC), colony growth of L-CFC from most patients req…
Vaporization Characteristics of Ethanol Droplets: Influence of the Environment Humidity
2011
The study of the gasification of a droplet via vaporization, which involves heat, mass and momentum transfer processes in gas and liquid phases, and their coupling at the droplet interface, is necessary for better understanding and modeling of complex spray and mixture formation issues. A detailed description of the vaporization of an isolated droplet has been realized in this experimental study aimed at investigating the impact of the water vapor contained in the surrounding gas on the evaporation of an ethanol droplet. The experimental set-up consists of a heated chamber with a cross quartz fibers configuration as droplet support. An ethanol droplet is located at the intersection of the c…
In vitro evaluation of glycol chitosan based formulations as oral delivery systems for efflux pump inhibition.
2017
Recently, we have reported that glycol chitosan (GCS) was able to reverse the P- glycoprotein (P-gp) efflux pump. The objective of the present study was to evaluate the potential of two GCS-based dosage forms (aqueous solution or nanoparticle suspension) for oral administration of the P-gp substrate Rho-123. A further aim of the present study was to assess the effect of the glycol chitosan-4-thiobutylamidine thiomer (GCS-TBA) on P-gp activity considering that the corresponding thiomer of chitosan series is a well-known P-gp inhibitor. Pre-treatment of Caco-2 cell monolayer with a GCS solution or GCS-based nanoparticles increased the absorptive transport of Rho-123 across the monolayer of 1.…
Effects of dexamethasone on human synovial fibroblast-like cells, from osteoarthritic joints, in culture.
1990
The effect of Dexamethasone (DEX) on cell division and macromolecular synthesis was investigated in a line (McCoy cells, A 9) of synovial fibroblast-like cells derived from human osteoarthritic joints. DEX markedly reduced the proliferation of McCoy cells in a time and dose-dependent manner. The maximal inhibition (45%) was found at 500 nM DEX 24 h after incubation and was accompanied by the appearance of giant macrophage-like cells. After DEX treatment cells showed increased content of DNA, proteins and RNA together with the reduction of [3H]-thymidine incorporation into the TCA-precipitable fraction.
A Battery-Free Wireless Smart Sensor platform with Bluetooth Low Energy Connectivity for Smart Agriculture
2022
Smart agriculture systems, which integrate sensors and data analysis into agricultural production processes, are increasingly proving an effective solution for reducing food production waste, yield production increase, and product quality improvement. In this context, this paper deals with a wireless sensors platform for humidity, temperature, and light detection that has the peculiarity to be self-powered and battery-free. The main advantage of the proposed solution is the elimination of maintenance interventions due to battery replacement. Therefore, the availability of install-and-forget sensors allows an easy diffusion for a capillary detection of plant health and growth parameters thro…
SMOS-IC: An Alternative SMOS Soil Moisture and Vegetation Optical Depth Product
2017
© 2017 by the authors. The main goal of the Soil Moisture and Ocean Salinity (SMOS) mission over land surfaces is the production of global maps of soil moisture (SM) and vegetation optical depth (τ) based on multi-angular brightness temperature (TB) measurements at L-band. The operational SMOS Level 2 and Level 3 soil moisture algorithms account for different surface effects, such as vegetation opacity and soil roughness at 4 km resolution, in order to produce global retrievals of SM and τ. In this study, we present an alternative SMOS product that was developed by INRA (Institut National de la Recherche Agronomique) and CESBIO (Centre d'Etudes Spatiales de la BIOsphère). One of the main go…
Stima da remoto delle caratteristiche evapotraspirative e di umidità del sistema suolo-vegetazione di un impianto viticolo su morfologia complessa
2009
Obiettivo della ricerca è la messa a punto di tecniche di elaborazione d’immagini telerilevate al fine di analizzare le caratteristiche evapotraspirative e di umidità del sistema suolo-vegetazione. La valutazione di tali grandezze è, infatti, di notevole interesse poiché consente alle aziende viticole di ottimizzare i processi di produzione nonché la qualità del prodotto. L’evapotraspirazione effettiva del sistema suolo-vegetazione (ETa) è stata stimata mediante l’applicazione del SEBAL (Surface Energy Balance Algorithm for Land), un modello di bilancio energetico facente uso d’immagini telerilevate nel campo riflessivo ed emissivo dello spettro. Il modello, implementato nella versione Moun…
One-pot synthesis of fluorinated 2-amino-pyrimidine-N-oxides. Competing pathways in the four-atom side-chain rearrangements of 1,2,4-oxadiazoles
2006
Abstract Trifluoromethylated 2-amino-pyrimidine N-oxides have been synthesized by reaction of the 3-amino-5-methyl-1,2,4-oxadiazole with trifluoromethyl-β-diketones in the presence of perchloric acid, followed by hydrolysis. In this ring-to-ring transformation an initial formation of (unisolated) 1,2,4-oxadiazole-pyrimidinium salts, and subsequent ring-opening at the oxadiazole moiety occurs. Isolation of 2-(hydroxyamino)-pyrimidine from the reaction mixture evidenced the presence of a competing pathway where the N(4) nitrogen of the oxadiazole is involved in the formation of a regioisomeric pyrimidinium salt. The effect of the trifluoromethyl group on the product distribution is discussed.…
Sorption kinetic of aroma compounds by edible bio-based films from marine-by product macromolecules: Effect of relative humidity conditions
2019
International audience; Edible films based on gelatin and chitosan have high gas and aroma barrier properties. This study focused on their capability to sorbed/retain aroma compounds (1-hexanal, 2-hexen-1-ol, 1-hexanol, 3-hexanone and phenol) at three relative humidity level (≤2%, 53% or 84% RH). Whatever the relative humidity condition, the order of sorption is keton (3-hexanone) < aldehyde (1-hexanal) < aliphatic alcohols (2-hexen-1-ol and 1-hexanol) < phenol. This order could be related to the intrinsic chemical properties of aroma compounds. The increase in moisture enhanced the sorption at the highest RH for all the aroma compounds. However, a competition between water and aliphatic al…