Search results for "MIDI"

showing 10 items of 1431 documents

Discovery of a new class of sortase a transpeptidase inhibitors to tackle gram-positive pathogens: 2-(2-phenylhydrazinylidene)alkanoic acids and rela…

2016

A FRET-based random screening assay was used to generate hit compounds as sortase A inhibitors that allowed us to identify ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate as an example of a new class of sortase A inhibitors. Other analogues were generated by changing the ethoxycarbonyl function for a carboxy, cyano or amide group, or introducing substituents in the phenyl ring of the ester and acid derivatives. The most active derivative found was 3-oxo-2-(2-(3,4dichlorophenyl)hydrazinylidene)butanoic acid (2b), showing an IC50 value of 50 µM. For a preliminary assessment of their antivirulence properties the new derivatives were tested for their antibiofilm activity. The most active compo…

sortase A; biofilms; 2-(2-phenylhydrazinylidene)alkanoic acid derivatives; FRET0301 basic medicineStaphylococcus aureusStereochemistryPharmaceutical ScienceRelated derivativesmedicine.disease_causeSettore BIO/19 - Microbiologia Generale01 natural sciencesArticleAnalytical Chemistrylcsh:QD241-441Inhibitory Concentration 5003 medical and health scienceschemistry.chemical_compound2-(2-phenylhydrazinylidene)alkanoic acid derivativeAnti-Infective AgentsBacterial Proteinslcsh:Organic chemistryStaphylococcus epidermidisAmideDrug DiscoveryStaphylococcus epidermidismedicineEnzyme InhibitorsPhysical and Theoretical ChemistryIC50Grambiology010405 organic chemistryChemistryBiofilmSortase AOrganic ChemistryBiofilmAminoacyltransferasesbiology.organism_classificationSettore CHIM/08 - Chimica Farmaceutica2-(2-phenylhydrazinylidene)alkanoic acid derivativesPhenylhydrazines0104 chemical sciencesCysteine Endopeptidases030104 developmental biologyChemistry (miscellaneous)Staphylococcus aureusSortase AFRETMolecular Medicinebiofilms
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Stable spirocyclic neutral radicals: aluminum and gallium boraamidinates

2005

Stable dark red (M = Al) or dark green (M = Ga) neutral radicals {[PhB(μ-NtBu)2]2M}˙ are obtained by the oxidation of their corresponding anions with iodine, and EPR spectra supported by DFT calculations show that the spin density is equally delocalized over all four nitrogen atoms in these spiroconjugated systems. peerReviewed

stable radicalsboraamidinaatitboraamidinatespysyvät radikaalit
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Effects of Temperature and Humidity on Radio Signal Strength in Outdoor Wireless Sensor Networks

2015

Many wireless sensor networks operating outdoors are exposed to changing weather conditions, which may cause severe degradation in system performance. Therefore, it is essential to explore the factors affecting radio link quality in order to mitigate their impact and to adapt to varying conditions. In this paper, we study the effects of temperature and humidity on radio signal strength in outdoor wireless sensor networks. Experimental measurements were performed using Atmel ZigBit 2.4GHz wireless modules, both in summer and wintertime. We employed all the radio channels specified by IEEE 802.15.4 for 2.4GHz ISM frequency band with two transmit power levels. The results show that changes in …

ta113ta213radio signal strengthComputer scienceFrequency bandbusiness.industryRadio Link ProtocolhumiditytemperatureTransmitter power outputTemperature measurementlaw.inventionlawMobile wireless sensor networkElectronic engineeringWirelesslämpötilaTelecommunicationsbusinesswireless sensor networksWireless sensor networkDiversity scheme
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Tube transport of water vapor with condensation and desorption

2013

Attenuation and delay of active tracers in tube transport is an important current problem, but its full explanation is still lacking. To this end a model is introduced, where part of a tracer undergoes condensation and evaporation, treated as a diffusion-type process, in addition to Taylor dispersion. Condensation of water was verified by high-speed imaging, and the model solution fitted the breakthrough curves of laboratory measurements with pulses of water vapor of varying relative humidity. The model provides a transfer function whose performance was verified against field measurements. peerReviewed

ta114010504 meteorology & atmospheric sciencesPhysics and Astronomy (miscellaneous)ChemistryAttenuationTaylor dispersionCondensationAnalytical chemistryEvaporationMechanics01 natural sciences010305 fluids & plasmasDesorption0103 physical sciencesRelative humidityCurrent (fluid)Water vaporPhysics::Atmospheric and Oceanic Physics0105 earth and related environmental sciences
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Experimental and Theoretical Investigations of Tellurium(IV) Diimides and Imidotelluroxanes: X-ray Structures of B(C6F5)3 Adducts of OTe(μ-NtBu)2TeNt…

2005

The hydrolysis of tBuNTe(μ-NtBu)2TeNtBu (1) with 1 or 2 equiv of (C6F5)3B·H2O results in the successive replacement of terminal imido groups by oxo ligands to give the telluroxane-Lewis acid adducts (C6F5)3B·OTe(μ-NtBu)2TeNtBu (2) and [(C6F5)3B·OTe(μ-NtBu)2Te(μ-O)]2 (3), which were characterized by multinuclear NMR spectroscopy and X-ray crystallography. The TeO distance in 2 is 1.870(2) Å. The di-adduct 3 involves the association of four tBuNTeO monomers to give a tetramer in which both terminal TeO groups [d(TeO) = 1.866(3) Å] are coordinated to B(C6F5)3. The central Te2O2 ring in 3 is distinctly unsymmetrical [d(TeO) = 1.912(3) and 2.088(2) Å]. The X-ray structure of (C6F5)3B·NH2tBu (4),…

tellurium(IV) diimidestelluuri(IV) diimiditimidotelluroksaanitimidotelluroxanes
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CCDC 238750: Experimental Crystal Structure Determination

2005

Related Article: M.Ruben, U.Ziener, J.-M.Lehn, V.Ksenofontov, P.Gutlich, G.B.M.Vaughan|2005|Chem.-Eur.J.|11|94|doi:10.1002/chem.200400584

tetrakis(mu~2~-46-bis(22':4'4''-Terpyridine-6'-yl)-2-phenylpyrimidine)-tetra-iron(ii) chloride clathrate heptaperchlorate nitromethane unknown solvate hexahydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 150832: Experimental Crystal Structure Determination

2001

Related Article: E.Breuning, U.Ziener, J.-M.Lehn, E.Wegelius, K.Rissanen|2001|Eur.J.Inorg.Chem.||1515|doi:10.1002/1099-0682(200106)2001:6<1515::AID-EJIC1515>3.0.CO;2-T

tetrakis(mu~2~-46-bis(6'-(6''-Aminopyrimidin-4''-yl)pyrid-2'-yl)-2-phenylpyrimidine)-tetra-cobalt(ii) dichloride tris(hexafluorosilicate) acetonitrile solvate hydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 256886: Experimental Crystal Structure Determination

2005

Related Article: L.H.Uppadine, J.-P.Gisselbrecht, N.Kyritsakas, K.Nattinen, K.Rissanen, J.-M.Lehn|2005|Chem.-Eur.J.|11|2549|doi:10.1002/chem.200401224

tetrakis(mu~2~-4-(2-Pyridylacetylhydrazino)-6-(N-(6-methyl)-2-pyridylformyl-N'-methylhydrazino)-2-phenylpyrimidine)-di-iron(ii)-di-zinc(ii) bis(tetrafluoroborate) unknown solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1979322: Experimental Crystal Structure Determination

2020

Related Article: Noelia Maldonado, Josefina Perles, José Ignacio Martínez, Carlos J. Gómez-García, María-Luisa Marcos, Pilar Amo-Ochoa|2020|Cryst.Growth Des.|20|5097|doi:10.1021/acs.cgd.0c00268

tetrakis{mu-[3-(24-dioxo-34-dihydropyrimidin-1(2H)-yl)propanoato]}-aqua-methanol-di-copper(ii) dihydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 173965: Experimental Crystal Structure Determination

2003

Related Article: G.Marinescu, R.Lecouezec, D.Armentano, G.De Munno, M.Andruh, S.Uriel, R.Llusar, F.Lloret, M.Julve|2002|Inorg.Chim.Acta|336|46|doi:10.1016/S0020-1693(02)00880-0

tetraphenylphosphonium (22'-bipyrimidine)-bis(oxalato)-chromium(iii) monohydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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