Search results for "MILD COGNITIVE IMPAIRMENT"

showing 10 items of 65 documents

Sleep problems and mild cognitive impairment among adults aged ≥50 years from low- and middle-income countries

2021

Background-\ud \ud The limited available literature suggests that sleep problems are linked to an increased risk of mild cognitive impairment (MCI). However, this association has been little studied to date in low-income settings.\ud \ud Objective-\ud \ud To investigate the association between sleep problems and MCI in a large sample of adults from six low-and middle-income countries (LMICs).\ud \ud Design-\ud \ud Cross-sectional.\ud \ud Setting-\ud \ud Study on Global Ageing and Adult Health (SAGE).\ud \ud Subjects-\ud \ud 32,715 individuals aged ≥50 years with preservation in functional abilities [age range 50–114 years; 51.7% females].\ud \ud Methods-\ud \ud MCI was defined using the Nat…

MaleAging*Low- and middle-income countries[SDV]Life Sciences [q-bio]Middle-aged adultsPsychological interventionSleep problemsLogistic regressionBiochemistry0302 clinical medicineEndocrinology*Sleep problemsPrevalence*Mild cognitive impairmentMedicine030212 general & internal medicineCognitive impairmentMorning*Older adultsAged 80 and overLow- and middle-income countriesMiddle AgedSleep in non-human animals3. Good healthOlder adultsFemaleSleep Wake Disorders*DementiaOdds03 medical and health sciencesmental disordersGeneticsHumansDementiaCognitive DysfunctionDeveloping CountriesMolecular BiologyAged*Middle-aged adultsbusiness.industryMild cognitive impairmentCell Biologymedicine.diseaseCross-Sectional StudiesAgeingSmith L. Shin J. I. Jacob L. Carmichael C. López Sánchez G. F. Oh H. Butler L. T. Barnett Y. Pizzol D. Tully M. A. et al. -Sleep problems and mild cognitive impairment among adults aged ≥50 years from low- and middle-income countries.- Experimental gerontology ss.111513 2021DementiaMild cognitive impairment Dementia Sleep problems Low- and middle-income countries Middle-aged adults Older adultsbusiness030217 neurology & neurosurgeryDemographyExperimental Gerontology
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Vascular Risk Factors in Mild Cognitive Impairment Subtypes. Findings from the ReGAl Project.

2007

Abstract Background and Aim: To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study. Methods: Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated. Results: snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MR…

MaleBrainNeuropsychological TestsMagnetic Resonance ImagingRisk AssessmentSeverity of Illness IndexIschemic Attack TransientRisk FactorsSurveys and QuestionnairesCognitive impairment Mild cognitive impairment subtypes Vascular risk factors White-matter lesionsActivities of Daily LivingPrevalenceHumansFemaleSettore MED/26 - NeurologiaAtrophyCognition DisordersAged
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The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population.

2011

Objective: To investigate the symptom of low mood as a predictor of mild cognitive impairment (MCI) and its progression to dementia, taking into account: i) MCI severity, ii) time of assessment, iii) interaction with other factors. Methods: 764 cognitively healthy elderly living in the community, from the Kungsholmen Project. Participants were assessed by direct interview to detect low mood. Subjects were then followed for six years to identify those who developed MCI. People with incident MCI were followed for a further three years to assess progression to dementia. Results: People with low mood at baseline had a 2.7-fold (95% Confidence Interval [CI] 1.9-3.7) increased risk of developing …

MaleDatabases FactualApolipoprotein E4behavioral disciplines and activitiesProdromeCohort Studiesmild cognitive impairmentmental disordersmedicinedepression; epidemiology; mild cognitive impairment; dementiaDementiaHumansCognitive declineAgedSex CharacteristicsMood DisordersCognitive disorderProdromal StageCognitionmedicine.diseaseDiagnostic and Statistical Manual of Mental DisordersPsychiatry and Mental healthMoodData Interpretation StatisticaldepressionDisease ProgressionEducational StatusRegression AnalysisSurgeryepidemiologySettore MED/26 - NeurologiaDementiaFemaleNeurology (clinical)AmnesiaPsychologyCognition DisordersCohort studyClinical psychologyFollow-Up StudiesJournal of neurology, neurosurgery, and psychiatry
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The role of mind theory in patients affected by neurodegenerative disorders and impact on caregiver burden

2020

Abstract Background Theory of Mind (ToM) is defined as the ability to understand mental and emotional state. This ability is assessed also in neurodegenerative disease. Few studies have investigated the impact that social cognition of patients could have on caregiver burden. The aim of this study was to investigate a possible correlation in level of social cognition impairment between patients with different neurodegenerative disorders and their caregivers with possible impact on caregivers burden. Methods we enrolled 48 patients with dementia divided in different groups: Fronto-Temporal Dementia (FTD), Alzheimer Disease (AD), and Mild Cognitive Impairment (MCI) and also the three groups of…

MaleEmotionsTheory of MindDiseaseFronto-temporal dementia03 medical and health sciences0302 clinical medicineSocial cognitionAlzheimer DiseasePhysiology (medical)Theory of mindmental disordersActivities of Daily Livingmedicine80 and overDementiaHumansIn patientCognitive DysfunctionAlzheimer disease; Caregiver; Dementia; Fronto-temporal dementia; Mild cognitive impairment; Theory of mind; Activities of Daily Living; Aged; Aged 80 and over; Alzheimer Disease; Caregivers; Cognitive Dysfunction; Emotions; Female; Frontotemporal Dementia; Humans; Male; Middle Aged; Neurodegenerative Diseases; Theory of MindAgedAged 80 and overbusiness.industryMild cognitive impairmentNeurodegenerative DiseasesGeneral MedicineCaregiver burdenMiddle Agedmedicine.diseaseCaregiverDistressNeurologyCaregivers030220 oncology & carcinogenesisFrontotemporal DementiaSurgeryDementiaFemaleNeurology (clinical)Alzheimer's diseasebusiness030217 neurology & neurosurgeryClinical psychology
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Food Insecurity Is Associated with Mild Cognitive Impairment among Middle-Aged and Older Adults in South Africa:Findings from a Nationally Representa…

2019

There are no studies on the association between food insecurity and mild cognitive impairment (MCI). Thus, cross-sectional, community-based data on individuals aged &ge

MaleEpidemiologyLogistic regressionFood SupplySouth Africa0302 clinical medicineRisk FactorsSurveys and QuestionnairesEpidemiologyPrevalenceMedicine030212 general & internal medicineBRAINCognitive impairmentRISK2. Zero hungerNutrition and DieteticsDEMENTIAConfounding1. No povertyMiddle AgedDEPRESSIONPREVALENCEALZHEIMERS-DISEASEFood insecurityFemalelcsh:Nutrition. Foods and food supplyLife Sciences & Biomedicinemedicine.medical_specialtyMedicinaPERCEIVED STRESSlcsh:TX341-641ArticleWorld healthOdds03 medical and health sciencesPEOPLEEnvironmental healthHumansDementiaCognitive DysfunctionAgedDECLINEScience & TechnologyNutrition & DieteticsFood insecuritybusiness.industryMild cognitive impairmentmedicine.diseaseCross-Sectional StudiesLogistic ModelsPHYSICAL-ACTIVITYMultivariate Analysisbusiness030217 neurology & neurosurgeryFood Science
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The association between objective vision impairment and mild cognitive impairment among older adults in low- and middle-income countries

2021

Aim: The association between visual impairment and mild cognitive impairment (MCI) has not been investigated to date. Thus, we assessed this association among older adults from six low- and middle-income countries (LMICs) (China, India, Ghana, Mexico, Russia, and South Africa) using nationally representative datasets. Methods: Cross-sectional, community-based data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. Visual acuity was measured using the tumbling ElogMAR chart, and vision impairment (at distance and near) was defined as visual acuity worse than 6/18 (0.48 logMAR) in the better-seeing eye. The definition of MCI was based on the National Institute on Aging…

MaleGerontologyChinaAgingmedicine.medical_specialtyVisual acuitygenetic structuresEpidemiology[SDV]Life Sciences [q-bio]Visual impairmentVision impairmentLogistic regressionOdds03 medical and health sciences0302 clinical medicineEpidemiologyPrevalenceHumansMedicineDementiaCognitive Dysfunction030212 general & internal medicineAssociation (psychology)Developing CountriesAgedLow- and middle-income countriesbusiness.industryMild cognitive impairmentmedicine.diseaseeye diseasesSmith L. Shin J. I. Jacob L. López-Sánchez G. F. Oh H. Barnett Y. Pardhan S. Butler L. Soysal P. Veronese N. et al. -The association between objective vision impairment and mild cognitive impairment among older adults in low- and middle-income countries.- Aging clinical and experimental research 2021Vision impairment Mild cognitive impairment Older adults Low- and middle-income countries EpidemiologyCross-Sectional StudiesAgeingOlder adultsFemaleGeriatrics and Gerontologymedicine.symptombusiness030217 neurology & neurosurgeryAging Clinical and Experimental Research
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Heterogeneity in Risk Factors for Cognitive Impairment, No Dementia: Population-Based Longitudinal Study From the Kungsholmen Project

2006

OBJECTIVES: The objectives of this study were to investigate the relation of vascular, neuropsychiatric, social, and frailty-related factors with "Cognitive impairment, no dementia" (CIND) and to verify their effect independently of future progression to Alzheimer disease (AD). METHODS: Seven hundred eighteen subjects aged 75+ years who attended baseline, 3- and 6-year follow-up examinations of the Kungsholmen Project, a Swedish prospective cohort study, were studied. CIND was defined according to the performance on the Mini-Mental State Examination. Potential risk factors were collected at baseline and clustered according to four research hypotheses (frailty, vascular, neuropsychiatric, an…

MaleLongitudinal studyPsychosisPopulationAlzheimer DiseaseRisk FactorsActivities of Daily Livingmental disordersmedicineHumansDementiaeducationProspective cohort studyAgedProportional Hazards ModelsAged 80 and overSwedenPolypharmacyeducation.field_of_studyHip fractureHip FracturesMild cognitive impairment Alzheimer disease hip fracture polypharmacy psychosismedicine.diseasePsychiatry and Mental healthPsychotic DisordersDisease ProgressionPolypharmacyFemaleSettore MED/26 - NeurologiaGeriatrics and GerontologyAlzheimer's diseaseCognition DisordersPsychologyFollow-Up StudiesClinical psychologyThe American Journal of Geriatric Psychiatry
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''Motor Resonance Mechanisms Are Preserved In Alzheimer's Disease Patients''

2012

Bisio, A. | Casteran, M. | Ballay, Y. | Manckoundia, P. | Mourey, F. | Pozzo, T.; International audience; ''This study aimed to better characterize the sensorimotor mechanisms underlying motor resonance, namely the relationship between motion perception and movement production in patients suffering from Alzheimer's disease (AD). This work first gives a kinematic description of AD patients' upper limb movements, then it presents a simple paradigm in which a dot with different velocities is moved in front of the participant who is instructed to point to its final position when it stopped. AD patients' actions, as well as healthy elderly participants, were similarly influenced by the dot veloc…

MaleMILD COGNITIVE IMPAIRMENTData InterpretationInhibition (Psychology)DiseaseNeuropsychological TestsHUMAN AUTONOMYExecutive FunctionCognition80 and overAged 80 and overMovement observation-executionGeneral NeuroscienceMIRROR NEURONSCognitionStatisticalAction-perception matchingAction-perception matching; Ageing; Automatic imitation; Dementia; Movement observation-execution; Aged; Aged 80 and over; Alzheimer Disease; Arm; Biomechanical Phenomena; Cognition; Data Interpretation Statistical; Executive Function; Female; Humans; Inhibition (Psychology); Linear Models; Male; Movement; Neuropsychological Tests; Photic Stimulation; Psychomotor Performance; Neuroscience (all)Biomechanical PhenomenaInhibition PsychologicalSOCIAL COGNITIONData Interpretation Statistical[ SCCO.NEUR ] Cognitive science/NeuroscienceArmFemaleAlzheimer's diseasePsychologyMovementStimulus (physiology)Alzheimer DiseaseCOLOR-WORD TESTmedicineHumansDementiaREACTION-TIME''Motion perceptionREACTION-TIMENEURAL MECHANISMSMotor resonanceAgedNeuroscience (all)Healthy elderlyPOINTING MOVEMENTSmedicine.diseaseFRONTAL LOBESVISUOMOTOR INTEGRATIONAgeing''MILD COGNITIVE IMPAIRMENTLinear ModelsDementiaNeuroscienceAutomatic imitationPhotic StimulationPsychomotor Performance
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Lymphocytic Mitochondrial Aconitase Activity is Reduced in Alzheimer's Disease and Mild Cognitive Impairment

2015

Background: Specific mechanisms behind the role of oxidative/nitrosative stress and mitochondrial dysfunction in Alzheimer's disease (AD) pathogenesis remain elusive. Mitochondrial aconitase (ACO2) is a Krebs cycle enzyme sensitive to free radicalmediated damage. Objective: We assessed activity and expression of ACO2 extracted from blood lymphocytes of subjects with AD, mild cognitive impairment (MCI), older adults with normal cognition (OCN, age >= 65 years), and younger adults with normal cognition (YCN, age < 65 years). Plasma levels and activities of antioxidants were also measured. Methods: Blood samples were collected from 28 subjects with AD, 22 with MCI, 21 OCN, and 19 YCN. ACO2 act…

MalePathologyantioxidantAntioxidantmedicine.medical_treatmentLymphocyteMitochondrionmedicine.disease_causePolymerase Chain ReactionPathogenesisVitamin Eoxidative stressLymphocytesaconitase (aconitate hydratase)Aconitate Hydratasereactive oxygen speciesGeneral NeuroscienceACO2General MedicineAlzheimer's diseasemitochondriaPsychiatry and Mental healthClinical Psychologyantioxidantsmedicine.anatomical_structureDisease ProgressionSettore MED/26 - NeurologiaFemaleAlzheimer diseaseAlzheimer's diseaseAzheimer diseasereactive nitrogen speciemedicine.medical_specialtyaconitase (aconitate hydratase); Alzheimer disease; antioxidants; free radicals; lymphocyte; mild cognitive impairment; mitochondria; oxidative stress; reactive nitrogen species; reactive oxygen speciesBlotting Westernfree radicalslymphocytemild cognitive impairmentInternal medicinemedicineHumansCognitive DysfunctionRNA MessengerAgedfree radicaloxidative strebusiness.industryVitamin EAconitasimedicine.diseasereactive nitrogen speciesEndocrinologyGeriatrics and GerontologyAlzheimer's disease; Aconitasi; oxidative stress; Aconitase (aconitate hydratase) Azheimer disease antioxidants free radicals lymphocyte mild cognitive impairment mitochondria oxidative stress reactive nitrogen species reactive oxygen speciesMental Status SchedulebusinessBiomarkersOxidative stressJournal of Alzheimer's Disease
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Chronic physical conditions, multimorbidity, and mild cognitive impairment in low- and middle-Income countries

2018

BACKGROUND/OBJECTIVES: Chronic physical conditions and multimorbidity may be modifiable risk factors for dementia. However, data from low- and middle-income countries (LMICs) are lacking. This study thus assessed the association of chronic physical conditions and multimorbidity with mild cognitive impairment (MCI) in LMICs. DESIGN: Nationally representative, cross-sectional, community-based. SETTING: Six countries which participated in the World Health Organization’s Study on Global Ageing and Adult Health. PARTICIPANTS: 32,715 adults aged ≥50 years [mean (SD) age 62.1 (15.6) years; 51.7% females]. MEASUREMENTS: The definition of MCI was based on the recommendations of the National Institut…

Malechronic physical conditionChronic physical conditions; Low- and middle-income countries; Mild cognitive impairment; Multimorbidity; Geriatrics and GerontologyGlobal HealthArticlePrevalenceHumansCognitive DysfunctionDeveloping CountriesPovertyAgedAged 80 and overLow- and middle-income countriesMild cognitive impairmentMultimorbidityMiddle Aged*low- and middle-income countries*chronic physical conditionsChronic physical conditionsCross-Sectional Studies*mild cognitive impairmentChronic DiseaseFemale*multimorbidityGeriatrics and GerontologyDisfunção Cognitiva
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