Search results for "MILD"

showing 10 items of 193 documents

<i>GJB2</i> Mutations and Genotype-Phenotype Correlation in 335 Patients from Germany with Nonsyndromic Sensorineural Hearing Loss: Evide…

2009

We report on 335 patients (319 families) with mild-to-profound nonsyndromic sensorineural hearing loss. We identified 178 mutated <i>GJB2</i> alleles representing 29 different sequence changes (including 3 novel mutations: Q7P, N14D, H100Q), and 2 alleles with the deletion del(GJB6-D13S1830) of the <i>GJB6</i> gene. Eleven <i>GJB2</i> mutations (119 mutated alleles) were truncating (T), and 18 mutations (59 alleles) were nontruncating (NT). Biallelic <i>GJB2</i> mutations were found in 71 patients (21.2%; 67 families; 25 different genotypes). Audiograms of 62 patients (56 families) with biallelic <i>GJB2</i> mutations typically ind…

MaleMild hearing impairmentPathologymedicine.medical_specialtyGenotypePhysiologyHearing lossHearing Loss SensorineuralGenes Recessivemedicine.disease_causePolymerase Chain ReactionConnexinsSpeech and HearingAudiometryGene FrequencyGermanyGenotypeotorhinolaryngologic diseasesmedicineHumansAlleleAllele frequencyAllelesGenetic Association StudiesGeneticsMutationbiologybusiness.industrymedicine.diseaseSensory SystemsConnexin 26PhenotypeOtorhinolaryngologyMutationbiology.proteinFemaleSensorineural hearing lossmedicine.symptombusinessGJB6Audiology and Neurotology
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Mild Hypothermia Has No Long-Term Impact on Postischemic Neurogenesis in Rats

2009

Postischemic improvement of functional outcome by therapeutic hypothermia may be related to cerebral regeneration by postischemic neurogenesis. We investigated whether mild peri-ischemic hypothermia leads to a long-term increase in postischemic neurogenesis.Seventy male sevoflurane-anesthetized Sprague Dawley rats were randomly assigned to the following treatment groups: normothermic ischemia, intraischemic hypothermia, and postischemic hypothermia with corresponding sham-operated controls. Fifteen naïve rats were investigated as reference for natural neurogenesis. Forebrain ischemia was induced by bilateral common carotid artery occlusion and hemorrhagic hypotension. In normothermic groups…

MaleMild hypothermiaTime FactorsNeurogenesisIschemiaSeverity of Illness IndexBrain IschemiaRats Sprague-DawleyProsencephalonHypothermia InducedmedicineAnimalsCell ProliferationNeuronsbusiness.industryNeurogenesisHypothermiamedicine.diseaseRatsSprague dawleyDisease Models AnimalAnesthesiology and Pain MedicineAnesthesiaDentate GyrusNerve Degenerationmedicine.symptombusinessAnesthesia & Analgesia
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Neuroprotective Properties of Mildronate, a Small Molecule, in a Rat Model of Parkinson’s Disease

2010

Previously, we have found that mildronate [3-(2,2,2-trimethylhydrazinium) propionate dihydrate], a small molecule with charged nitrogen and oxygen atoms, protects mitochondrial metabolism that is altered by inhibitors of complex I and has neuroprotective effects in an azidothymidine-neurotoxicity mouse model. In the present study, we investigated the effects of mildronate in a rat model of Parkinson’s disease (PD) that was generated via a unilateral intrastriatal injection of the neurotoxin 6-hydroxydopamine (6‑OHDA). We assessed the expression of cell biomarkers that are involved in signaling cascades and provide neural and glial integration: the neuronal marker TH (tyrosine hydroxylase); …

MaleNitric Oxide Synthase Type IIlcsh:ChemistryUbiquitinNeurotoxinlcsh:QH301-705.5Receptor Notch3SpectroscopyNeuronsReceptors NotchbiologyGlial fibrillary acidic proteinMicrofilament ProteinsGeneral MedicineComputer Science ApplicationsCell biologySubstantia NigraNitric oxide synthaseNeuroprotective Agentsmedicine.anatomical_structureBiochemistryNeurogliaNeurogliaMethylhydrazinesneuroimmunological biomarkersTyrosine 3-Monooxygenasesmall moleculeSubstantia nigraParkinson’s disease; 6-OHDA model; neuroimmunological biomarkers; mildronate; small moleculeNeuroprotectionArticleCatalysisInorganic ChemistryGlial Fibrillary Acidic ProteinmedicineAnimalsParkinson Disease SecondaryRats WistarPhysical and Theoretical ChemistryOxidopamineMolecular BiologyTyrosine hydroxylase6-OHDA modelCalcium-Binding ProteinsmildronateOrganic ChemistryCorpus StriatumRatslcsh:Biology (General)lcsh:QD1-999nervous systemParkinson’s diseasebiology.proteinBiomarkersInternational Journal of Molecular Sciences
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Lymphocytic Mitochondrial Aconitase Activity is Reduced in Alzheimer's Disease and Mild Cognitive Impairment

2015

Background: Specific mechanisms behind the role of oxidative/nitrosative stress and mitochondrial dysfunction in Alzheimer's disease (AD) pathogenesis remain elusive. Mitochondrial aconitase (ACO2) is a Krebs cycle enzyme sensitive to free radicalmediated damage. Objective: We assessed activity and expression of ACO2 extracted from blood lymphocytes of subjects with AD, mild cognitive impairment (MCI), older adults with normal cognition (OCN, age >= 65 years), and younger adults with normal cognition (YCN, age < 65 years). Plasma levels and activities of antioxidants were also measured. Methods: Blood samples were collected from 28 subjects with AD, 22 with MCI, 21 OCN, and 19 YCN. ACO2 act…

MalePathologyantioxidantAntioxidantmedicine.medical_treatmentLymphocyteMitochondrionmedicine.disease_causePolymerase Chain ReactionPathogenesisVitamin Eoxidative stressLymphocytesaconitase (aconitate hydratase)Aconitate Hydratasereactive oxygen speciesGeneral NeuroscienceACO2General MedicineAlzheimer's diseasemitochondriaPsychiatry and Mental healthClinical Psychologyantioxidantsmedicine.anatomical_structureDisease ProgressionSettore MED/26 - NeurologiaFemaleAlzheimer diseaseAlzheimer's diseaseAzheimer diseasereactive nitrogen speciemedicine.medical_specialtyaconitase (aconitate hydratase); Alzheimer disease; antioxidants; free radicals; lymphocyte; mild cognitive impairment; mitochondria; oxidative stress; reactive nitrogen species; reactive oxygen speciesBlotting Westernfree radicalslymphocytemild cognitive impairmentInternal medicinemedicineHumansCognitive DysfunctionRNA MessengerAgedfree radicaloxidative strebusiness.industryVitamin EAconitasimedicine.diseasereactive nitrogen speciesEndocrinologyGeriatrics and GerontologyAlzheimer's disease; Aconitasi; oxidative stress; Aconitase (aconitate hydratase) Azheimer disease antioxidants free radicals lymphocyte mild cognitive impairment mitochondria oxidative stress reactive nitrogen species reactive oxygen speciesMental Status SchedulebusinessBiomarkersOxidative stressJournal of Alzheimer's Disease
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The characteristics of different diagnostic tests in adult mild asthmatic patients: Comparison with patients with asthma-like symptoms by gastro-oeso…

2007

SummaryBackgroundDiagnosing asthma cannot be always easy. It is important to consider the validity of the diagnostic tests, and/or how much more commonly they are positive in patients with asthma compared to healthy subjects and, particularly, to patients with asthma-like symptoms.ObjectiveTo evaluate the validity of diagnostic tests for asthma, in terms of sensitivity, specificity, positive and negative predictive values, in patients with bronchial asthma compared to patients affected by gastro-oesophageal reflux disease (GERD) with asthma-like symptoms, and healthy control subjects without asthma and gastro-oesophageal reflux (GER).DesignSingle-center, cross-sectional, observational study…

MaleVital capacitySettore MED/09 - Medicina Internaadult mild asthmatic patientVital CapacityGastroenterologygastro-oesophageal reflux.Bronchoconstrictor AgentsLeukocyte CountSensitivityimmune system diseasesForced Expiratory VolumeMethacholine ChlorideEosinophil cationic proteinRespiratory diseaseMiddle Agedrespiratory systemmedicine.anatomical_structureDiagnostic testsGastroesophageal RefluxSpecificityFemalemedicine.drugcirculatory and respiratory physiologyAdultPulmonary and Respiratory Medicinemedicine.medical_specialtyBronchial Provocation TestsDiagnosis DifferentialFEV1/FVC ratioGastro-oesophageal reflux diseaseInternal medicinemedicineHumansAsthmabusiness.industryEosinophil Cationic ProteinSputumadult mild asthmatic patients; gastro-oesophageal reflux.Eosinophilmedicine.diseaseAsthmaSurgeryrespiratory tract diseasesEosinophilsSpirometryGERDMethacholineEpidemiologic MethodsbusinessBiomarkersGastro-oesophageal refluxRespiratory Medicine
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Two peculiar types of enchondromatosis.

1978

On the basis of 3 personal observations and of 6 cases from the literature, two peculiar types of enchondromatosis are delineated: 1. Enchondromatosis with generalized, irregular vertebral lesions, and 2. Generalized enchondromatosis with mild platyspondyly.

Malebusiness.industryAnatomymedicine.diseaseOsteochondrodysplasiasBone and BonesRadiographyChild PreschoolPediatrics Perinatology and Child HealthEnchondromatosismedicineHumansRadiology Nuclear Medicine and imagingMild platyspondylybusinessChildOllier diseasePediatric radiology
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Chronic physical conditions, multimorbidity, and mild cognitive impairment in low- and middle-Income countries

2018

BACKGROUND/OBJECTIVES: Chronic physical conditions and multimorbidity may be modifiable risk factors for dementia. However, data from low- and middle-income countries (LMICs) are lacking. This study thus assessed the association of chronic physical conditions and multimorbidity with mild cognitive impairment (MCI) in LMICs. DESIGN: Nationally representative, cross-sectional, community-based. SETTING: Six countries which participated in the World Health Organization’s Study on Global Ageing and Adult Health. PARTICIPANTS: 32,715 adults aged ≥50 years [mean (SD) age 62.1 (15.6) years; 51.7% females]. MEASUREMENTS: The definition of MCI was based on the recommendations of the National Institut…

Malechronic physical conditionChronic physical conditions; Low- and middle-income countries; Mild cognitive impairment; Multimorbidity; Geriatrics and GerontologyGlobal HealthArticlePrevalenceHumansCognitive DysfunctionDeveloping CountriesPovertyAgedAged 80 and overLow- and middle-income countriesMild cognitive impairmentMultimorbidityMiddle Aged*low- and middle-income countries*chronic physical conditionsChronic physical conditionsCross-Sectional Studies*mild cognitive impairmentChronic DiseaseFemale*multimorbidityGeriatrics and GerontologyDisfunção Cognitiva
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The instruments used by the Italian centres for cognitive disorders and dementia to diagnose mild cognitive impairment (MCI).

2018

Aims: The purpose of this study was to examine the tools used in Italy to diagnose mild cognitive impairment (MCI). Methods: In collaboration with the Luigi Amaducci Research Consortium, the Italian Network of Alzheimer Evaluation Units prepared a questionnaire to describe how MCI is diagnosed in the Italian Centres for cognitive disorders and dementia (CCDD). Results: Most of the ninety-two CCDDs participating in the survey were located in hospitals (54.7%); large percentages were coordinated by neurologists (50.8%) and geriatricians (44.6%). Almost all (98.5%) used the Mini Mental State Examination to diagnose MCI; the Clock Drawing Test was also frequently used (83.9%). Other neuropsycho…

Malemedicine.medical_specialtyAgingDiagnosis toolStandardized testItalian centres for cognitive disorders and dementia03 medical and health sciences0302 clinical medicineSurveys and Questionnairesmental disordersmedicineDementiaHumansCognitive Dysfunction030212 general & internal medicineMedical diagnosisMild cognitive impairment (MCI)Geriatric AssessmentAgedAged 80 and overMini–Mental State Examinationmedicine.diagnostic_testbusiness.industryNeuropsychologyMild cognitive impairmentCognitionmedicine.diseaseMental Status and Dementia TestsItalyPhysical therapySettore MED/26 - NeurologiaDementiaFemaleGeriatrics and GerontologybusinessClock drawing test030217 neurology & neurosurgeryAging clinical and experimental research
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Effects of bilingualism on white matter atrophy in mild cognitive impairment: a diffusion tensor imaging study

2020

Background and purpose Previous investigations show that bilinguals exhibit the first symptoms of dementia 4-5 years later than monolinguals. Therefore, bilingualism has been proposed as a cognitive reserve mechanism. Recent studies have advanced towards an understanding of the brain mechanisms underlying bilingualism's protection against dementia, but none of them deals with white matter (WM) diffusion. Methods In this study, the topic was investigated by measuring WM integrity in a sample of 35 bilinguals and 53 passive bilinguals with mild cognitive impairment. Results No significant differences were found between the groups in cognitive level, education, age or sex. However, bilinguals …

Malemedicine.medical_specialtyBilingualismMildcognitive impairmentMultilingualismAudiologyWhite matter03 medical and health sciences0302 clinical medicineCognitive ReserveFractional anisotropymedicineHumansDementiaCingulum (brain)Cognitive Dysfunction030212 general & internal medicineAgedCognitive reservebusiness.industryFornixBrainmedicine.diseasebilingualism diffusion tensor imaging mild cognitive impairmentWhite MatterDiffusiontensor imagingDiffusion Tensor ImagingBoston Naming Testmedicine.anatomical_structureNeurologyAnisotropyFemaleNeurology (clinical)AtrophyNerve Netbusiness030217 neurology & neurosurgeryDiffusion MRIEuropean Journal of Neurology
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Verbal Fluency in Mild Alzheimer's Disease: Transcranial Direct Current Stimulation over the Dorsolateral Prefrontal Cortex

2021

Background: Recent studies showed that in healthy controls and in aphasic patients, inhibitory trains of repetitive transcranial magnetic stimulation (rTMS) over the right prefrontal cortex can improve phonemic fluency performance, while anodal transcranial direct current stimulation (tDCS) over the left prefrontal cortex can improve performance in naming and semantic fluency tasks. Objective: This study aimed at investigating the effects of cathodal tDCS over the left or the right dorsolateral prefrontal cortex (DLPFC) on verbal fluency tasks (VFT) in patients with mild Alzheimer’s disease (AD). Methods: Forty mild AD patients participated in the study (mean age 73.17±5.61 years). All part…

Malemedicine.medical_specialtyBrain activity and meditationmedicine.medical_treatmentPrefrontal CortexDiseaseAudiologyNeuropsychological Testsbehavioral disciplines and activities050105 experimental psychologytranscranial Direct Current Stimulation03 medical and health sciencesFluency0302 clinical medicineCognitionAlzheimer DiseasemedicineVerbal fluency testHumansSpeech0501 psychology and cognitive sciencesDorsolateral Prefrontal Cortex.AgedTranscranial direct-current stimulationSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicabusiness.industryGeneral Neuroscience05 social sciencesverbal fluencyCognitionGeneral MedicineDorsolateral prefrontal cortexTranscranial magnetic stimulationPsychiatry and Mental healthClinical Psychologymedicine.anatomical_structureTreatment OutcomeFemaleMild Alzheimer’s DiseaseGeriatrics and Gerontologybusiness030217 neurology & neurosurgery
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