Search results for "MODULATION"
showing 10 items of 948 documents
Regulatory T Cells and IL-10 Independently Counterregulate Cytotoxic T Lymphocyte Responses Induced by Transcutaneous Immunization
2011
Background: The imidazoquinoline derivate imiquimod induces inflammatory responses and protection against transplanted tumors when applied to the skin in combination with a cognate peptide epitope (transcutaneous immunization, TCI). Here we investigated the role of regulatory T cells (Treg) and the suppressive cytokine IL-10 in restricting TCI-induced cytotoxic T lymphocyte (CTL) responses. Methodology/Principal Findings: TCI was performed with an ointment containing the TLR7 agonist imiquimod and a CTL epitope was applied to the depilated back skin of C57BL/6 mice. Using specific antibodies and FoxP3-diphteria toxin receptor transgenic (DEREG) mice, we interrogated inhibiting factors after…
Optical spectra beyond the amplifier bandwidth limitation in dispersion-managed mode-locked fiber lasers
2011
We investigate the intracavity pulse dynamics inside dispersionmanaged mode-locked fiber lasers, and show numerically that for a relatively wide range of parameters, pulse compression dynamics in the passive anomalous fiber can be accompanied by a significant enhancement of the spectral width by a factor close to 3. Varying the average cavity dispersion also reveals chaotic dynamics for certain dispersion ranges. The impact of the implementation of an optical output port to tap optimal pulse features is discussed. © 2011 Optical Society of America.
Multipactor RF Breakdown in Coaxial Transmission Lines With Digitally Modulated Signals
2016
The aim of this paper is the study of the RF multipactor breakdown in coaxial transmission lines excited by a single carrier with a digitally modulated signal. Employing an in-house developed code, numerical simulations are performed to determine the RF multipactor voltage threshold for several digitally modulated signals under different modulations schemes: quadrature phase-shift keying, 16-quadrature amplitude modulation, 16-amplitude and phase-shift keying, and 32-amplitude and phase-shift keying. Moreover, a coarse method based on the envelope integration to determine the RF multipactor voltage threshold when involving arbitrary digital modulations is also presented. These results are a…
Modulation of current-time traces by two-pore arrangements of polyimide nanofluidic diodes
2019
Liquid state arrangements of two polymeric membranes with single conical nanopores constitute nanofluidic diodes that allow a rich electrical functionality based on the modulation of individual conductances in aqueous electrolyte solutions. In particular, the prescribed sequences of current-time traces can be obtained by preprogramed switching between series and parallel pore connection arrangements. Hybrid nanopore-solid-state circuits are also possible. The basic applied physics of the nanofluidic diode arrangements can be understood from simple circuit theory concepts and should be of widespread interest to sensing and actuating procedures, controlled release dispensers, and energy conve…
Photoswitchable Micro-Supercapacitor Based on a Diarylethene-Graphene Composite Film
2017
Stimuli-responsive micro-supercapacitors (MSCs) controlled by external stimuli can enable a wide range of applications for future on-chip energy storage. Here, we report on a photoswitchable MSC based on a diarylethene-graphene composite film. The microdevice delivers an outstanding and reversible capacitance modulation of up to 20%, demonstrating a prototype photoswitchable MSC. Terahertz spectroscopy indicates that the photoswitching of the capacitance is enabled by the reversible tuning of interfacial charge injection into diarylethene molecular orbitals, as a consequence of charge transfer at the diarylethene-graphene interface upon light modulation.
Editorial: Neuromodulatory ascending systems: Their influence at the microscopic and macroscopic levels
2022
Brain activity and behavior are constantly changing (Puig et al., 2014; Disney, 2021). Recent studies in both animal models and humans have revealed that such variations are not random in nature but controlled through slow-acting neuromodulatory systems...
Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems.
2015
Microglia are brain macrophages that emerge from early erythro-myeloid precursors in the embryonic yolk sac and migrate to the brain mesenchyme before the blood brain barrier is formed. They seed the brain, and proliferate until they have formed a grid-like distribution in the central nervous system that is maintained throughout lifespan. The mechanisms through which these embryonic-derived cells contribute to microglia homoeostasis at steady state and upon inflammation are still not entirely clear. Here we review recent studies that provided insight into the contribution of embryonically-derived microglia and of adult 'microglia-like' cells derived from monocytes during inflammation. We ex…
Non-equilibrium monitoring using self-phase modulation
2006
2 pages; International audience; Laser induced self-phase modulation phenomenon is observed in a blackberry juice using moderate beam intensity. The sample content qualities can be quantified by measuring optical parameters, we show the possibility to use the nonlinear in an on-line homogeneity monitoring.
Multiscaling and the classification of continuous phase transitions
1992
Multiscaling of the free energy is obtained by generalizing the classification of phase transitions proposed by Ehrenfest. The free energy is found to obey a new generalized scaling form which contains as special cases standard and multiscaling forms. The results are obtained by analytic continuation from the classification scheme of Ehrenfest.
Scaling guidelines of a soliton-based power limiter for 2R-optical regeneration applications
2010
International audience; In this work, we report scaling rules for the design of an all-fibered soliton-based power limiter for reamplification and reshaping (2R) regeneration process. In particular, we propose general guidelines to fix the optimum fiber length and initial power of the regenerator. We quantitatively point out the optical power limiting effect of the device enabling a significant reduction of the amplitude jitter of a degraded signal. Influence of the initial level of amplitude jitter is discussed and the results are compared with a self-phase modulation-based configuration working in the normal dispersion regime. Realistic numerical simulations in the context of 160 Gbit/s s…