Search results for "MR"
showing 10 items of 3001 documents
Inside Cover: Hydrogen-Bonded Open-Framework with Pyridyl-Decorated Channels: Straightforward Preparation and Insight into Its Affinity for Acidic Mo…
2017
International audience; A hydrogen-bonded open framework with pores decorated by pyridyl groups was constructed by off-charge-stoichiometry assembly of protonated tetrakis(4-pyridyloxymethyl)methane and [Al(oxalate)(3)](3-), which are the H-bond donor and acceptor of ionic H-bond interactions, respectively. This supramolecular porous architecture (SPA-2) has 1nm-large pores interconnected in 3D with large solvent-accessible void (53%). It demonstrated remarkable affinity for acidic organic molecules in solution, which was investigated by means of various carboxylic acids including larger drug molecules. Competing sorption between acetic acid and its halogenated homologues evidenced good sel…
Interaktīvu datorprogrammu izmantošana matemātikas metodikā 7. klasē
2021
Diplomdarbs “Interaktīvu datorprogrammu izmantošana matemātikas metodikā 7. klasē” piedāvā ieskatu praktiskā pētījumā/pedagoģiskā eksperimentā, kā padarīt matemātikas mācīšanu 7. klasē pēc iespējas jēgpilnāku, balstoties uz tehnoloģiju iespējām. Darbā tiek analizēta interaktīvu datorprogrammu efektivitāte/lietojamība matemātisku problēmu risināšanā, sakarību atklāšanā un apkopoti metodiski ieteikumi matemātikas skolotājiem digitālu rīku izmantošanai 7. klases matemātikas stundās. Darbā piedāvāts ieskats, kā skolēniem efektīvāk mācīt matemātikas problēmrisināšanas prasmes, diferencējot IT programmas vizualizācijai un vienlaikus paaugstinot skolēnu mācību motivāciju, kā arī praktiski pārbaudī…
Cough is dangerous : neural correlates of implicit body symptoms associations
2016
The negative interpretation of body sensations (e.g., as sign of a severe illness) is a crucial cognitive process in pathological health anxiety (HA). However, little is known about the nature and the degree of automaticity of this interpretation bias. We applied an implicit association test (IAT) in 20 subjects during functional magnetic resonance imaging (fMRI) to investigate behavioral and neural correlates of implicit attitudes towards symptom words. On the behavioral level, body symptom words elicited strong negative implicit association effects, as indexed by slowed reaction times when symptom words were paired with the attribute harmless (incongruent condition) relative to a control …
Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology
2020
Amyloids are fibrillar protein aggregates associated with diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), type II diabetes and Creutzfeldt–Jakob disease. The process of amyloid polymerization involves three pathological protein transformations; from natively folded conformation to the cross-β conformation, from biophysically soluble to insoluble, and from biologically functional to non-functional. While amyloids share a similar cross-β conformation, the biophysical transformation can either take place spontaneously via a homogeneous nucleation mechanism (HON) or catalytically on an exogenous surface via a heterogeneous nucleation mechanism (HEN). Here, we postulate that…
Melanokortīna otrā tipa receptora un tā palīgproteīna ekspresija rauga Pichia Pastoris ekspresijas sistēmā
2015
Darba ietvaros tika izveidots pPIC9K- MC2R-T4L ekspresijas konstrukts, kas tika ekspresēts P.Pastoris sistēmā. Western blot analīze uzrādīja nepieciešamās molekulmasas zonu. MC2R-T4L izdevās attīrīt uz His- un Ha-tag afinitātes kolonnām. Lai noteiktu funkcionāla MC2R struktūru, to nepiecieciešams ekspresēt kompleksā ar MRAP, tādēļ tika izveidoti vairāki MC2-MRAP konstrukti, ko tālāk izmantot proteīna ekspresijai P. Pastoris šūnās. To aktivitāte tika pārbaudīta zīdītāju šūnu līnijās nosakot cAMP daudzuma izmaiņas pēc stimulācijas ar ACTH (1-24). Iegūtie rezultāti bija nestabili, tādēļ tālākajos pētījumos tiks veikta radioaktīvā ACTH saistīšanas mērījumus. Darbs tika veikts no 2013.gada jūnij…
Isolement et caractérisation de saponosides extraits de deux plantes médicinales : Cyclamen africanum, Zygophyllum cornutum et évalution de leur acti…
2014
The appearance of several diseases, such as cancer, diabetes, high blood pressure and spread of infections mutagenic virus type can be linked to the quality and lifestyle that we lead today. Indeed, several studies on the factors triggering these so-called "morbid" long-or short-term illnesses are related to stress and quality of food consumed, whether of plant and animal origin. These diseases are becoming a common occurrence, they affect different races and all classes of society. According ethnobotanical research, naturally occurring substances, allowed civilizations to survive deadly diseases. For example, we thus find references to periods of malarial fever in China and one of the symp…
Pankin pääomarakenne ja varainhankinta nykyisessä ja tulevassa pankkisääntelyssä
2017
Tämä tutkielma kokoaa yhteen pankkeja nykyisin velvoittavat pääomien määrään ja maksuvalmiuteen sekä rahoitukseen liittyvät sääntelyt. Tutkielman tavoitteena on saada vastaus kysymykseen: Miten pankin tulee huomioida pankkisääntely pääoman ja varainhankinnan rakenteessaan? Tutkielman alussa esitellään pankkitoimintaa yleisesti ja siihen liittyviä optimointiongelmia. Pankkien kannalta optimaalinen pääomarakenne poikkeaa sosiaalisesti optimaalisesta ja tätä varten pankkisääntelyä tarvitaan. Optimaalisimman tason määrittely on haastavaa, mutta sen on arvioitu olevan 15-20 % tasolla. Pääomarakenteella on vaikutusta pankin tuottavuuteen ja menestymisen mahdollisuuksiin. Pankkeja voidaan säännell…
Nanopartículas de oro: procesos fotoinducidos y estudios de transferencia de fase
2013
Las propiedades físicas y químicas de las nanopartículas de oro (AuNPs), tales como la interacción con la luz, solubilidad, catálisis, etc. dependen de varios factores: El tamaño y la forma: la interacción de las AuNPs con la luz depende mucho de sus dimensiones físicas. Estos parámetros son cruciales para la aplicación de estos nanomateriales. El ligando puede modificar las propiedades ópticas, las propiedades químicas, la estabilidad y la solubilidad de las AuNPs. Uno de los objetivos de esta tesis es optimizar la modificación controlada del tamaño/forma de AuNPs estabilizadas con tioles utilizando luz, ya sea en presencia o en ausencia de un fotosensibilizador. El otro objetivo, es e…
An Endemic Plant of the Mediterranean Area: Phytochemical Characterization of Strawberry Tree (Arbutus unedo L.) Fruits Extracts at Different Ripenin…
2022
This work focused on the extraction, quantification, and characterization of bioactive compounds of Arbutus unedo L. fruits, comparing the results obtained from the different ripening states. Extractions were performed by different methods (such as maceration extraction and ultrasonic extraction) and food grade solvents (aqueous and hydroalcoholic solvents) in each of the all ripening states (four states considered, associated with four different colors, i.e., green, yellow, orange, and red). The presence of (poly)phenols was quantified and characterized, and scavenging activity was determined by the Folin–Ciocâlteu reagent and the DPPH method, respectively. The content of bioactive compoun…
Polysubstituted ferrocenes as tunable redox mediators
2018
A series of four ferrocenyl ester compounds, 1-methoxycarbonyl- (1), 1,1’-bis(methoxycarbonyl)- (2), 1,1’,3-tris(methoxycarbonyl)- (3) and 1,1’,3,3’-tetrakis(methoxycarbonyl)ferrocene (4), has been studied with respect to their potential use as redox mediators. The impact of the number and position of ester groups present in 1–4 on the electrochemical potential E1/2 is correlated with the sum of Hammett constants. The 1/1+–4/4+ redox couples are chemically stable under the conditions of electrolysis as demonstrated by IR and UV–vis spectroelectrochemical methods. The energies of the C=O stretching vibrations of the ester moieties and the energies of the UV–vis absorptions of 1–4 and 1+–4+ c…