Search results for "MRSA"

Klīniski nozīmīgas bakteriēmijas Rīgas multidisciplinārā slimnīcā

2020

Asinsrites infekcijas – bakteriēmijas globāli atzītas par vienu no galvenajiem iemesliem, kas ietekmē gan saslimstību, gan mirstību, un to incidence pieaug. Joprojām paliek neskaidrs, kas ietekmē dinamisku bakteriēmiju pieaugumu – izmaiņas patogēnsspecifiskā transmisijā, virulencē vai rezistencē, novecojusi populācija vai pārmērīgi kompleksa medicīnas aprūpe vai visu faktoru kombinācija. Viena no iespējām ir baktērijas adaptīvie atbildes mehānismi – antimikrobiālās rezistences veidošanās.

Characterization of MRSA from Palermo, Italy, and description of prevalent clones

2011

Circolazione di MRSA in età pediatrica in ambiente ospedaliero e in comunità

2013

Introduzione. Negli ultimi anni si è assistito ad un generale incremento e ad una sempre più estesa diffusione, sia in ambito ospedaliero che comunitario, di microrganismi multiresistenti. In assenza ed in attesa di trattamenti farmacologici efficaci maggiore attenzione deve essere impiegata alla realizzazione di strategie di sorveglianza mirate. Il primo isolamento di un ceppo di Staphylococcus aureus meticillinoresistente (MRSA) risale al 1961 e fu seguito da una repentina diffusione negli ospedali di tutto il mondo. Ad oggi MRSA è riconosciuto come uno dei principali agenti responsabili delle infezioni nosocomiali e le percentuali di isolamento variano da Paese in Paese in maniera notevo…

tst1-positive ST22-MRSA-IVa in healthy Italian preschool children

2013

A survey was performed in May 2013 to assess methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization in healthy children attending 26 municipal daycare centres in Palermo, Italy. Of the 500 children, ten (2 %) tested positive. Eight MRSA isolates were tst1-positive ST22-MRSA-IVa, spa t223; the other two isolates were identified as ST1-IVa and ST398-V, respectively. tst1-positive ST22-MRSA, spa t223 has been previously identified only in the Middle Eastern area.

Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study

2016

BACKGROUND: Antibiotic resistance is a major global health problem and pathogens such as meticillin-resistant Staphylococcus aureus (MRSA) have become of particular concern in the management of lower respiratory tract infections. However, few data are available on the worldwide prevalence and risk factors for MRSA pneumonia. We aimed to determine the point prevalence of MRSA pneumonia and identify specific MRSA risk factors in community-dwelling patients hospitalised with pneumonia.METHODS: We did an international, multicentre study of community-dwelling, adult patients admitted to hospital with pneumonia who had microbiological tests taken within 24 h of presentation. We recruited investig…

Panton-Valentine leukocidin positive sequence type 80 methicillin-resistant Staphylococcus aureus carrying a staphylococcal cassette chromosome mec t…

2012

Methicillin-resistant Staphylococcus aureus (MRSA) is a major antimicrobial drug-resistant pathogen causing serious infections. It was first detected in healthcare settings, but in recent years it has also become disseminated in the community. Children and young adults are most susceptible to infection by community-acquired (CA) MRSA strains. In this study 25 MRSA isolates implicated in infections of neonates and children admitted to an Algiers hospital during an 18 month period were characterized by molecular methods including staphylococcal cassette chromosome (SCC) mec typing, PCR amplification of pvl genes, pulsed field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). F…

Methicillin-resistant staphylococcus aureus from pressure ulcers in patients receiving home care in Palermo, Italy

2009

Dear Sir,Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent and serious threat to hospitalized patients globally and now represents a challenge for public health, as community-acquire...

Novel strategies in the war against antibiotic resistance

2021

The global threat of antibiotic resistance is steadily growing. Antibiotic resistancemay involve any class of antibiotic, including second- and third-line agents that have been considered to date the last-resort drugs to counteract common infections. We may lose our capability to keep under control many common bacterial infections [1]. Despite this, in the past decade significant research efforts have been made to develop new antibacterial strategies able to treat multidrug-resistant infections; however, no new therapeutic approach has yet reached the clinic [2,3]. In order to identify new valuable antimicrobial drugs, it is important to consider the main bacterial resistance mechanisms in …

Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections

2021

Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as one of the leading causes of persistent human infections. This pathogen is widespread and is able to colonize asymptomatically about a third of the population, causing moderate to severe infections. It is currently considered the most common cause of nosocomial infections and one of the main causes of death in hospitalized patients. Due to its high morbidity and mortality rate and its ability to resist most antibiotics on the market, it has been termed a “superbug”. Its ability to form biofilms on biotic and abiotic surfaces seems to be the primarily means of MRSA antibiotic resistance and pervasiveness. Importantly, more tha…

Descriptive epidemiology of nasal carriage of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus among patients admitted to two he…

2014

Aim: To evaluate nasal carriage rate and variables associated with Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) in patients admitted in two healthcare facilities. Results: S. aureus was isolated from 159 (26%) of the enrolled patients. Methicillin-susceptible S. aureus was isolated from 150 (24.5%) patients, and MRSA was isolated from 9 (1.5%). Cancer and previous hospitalization were associated with a significantly higher frequency of nasal S. aureus carriage among the patients admitted to the general hospital and the nephrology department, respectively. MRSA isolates were heterogeneous with respect to their staphylococcal cassette chromosome mec element (SC…