Search results for "MT"
showing 10 items of 2759 documents
The Histone Deacetylase Inhibitor JAHA Down-Regulates pERK and Global DNA Methylation in MDA-MB231 Breast Cancer Cells
2015
The histone deacetylase inhibitor N-1-(ferrocenyl)-N-8-hydroxyoctanediamide (JAHA) down-regulates extracellular-signal-regulated kinase (ERK) and its activated form in triple-negative MDA-MB231 breast cancer cells after 18 h and up to 30 h of treatment, and to a lesser extent AKT and phospho-AKT after 30 h and up to 48 h of treatment. Also, DNA methyltransferase 1 (DNMT1), 3b and, to a lesser extent, 3a, downstream ERK targets, were down-regulated already at 18 h with an increase up to 48 h of exposure. Methylation-sensitive restriction arbitrarily-primed (MeSAP) polymerase chain reaction (PCR) analysis confirmed the ability of JAHA to induce genome-wide DNA hypomethylation at 48 h of expos…
“DNA Methyl transferase 1 post-trascriptional silencing indues aneuploidy and cell cycle arrest in human cells”,
2009
"Table 6" of "Observation of electroweak $W^{\pm}Z$ boson pair production in association with two jets in $pp$ collisions at $\sqrt{s} =$ 13 TeV with…
2019
Measured $W^{pm}Zjj$ differential cross-section in the VBS fiducial phase space. The relative uncertainties are reported as percentages. The systematic uncertainties are in order of appearance: total uncorrelated systematic and correlated systematics related respectively to unfolding, electrons, muons, jets, reducible and irreducible backgrounds, pileup and luminosity. The last bin is a cross section for all events above the lower end of the bin.
"Table 7" of "Observation of electroweak $W^{\pm}Z$ boson pair production in association with two jets in $pp$ collisions at $\sqrt{s} =$ 13 TeV with…
2019
Correlation matrix for the unfolded fiducial cross-section.
Rotational Raman spectroscopy of ethylene using a femtosecond time-resolved pump-probe technique.
2005
154309; Femtosecond Raman-induced polarization spectroscopy (RIPS) was conducted at low pressure (250 mb at 295 K and 400 mb at 373 K) in ethylene. The temporal signal, resulting from the beating between pure rotational coherences, was measured with a heterodyne detection. The temporal traces were converted to the frequency domain using a Fourier transformation and then analyzed thanks to the D2hTDS software (http://www.u-bourgogne.fr/LPUB/shTDS.html) dedicated to X2Y4 molecules with D2h symmetry. The effective Hamiltonian was expanded up to order 2, allowing the determination of five parameters with an rms of 0.017 cm(-1). Special care was taken in the precise modeling of intensities, taki…
Ultrafast Optical Demagnetization manipulates Nanoscale Spin Structure in Domain Walls
2012
During ultrafast demagnetization of a magnetically ordered solid, angular momentum has to be transferred between the spins, electrons, and phonons in the system on femto- and picosecond timescales. Although the intrinsic spin-transfer mechanisms are intensely debated, additional extrinsic mechanisms arising due to nanoscale heterogeneity have only recently entered the discussion. Here we use femtosecond X-ray pulses from a free-electron laser to study thin film samples with magnetic domain patterns. We observe an infrared-pump-induced change of the spin structure within the domain walls on the sub-picosecond timescale. This domain-topography-dependent contribution connects the intrinsic dem…
The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser
2019
Phytochrome proteins control the growth, reproduction, and photosynthesis of plants, fungi, and bacteria. Light is detected by a bilin cofactor, but it remains elusive how this leads to activation of the protein through structural changes. We present serial femtosecond X-ray crystallographic data of the chromophore-binding domains of a bacterial phytochrome at delay times of 1 ps and 10 ps after photoexcitation. The data reveal a twist of the D-ring, which leads to partial detachment of the chromophore from the protein. Unexpectedly, the conserved so-called pyrrole water is photodissociated from the chromophore, concomitant with movement of the A-ring and a key signaling aspartate. The chan…
Application of time-resolved spectroscopy to concentration measurements in gas mixtures
2001
1296-2147; Concentration measurements using femtosecond Raman Induced Polarization Spectroscopy (RIPS) are performed in binary gas mixtures CO2-N2 and CO2-N2O at room temperature. The principle of these measurements is based on the nonlinear rotational time response of each molecular component of the mixture, The general form of this molecular response is a series of periodic transients with a period related to the rotational constant Be The relative strength of the individual responses allows an accurate determination of the concentration. Two techniques are presented using either two pulses (one pump and one probe) or three pulses (two pumps and one probe). (C) 2001 Academie des sciences/…
Latviešu valodas prasmju attīstīšanas veicināšana mazākumtautības pirmsskolas izglītības iestādē
2017
Darba autore : Alla Radionova Darba veids: Diplomdarbs Studiju programma: Pirmsskolas izglītības skolotājs Darba zinātniskā vadītāja: Ieva Margeviča-Grinberga, Latvijas Universitātes docente Mērķis: Izpētīt latviešu valodas prasmju attīstības veicināšanas iespējas mazākumtautības pirmsskolas izglītības iestādē. Pētījuma hipotēze: pirmsskolas vecuma bērnam otrās valodas apguve būs sekmīga, ja: •bērni nodarbību laikā izjutīs pozitīvu noskaņojumu un interesi par otrās valodas mācīšanos; •pedagogs strādā bilingvāli visā dienas gaitā. Pētījuma uzdevumi ir a) izpētīt un izklāstīt bilingvālās izglītības metodikas būtību; b) raksturot bērnu runātprasmju attīstības īpatnības vecumā no 4 līdz 5 gadie…