Search results for "MVD"

showing 5 items of 5 documents

Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A

2018

International audience; Filamin A (FLNa), expressed in endocardial endothelia during fetal valve morphogenesis, is key in cardiac development. Missense mutations in FLNa cause non-syndromic mitral valve dysplasia (FLNA-MVD). Here, we aimed to reveal the currently unknown underlying molecular mechanism behind FLNA-MVD caused by the FLNa P637Q mutation. The solved crystal structure of the FLNa3-5 P637Q revealed that this mutation causes only minor structural changes close to mutation site. These changes were observed to significantly affect FLNa's ability to transmit cellular force and to interact with its binding partner. The performed steered molecular dynamics simulations showed that signi…

Filamins[SDV]Life Sciences [q-bio]Protein Tyrosine Phosphatase Non-Receptor Type 12Heart Valve DiseasesMutation MissenseMorphogenesisProtein tyrosine phosphataseMolecular Dynamics SimulationBiologyFilaminta3111ArticleFLNA-MVD03 medical and health sciencessteered molecular dynamics simulationsStructural Biologymechanical forcesmedicineHumansMitral valve prolapseMissense mutationFLNAmolekyylidynamiikkasydäntauditCell adhesionMolecular Biology030304 developmental biologyX-ray crystallography0303 health sciencesBinding Sites030302 biochemistry & molecular biologyta1182filamiinitprotein tyrosine phosphatase 12medicine.disease3. Good healthCell biologyFilamin AMutation (genetic algorithm)cardiovascular systemMitral Valveproteiinitmitral valve prolapseröntgenkristallografiaProtein Binding
researchProduct

Trigemināla neiralģija: ārstēšanas analīze pēc mikrovaskulāras dekompresijas ķirurģijas

2017

Ievads: Trigemināla neiralģija (TN) ir sindroms, kas izsauc ļoti stipras lēkmjveida sāpes, kas izstaro sejā un ko var raksturot kā durošus, līdzīgus elektriskai strāvai paraksizmus. Ir uzskatīts, ka TN etioloģijas pamatā ir hroniskais neirovaskulārais kontakts (t.s. neirovaskulārais konflikts) starp asinsvadu un nervu. Rezultātā asinsvads spiež uz nervu, veidojas nervu mielīna apvalka bojājums, pastāvīgs nervu šķiedru nociceptīvo receptoru kairinājums, kas izpaužas ar sāpēm. Visbiežāk patoloģiju diagnosticē diezgan vēli. Terapija sākumposmā ir Carbamazepine (CBZ), Un ja tas nav efektīvs, tad jādomā par operatīvo ārstēšanu. Ņemot vērā, ka vaskulārā kompresija ir visbiežākais iemesls primārai…

MVDSurgeryTrigeminal NeuralgiaNervus TrigeminusMedicīnaMicrovascular Decompression Surgery
researchProduct

Associations of rs3918242 and rs2285053 MMP-9 and MMP-2 polymorphisms with the risk, severity, and short- and long-term complications of degenerative…

2016

Abstract Background Degenerative forms of mitral valve diseases (MVDs) are very complex pathologies. Thus, it is difficult to make generalizations about the disease pathways or genetic risk factors contributing to these diseases. However, a key role of metalloproteinases (MMPs) in their pathophysiology is emerging. Thus, we performed for the first time a perspective study to assess eventual associations of some functional single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes with the MVD risk, symptom severity, and short- and long-term (4.8 years) complications. Materials and methods For this purpose, 90 patients and two control groups were genotyped for rs3918242, rs243865, and r…

MalePathologyHeart Valve DiseasesDisease030204 cardiovascular system & hematologyMatrix metalloproteinasers3918242 rs243865 rs2285053 MMP-2 and MMP-9 gene SNPDegenerative forms of mitral valve diseases; Management and outcome; Metalloproteinases; rs3918242 rs243865 rs2285053 MMP-2 and MMP-9 gene SNPs; Aged; Cohort Studies; Female; Genetic Predisposition to Disease; Genotype; Heart Valve Diseases; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Mitral Valve; Prospective Studies; Risk Factors; Polymorphism Single Nucleotide0403 veterinary scienceCohort Studies0302 clinical mediciners2285053 MMP-2 and MMP-9 gene SNPsRisk FactorsGenotypeManagement and outcomeNatriuretic peptideProspective StudiesProspective cohort studyMVDSMetalloproteinaseDegenerative forms of mitral valve diseases04 agricultural and veterinary sciencesGeneral MedicineSingle NucleotideMiddle AgedMetalloproteinasesPathophysiologyMatrix Metalloproteinase 9Matrix Metalloproteinase 2Mitral ValveFemalers3918242Cardiology and Cardiovascular MedicineDegenerative forms of mitral valve diseasemedicine.medical_specialtyGenotype040301 veterinary sciencesmedicine.drug_class2734Single-nucleotide polymorphismDegenerative forms of mitral valve diseases; Management and outcome; Metalloproteinases; rs3918242 rs243865 rs2285053 MMP-2 and MMP-9 gene SNPs; Cardiology and Cardiovascular Medicine; 2734Polymorphism Single NucleotidePathology and Forensic Medicine03 medical and health sciencesInternal medicinemedicineHumansGenetic Predisposition to Diseasers243865PolymorphismAgedbusiness.industrySettore MED/23 - Chirurgia Cardiacabusiness
researchProduct

Efecto de la radiación ionizante persistente a bajas dosis en la angiogénesis del carcinoma renal de células claras : estudio morfométrico comparativ…

2013

La angiogénesis en el carcinoma de células renales claras (ccRCC) es un proceso influenciado por sustancias producidas en su mayoría por el tumor en respuesta a una reestructuración vascular necesaria en su etapa de crecimiento y metástasis. La exposición persistente a bajas dosis de radiación ionizante (CPLDIR) ha sido asociada a modificaciones nucleares que estimulan la proliferación celular neoplásica. Sus efectos en el proceso de neovascularización de los ccRCC han sido poco estudiados. Métodos: Estudiamos a través de un estudio morfométrico semiautomático e inmunohistoquímico, la densidad microvascular (MVD) y la expresión de factores angiogénicos en 124 pacientes con ccRCC de regiones…

angiogenesisclear cell renal cell carcinoma (ccRCC)microvascular density (MVD)UNESCO::CIENCIAS MÉDICASimmunohistochemistryangiogenic factorsradiation exposure to persistent low-dose (CPLDIR):CIENCIAS MÉDICAS [UNESCO]morphometry
researchProduct

An agile process modelling approach for BIM projects

2016

International audience; In the domain of Building Information Modelling (BIM), the open standardisation of methods for product and process modelling is undertaken by the buildingSMART association. Currently, buildingSMART recommends the use of Business Process Model and Notation (BPMN) for creating process models in Information Delivery Manuals (IDMs). This paper argues that BPMN is closely linked to the waterfall nature of today’s BIM projects, leading to a number of issues including long project durations, lack of stakeholder involvement, and disconnect of processes and data. Subject-oriented Business Process Management (S-BPM) is introduced as an alternative modelling approach for IDMs, …

buildingSmart[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process EngineeringMVD[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process EngineeringS-BPMBIM[ SPI.GPROC ] Engineering Sciences [physics]/Chemical and Process Engineeringprocess modellingIDMGeneralLiterature_MISCELLANEOUS
researchProduct