Search results for "Map"
showing 10 items of 3484 documents
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
2014
Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs47336…
Precipitation responses to ENSO and IOD in the Maldives: Implications of large-scale modes of climate variability in weather-related preparedness
2020
Abstract This research seeks to address the extent to which indices of large-scale modes of climate variability (El Nino Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD)) can be linked to physical differences in the local mean and extreme rainfall conditions experienced in the Maldives in order to suggest implications for disaster risk reduction (DRR). While some significant differences in precipitation metrics do occur at the local level between different phases of the large-scale modes of climate variability studied, they do not occur for all sites studied. While the constrained availability of historical meteorological data in the region is a limiting factor in this analysis, th…
Mapping genomic rearrangements in titi monkeys by chromosome flow sorting and multidirectional in-situ hybridization.
2004
We developed chromosome painting probes for Callicebus pallescens from flow-sorted chromosomes and used multidirectional chromosome painting to investigate the genomic rearrangements in C. cupreus and C. pallescens. Multidirectional painting provides information about chromosomal homologies at the subchromosomal level and rearrangement break points, allowing chromosomes to be used as cladistic markers. Chromosome paints of C. pallescens were hybridized to human metaphases and 43 signals were detected. Then, both human and C. pallescens probes were hybridized to the chromosomes of another titi monkey, C. cupreus. The human chromosome paints detected 45 segments in the haploid karyotype of C.…
On semi-fredholm properties of a boundary value problem inR + n
1988
The paper considers a boundary value problem with the help of the smallest closed extensionL ∼ :H k →H k 0×B h 1×...×B h N of a linear operatorL :C (0) ∞ (R + n ) →L(R + n )×L(R n−1)×...×L(R n−1). Here the spacesH k (the spaces ℬ h ) are appropriate subspaces ofD′(R + n ) (ofD′(R n−1), resp.),L(R + n ) andC (0) ∞ (R + n )) denotes the linear space of smooth functionsR n →C, which are restrictions onR + n of a function from the Schwartz classL (fromC 0 ∞ , resp.),L(R n−1) is the Schwartz class of functionsR n−1 →C andL is constructed by pseudo-differential operators. Criteria for the closedness of the rangeR(L ∼) and for the uniqueness of solutionsL ∼ U=F are expressed. In addition, ana prio…
Unbounded Linear Operators in Hilbert Spaces
2002
In order to make this monograph self-contained, we summarize in this chapter some basic definitions and results for unbounded linear operators in a Hilbert space. In Section 1.1, we recall the definitions of C*-algebras and von Neumann algebras. In Section 1.2, we define and investigate the notion of closedness, the closure and the adjoint of an unbounded linear operator in a Hilbert space. Section 1.3 is devoted to the Cayley transform approach to the self-adjointness of a symmetric operator. Section 1.4 deals with the self-adjoint extendability of a symmetric operator with help of the deficiency spaces. In Section 1.5, we extend to unbounded self-adjoint operators the spectral theorem and…
Fast Decentralized Linear Functions via Successive Graph Shift Operators
2019
Decentralized signal processing performs learning tasks on data distributed over a multi-node network which can be represented by a graph. Implementing linear transformations emerges as a key task in a number of applications of decentralized signal processing. Recently, some decentralized methods have been proposed to accomplish that task by leveraging the notion of graph shift operator, which captures the local structure of the graph. However, existing approaches have some drawbacks such as considering special instances of linear transformations, or reducing the family of transformations by assuming that a shift matrix is given such that a subset of its eigenvectors spans the subspace of i…
Mapping wordnets from the perspective of inter-lingual equivalence
2017
Mapping wordnets from the perspective of inter-lingual equivalence This paper explores inter-lingual equivalence from the perspective of linking two large lexico-semantic databases, namely the Princeton WordNet of English and the plWordnet ( pl. Slowosiec ) of Polish. Wordnets are built as networks of lexico-semantic relations between words and their meanings, and constitute a type of monolingual dictionary cum thesaurus. The development of wordnets for different languages has given rise to many wordnet linking projects (e.g. EuroWordNet, Vossen, 2002). Regardless of a linking method used, these projects require defining rules for establishing equivalence links between wordnet building bloc…
Phenolic-glycolipid-1 and lipoarabinomannan preferentially modulate TCR- and CD28-triggered proximal biochemical events, leading to T-cell unresponsi…
2012
Abstract Background Advanced stages of leprosy show T cell unresponsiveness and lipids of mycobacterial origin are speculated to modulate immune responses in these patients. Present study elucidates the role of phenolicglycolipid (PGL-1) and Mannose-capped lipoarabinomannan (Man-LAM) on TCR- and TCR/CD28- mediated signalling. Results We observed that lipid antigens significantly inhibit proximal early signalling events like Zap-70 phosphorylation and calcium mobilization. Interestingly, these antigens preferentially curtailed TCR-triggered early downstream signalling events like p38 phosphorylation whereas potentiated that of Erk1/2. Further, at later stages inhibition of NFAT binding, IL-2…
Expressional control of the ‘constitutive’ isoforms of nitric oxide synthase (NOS I and NOS III)
1998
Nitric oxide synthase (NOS) exists in three established isoforms. NOS I (NOS1, ncNOS) was originally discovered in neurons. This enzyme and splice variants thereof have since been found in many other cells and tissues. NOS II (NOS2, iNOS) was first identified in murine macrophages, but can also be induced in many other cell types. NOS III (NOS3, ecNOS) is expressed mainly in endothelial cells. Whereas NOS II is a transcriptionally regulated enzyme, NOS I and NOS III are considered constitutively expressed proteins. However, evidence generated in recent years indicates that these two isoforms are also subject to expressional regulation. In view of the important biological functions of these …
2′O-galloylhyperin attenuates LPS-induced acute lung injury via up-regulation antioxidation and inhibition of inflammatory responses in vivo
2019
2'O-galloylhyperin, an active flavonol glycoside compound with remarkable anti-immune activity, was isolated from Pyrola [P. incarnata Fisch.]. However, the evidence of anti-inflammatory activity in pulmonary diseases was still not convincing. The aim of the present study was (1) to investigate the effect of 2'O-galloylhyperin on LPS-induced acute lung injury in mice, and (2) to identify the mechanisms of attenuation of inflammatory responses. The results demonstrated that 2'O-galloylhyperin significantly reduced LPS-induced inflammation damage in a dose-dependent manner. After LPS challenge, treatment with 2'O-galloylhyperin reduced the production of pro-inflammatory cytokines and chemokin…