Search results for "Maps"
showing 10 items of 236 documents
Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo
2015
Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors. Here, we show that Hox proteins are able to interact with a wide range of transcription factors in the live Drosophila embryo. In this context, specificity relies on a versatile usage of conserved short linear motifs (SLiMs), which, surprisingly, often restrains the interaction potential of Hox proteins. This novel buffering activity of SLiMs was observed in different tissues and found in Hox proteins from cnidarian to mouse species. Although th…
Islands of biogeodiversity in arid lands on a polygons map study: Detecting scale invariance patterns from natural resources maps.
2016
Many maps (geology, hydrology, soil, vegetation, etc.) are created to inventory natural resources. Each of these resources is mapped using a unique set of criteria, including scales and taxonomies. Past research indicates that comparing results of related maps (e.g., soil and geology maps) may aid in identifying mapping deficiencies. Therefore, this study was undertaken in Almeria Province, Spain to (i) compare the underlying map structures of soil and vegetation maps and (ii) investigate if a vegetation map can provide useful soil information that was not shown on a soil map. Soil and vegetation maps were imported into ArcGIS 10.1 for spatial analysis, and results then exported to Microsof…
Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature
2015
Despite massive investments in drug research and development, the significant decline in the number of new drugs approved or translated to clinical use raises the question, whether single targeted drug discovery is the right approach. To combat complex systemic diseases that harbour robust biological networks such as cancer, single target intervention is proved to be ineffective. In such cases, network pharmacology approaches are highly useful, because they differ from conventional drug discovery by addressing the ability of drugs to target numerous proteins or networks involved in a disease. Pleiotropic natural products are one of the promising strategies due to their multi-targeting and d…
Diffusion map for clustering fMRI spatial maps extracted by Indipendent Component Analysis
2013
Functional magnetic resonance imaging (fMRI) produces data about activity inside the brain, from which spatial maps can be extracted by independent component analysis (ICA). In datasets, there are n spatial maps that contain p voxels. The number of voxels is very high compared to the number of analyzed spatial maps. Clustering of the spatial maps is usually based on correlation matrices. This usually works well, although such a similarity matrix inherently can explain only a certain amount of the total variance contained in the high-dimensional data where n is relatively small but p is large. For high-dimensional space, it is reasonable to perform dimensionality reduction before clustering.…
Hybrid chaotic firefly decision making model for Parkinson’s disease diagnosis
2020
Parkinson’s disease is found as a progressive neurodegenerative condition which affects motor circuit by the loss of up to 70% of dopaminergic neurons. Thus, diagnosing the early stages of incidence is of great importance. In this article, a novel chaos-based stochastic model is proposed by combining the characteristics of chaotic firefly algorithm with Kernel-based Naïve Bayes (KNB) algorithm for diagnosis of Parkinson’s disease at an early stage. The efficiency of the model is tested on a voice measurement dataset that is collected from “UC Irvine Machine Learning Repository.” The dynamics of chaos optimization algorithm will enhance the firefly algorithm by introducing six types of chao…
Common fixed point theorems for (ϕ, ψ)-weak contractions in fuzzy metric spaces
2010
Motivated by Rhoades (Nonlinear Anal., 47 (2001), 2683--2693), on the lines of Khan et al. (Bull. Aust. Math. Soc., 30 (1984), 1-9) employing the idea of altering distances, we extend the notion of (ϕ, ψ)-weak contraction to fuzzy metric spaces and utilize the same to prove common fixed point theorems for four mappings in fuzzy metric spaces.
Optimal slope units partitioning in landslide susceptibility mapping
2020
In landslide susceptibility modeling, the selection of the mapping units is a very relevant topic both in terms of geomorphological adequacy and suitability of the models and final maps. In this paper, a test to integrate pixels and slope units is presented. MARS (Multivariate Adaptive Regression Splines) modeling was applied to assess landslide susceptibility based on a 12 predictors and a 1608 cases database. A pixel-based model was prepared and the scores zoned into 10 different types of slope units, obtained by differently combining two half-basin (HB) and four landform classification (LCL) coverages. The predictive performance of the 10 models were then compared to select the best perf…
Geomorphological tools for mapping natural hazards
2021
This special issue presents contributions about the methodologies and tools for representing and mapping geomorphological hazards, with a focus upon hazard and risk classification and tools for lan...
p63 Isoforms Regulate Metabolism of Cancer Stem Cells
2014
p63 is an important regulator of epithelial development expressed in different variants containing (TA) or lacking (ΔN) the N-terminal transactivation domain. The different isoforms regulate stem-cell renewal and differentiation as well as cell senescence. Several studies indicate that p63 isoforms also play a role in cancer development; however, very little is known about the role played by p63 in regulating the cancer stem phenotype. Here we investigate the cellular signals regulated by TAp63 and ΔNp63 in a model of epithelial cancer stem cells. To this end, we used colon cancer stem cells, overexpressing either TAp63 or ΔNp63 isoforms, to carry out a proteomic study by chemical-labeling …
Mappings of Finite Distortion : Compactness of the Branch Set
2017
We show that an entire branched cover of finite distortion cannot have a compact branch set if its distortion satisfies a certain asymptotic growth condition. We furthermore show that this bound is strict by constructing an entire, continuous, open and discrete mapping of finite distortion which is piecewise smooth, has a branch set homeomorphic to an (n - 2)-dimensional torus and distortion arbitrarily close to the asymptotic bound. Peer reviewed