Search results for "Marginal"
showing 10 items of 350 documents
Over 30% of Patients with Splenic Marginal Zone Lymphoma Express Distinctive Antigen Receptors Utilizing a Single Immunoglogulin Variable Gene: Impli…
2010
Abstract Abstract 634 We systematically explored the immunoglobulin (IG) gene repertoire in 337 cases with splenic marginal-zone lymphoma (SMZL), by far the largest series yet. To resolve classification uncertainties, we included in the analysis only cases with a diagnosis of SMZL based on spleen histopathological findings or cases fulfilling the 2008 SBLG criteria (Matutes et al. Leukemia 2008). We here report that the IG heavy variable (IGHV) gene repertoire in SMZL is remarkably biased, with only three genes accounting for 45.8% of cases (IGHV1-2, 24.9%; IGHV4-34, 12.8%; IGHV3-23: 8.1%, respectively), significantly extending previous similar observations. Particularly for the IGHV1-2 gen…
Distinctive Patterns of Intraclonal Diversification In IGHV1-2*04 Immunoglobulin Receptors of Patients with Splenic Marginal Zone Lymphoma: A of Ongo…
2011
Abstract Abstract 2638 We recently demonstrated that over 30% of cases with splenic marginal-zone lymphoma (SMZL) express distinctive immunoglobulin (IG) receptors that utilize a single polymorphic variant of the IGHV1-2 gene (IGHV1-2*04) and also exhibit restricted antigen-binding site motifs and precise targeting of somatic hypermutation (SHM). On these grounds, we proposed the existence of molecular subtypes of SMZL defined by immunogenetic analysis of the IG receptors with implications for selection by specific (super) antigenic element(s) in the development of at least a major subset of SMZL. In order to gain insight as to whether antigen involvement is relevant only prior to the malig…
7. Mobility comparisons: Does using different measures matter?
2004
In this paper we review alternative measure of intergenerational mobility, emphasizing the distinction between absolute, relative and ordinal mobility. We then compare the performance of various mobility indices using real data. FromTreiman and Ganzeboom (1990) dataset we compare the degree of occupational and educational intergenerational (father-son) mobility in 16 countries in a single year (comprised between 1968 and 1982). From three Bank of Italy surveys (1993, 1995, 1998) we obtain a comparable measure of social prestige and we show that intergenerational mobility in Italy across regions or age cohort exhibits different trends according to different indicators. We suggest that ordina…
Lymphoid lesions of salivary glands : malignant and Benign
2007
Lesions of salivary glands with a prominent lymphoid component are a heterogeneous group of diseases that include benign reactive lesions and malignant neoplasms. Occasionally, these pathologic entities present difficulties in the clinical and pathological diagnosis and prognosis. Lymphoepithelial sialadenitis, HIV-associated salivary gland disease, chronic sclerosing sialadenitis, Warthin tumor, and extranodal marginal zone B-cell lymphoma are examples of this pathology that are sometimes problematic to differentiate from one another. In this paper the author reviewed the main clinical, pathological and prognostic features of these lesions.
AN ECONOMIC APPROACH TO THE STUDY OF LAW IN THE EIGHTEENTH CENTURY: GAETANO FILANGIERI AND LA SCIENZA DELLA LEGISLAZIONE
2011
This work presents the elements of economic analysis of law that occur in the thought of Gaetano Filangieri. In the pages of La Scienza della Legislazione the Neapolitan writer develops a utilitarian and economic investigation that pays attention to the judgments individuals make over social phenomena at the margin point. A proof of this development can be found in the explanation of the principle of decreasing marginal utility, argued in Head XXXI of Book III, which represents one of the most effective demonstrations that can be found before the end of nineteenth-century literature. The most remarkable fact is that, of all the five parts that compose the Filangierian work, the most rich in…
GREEN ECONOMY: THE DEVELOPMENT OF MARGINAL AREAS IN THE HORIZON 2020 STRATEGY
2014
Bioeconomy refers to a system based on the smart utilization of biological resources based on sources from land and sea as industrial input and production of food. The Bioeconomy will also contribute to limiting the negative impacts on the environment, reduce the heavy dependency on fossil resources, mitigate climate change and move Europe towards a post-petroleum society. The work aims to investigate how the territorial marginality linked to socio-economic disparities can be a competitive advantage for the challenges proposed by the bioeconomy innovation strategy. An example of a Sicilian bio-cluster is indicated for a significant product differentiation and functional integration of agric…
Sequential Monte Carlo Methods in Random Intercept Models for Longitudinal Data
2017
Longitudinal modelling is common in the field of Biostatistical research. In some studies, it becomes mandatory to update posterior distributions based on new data in order to perform inferential process on-line. In such situations, the use of posterior distribution as the prior distribution in the new application of the Bayes’ theorem is sensible. However, the analytic form of the posterior distribution is not always available and we only have an approximated sample of it, thus making the process “not-so-easy”. Equivalent inferences could be obtained through a Bayesian inferential process based on the set that integrates the old and new data. Nevertheless, this is not always a real alterna…
Multi-year drought frequency analysis at multiple sites by operational hydrology - A comparison of methods
2006
Abstract This paper compares two generators of yearly water availabilities from sources located at multiple sites with regard to their ability to reproduce the characteristics of historical critical periods and to provide reliable results in terms of the return period of critical sequences of different length. The two models are a novel multi-site Markov mixture model explicitly accounting for drought occurrences and a multivariate ARMA. In the case of the multisite Markov mixture model parameter estimation is limited to a search in the parameter space guided by the value of parameter λ to show the sensitivity of the model to this parameter. Application to two of the longest time series of …
Biophysical parameter estimation with adaptive Gaussian Processes
2009
We evaluate Gaussian Processes (GPs) for the estimation of biophysical parameters from acquired multispectral data. The standard GP formulation is used, and all hyperparameters (kernel parameters and noise variance) are optimized by maximizing the marginal likelihood. This gives rise to a fully-adaptive GP to data characteristics, both in terms of signal and noise properties. The good numerical results in the estimation of oceanic chlorophyll concentration and leaf membrane state confirm GPs as adequate, alternative non-parametric methods for biophysical parameter estimation. GPs are also analyzed by scrutinizing the predictive variance, the estimated noise variance, and the relevance of ea…
Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications.
2012
We performed an immunogenetic analysis of 345 IGHV-IGHD-IGHJ rearrangements from 337 cases with primary splenic small B-cell lymphomas of marginal-zone origin. Three immunoglobulin (IG) heavy variable (IGHV) genes accounted for 45.8% of the cases (IGHV1-2, 24.9%; IGHV4-34, 12.8%; IGHV3-23, 8.1%). Particularly for the IGHV1-2 gene, strong biases were evident regarding utilization of different alleles, with 79/86 rearrangements (92%) using allele *04. Among cases more stringently classified as splenic marginal-zone lymphoma (SMZL) thanks to the availability of splenic histopathological specimens, the frequency of IGHV1-2*04 peaked at 31%. The IGHV1-2*04 rearrangements carried significantly lo…