Search results for "Marr"
showing 10 items of 776 documents
Revista electrónica de investigación y evaluación educativa
2015
La investigación y la práctica relacionadas con el uso de estrategias empáticas en entornos educativos multiculturales se está revelando como una de las más eficaces vías para la lucha contra el sesgo intergrupal. El objeto del presente estudio es diseñar un instrumento de medición de la empatía intercultural en su componente afectivo, específico para la población española y hacia la población de origen marroquí, que permita diagnosticar este rasgo o capacidad antes de aplicar estrategias educativas en entornos multiculturales. Con este propósito se utilizaron dos muestras de estudiantes universitarios para realizar una validación cruzada y, mediante análisis factorial exploratorio (utiliza…
Zaangażowane badania jakościowe - perspektywa autobiograficzna
2017
Prezentowany artykuł jest próbą rekonstrukcji/retrospekcji mojej zawodowej biografii w jej fragmencie metodologicznym. Jest opisem drogi jaką przebyłam stając się badaczką narracyjną, biograficzną. Jest także opisem towarzyszących mi w tej drodze uzasadnień - teorii, koncepcji ,dyskusji i sporów. Przedstawiam w nim swoją krytyczną postawę wobec polskiej szkoły i polskiej edukacji stawiając pytanie o edukację, szkołę, nauczyciela. Drugim pytaniem, które organizuje moje postępowanie badawcze jest Pytanie o relacje między ludźmi, związki intymne, małżeństwo, rodzinę, o to, co dzieje się w nich „pomiędzy”: małżonkami, partnerami, rodzicami i dziećmi. Pytam o to, co w naszych relacjach z innymi …
Recombinant GM-CSF Induces in Vitro Differentiation of Dendritic Cells from Mouse Bone Marrow
1993
The unprecedented functional capacity of dendritic cells (DC) in sensitizing resting T cells and their role in triggering T dependent immune responses attract increasing interest in this unique accessory cell population. Like macrophages (Mph) DC have been described to originate in the bone marrow (BM) (1). While the cytokine-promoted in vitro differentiation of Mph from BM-cells is well established, a convincing in vitro culture system for propagating mouse DC from BM-cells has not yet been reported. This work demonstrates the differentiation of DC from mouse bone marrow cells by a short term in vitro culture system supplemented with rGM-CSF.
High-level secretion of tumor necrosis factor-alpha contributes to hematopoietic failure in hairy cell leukemia [see comments]
1989
Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in vitro colony assays. As potent producers of TNF-alpha, hairy cells could be identified, thus implicating the malignant population in the pathogenesis of hematopoietic failure due to inappropriate secretion of this cytokine.
High-level secretion of tumor necrosis factor-alpha contributes to hematopoietic failure in hairy cell leukemia [see comments]
1989
Abstract Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in vitro colony assays. As potent producers of TNF-alpha, hairy cells could be identified, thus implicating the malignant population in the pathogenesis of hematopoietic failure due to inappropriate secretion of this cytokine.
CD49d Expression Identifies a Chronic Lymphocytic Leukemia (CLL) Subset with High Levels of Circulating CD34 +Cells Co-Expressing Endothelial Cell Ma…
2009
Abstract Abstract 2329 Poster Board II-306 Introduction: In chronic lymphocytic leukemia (CLL), CD49d, often in association with CD38, has been shown to mark a disease subset with poor prognosis. Functionally, both molecules act as counter-receptors for surface structures (i.e. VCAM-1/CD106 and CD31) usually expressed by the endothelial/stromal component of tumor micro-environment. We have recently identified a micro-environmental circuitry which involves CD38 triggering, and eventually determines an enrichment of the VCAM-1/CD106-expressing endothelial component detected in the context of CLL infiltrates found in bone marrow biopsies. Data was also provided that CD49d/VCAM-1 interactions a…
Evaluation of Bone Marrow CD8+ tissue-Resident Memory T Cells in Multiple Myeloma
2019
Background: CD8+ T cell responses are an essential component of the adaptive immune system. After resolution of infection a small population of memory cells is formed. In relation to circulatory patterns, different subsets of memory CD8+ T cells can be identified: the central memory (CM) and the effector memory T cells (EM) (Martin MD, et al., Front Immunol. 2018). In addition, it has been described a subset of resident memory T cells (TRM) permanently living in peripheral tissues, including the bone marrow (BM) (Di Rosa F., et al., Nat Rev Immunol. 2016). It is conceivable that these cells can contribute to the defence toward haematological tumours infiltrating the BM. Therefore, we perfor…
Wybrane fenomeny mistyczne w doświadczeniu religijnym Alicji Lenczewskiej w świetle jej pism
2019
Artykuł traktuje o polskiej nauczycielce, katoliczce, Alicji Lenczewskiej (1934-2012), poślubionej mistycznie Bogu, autorce dwutomowego dzieła, w którym utrwaliła pouczenia Zbawiciela, przedstawiła dzieje swojej duszy i opisała otrzymane od Stwórcy nadzwyczajne charyzmaty, do których należy zaliczyć: mistyczne zaślubiny, ekstazy, stygmaty niewidzialne i obrazy duchowe.
Human interleukin-6 facilitates hepatitis B virus infection in vitro and in vivo.
2000
Abstract Background and aim. Research on hepatitis B virus (HBV) infection in vivo has been limited due to the absence of a suitable animal model. We have developed a human–mouse radiation chimera in which normal mice, preconditioned by lethal total body irradiation and radioprotected with SCID mouse bone marrow cells, are permissive for engraftment of human hematopoietic cells and solid tissues. This resulting human–mouse model, which comprises three genetically disparate sources of tissue, is therefore termed Trimera. This study was aimed at assessing the effect of human IL-6 on HBV infection in vivo in Trimera mice. Methods. Trimera mice were transplanted with human liver tissue fragment…
The Endovascular Management of an Iatrogenic Superior Gluteal Artery Rupture Following Bone Marrow Biopsy
2017
We herein report an uncommon case of a life-threatening retroperitoneal hematoma after a bone marrow biopsy. Two hours after iliac crest bone harvesting, the patient experienced syncope and severe hypotension. Urgent contrast-enhanced computed tomography demonstrated extravasation from the superior gluteal artery. Transcatheter coil embolization was performed successfully, without complications. Life-threatening complications caused by retroperitoneal bleeding after bone marrow biopsy are very rare. There are few reports on the use of endovascular treatment in the management of life-threatening hemorrhagic complications after bone marrow biopsy.