Search results for "Mediator"
showing 10 items of 339 documents
Neuron-Glial Interaction During Injury and Edema of the CNS
1994
During injury and ischemia of the CNS mediator compounds are released or activated which cause secondary swelling and damage of nerve cells. Such mediators are glutamate, acidosis, free fatty acids, or high extracellular potassium. Glial homeostatic mechanisms are activated to prevent the secondary injury from these mediators. The glial clearance mechanisms have been studied in detail using in vitro systems allowing for a close control of the glial environment. Current evidence suggests glial swelling to occur together with glutamate uptake or in response to extracellular acidosis. Glial swelling, therefore, is rather the result of homeostatic mechanisms than an indication of glial demise.
B cells assume the command
2015
A proinflammatory B cell cytokine activates autoimmunity, and B cell depletion treats multiple sclerosis (Li et al., this issue).
Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators
2021
Both the initiation and the resolution of inflammatory responses are governed by the sequential activation, migration, and control/suppression of immune cells at the site of injury. Bioactive lipids play a major role in the fine-tuning of this dynamic process in a timely manner. During inflammation and its resolution, polymorphonuclear cells (PMNs) and macrophages switch from producing pro-inflammatory prostaglandins and leukotrienes to specialized pro-resolving lipid mediators (SPMs), namely, lipoxins, resolvins, protectins, and maresins, which are operative at the local level to limit further inflammation and tissue injury and restore homeostasis. Accumulating evidences expand now the rol…
La mediazione linguistico-culturale nelle istituzioni giuridiche italiane: il contesto demografico, etnico e detentivo
2013
Il presente articolo analizza la situazione tutta italiana degli immigrati e soprattutto degli immigrati negli istituti di pena e le difficoltà di mediazione linguistica e culturale.
Kultūras reāliju tulkošana no latviešu uz angļu valodu tekstos par latviešu dzīvestilu
2017
Maģistra darba nosaukums ir "Kultūras reāliju tulkošana no latviešu uz angļu valodu tekstos par latviešu dzīvesstilu." Šajā darbā tiek iztirzāta kultūras reālijas definīcija un klasifikācija, kā arī galvenās problēmas un stratēģijas kā tulkot kultūras reāliju, un sasniegt līdzvērtību mērķa valodā. Tiek apskatīta arī tulka kā vidutāja starp kultūrām loma. Lai redzētu, kā kultūras reālijas tiek tulkotas, ir izmantoti dažādi piemēri no drukātajiem tūristu ceļvežiem, grāmatām un internetā pieejamajiem materiāliem. Maģistra darbā tiek analizēts, kuras stratēģijas ir izmantotas un vai tās var izmantot arī konferenču tulki. Pētījumi ir vērsti uz divu veidu kultūras reālijām: tradicionālie latviešu…
«Men for oss er det én Gud, Faderen» : et kritisk blikk på Richard Bauckhams kristologi
2012
Author's version of an article in the journal: Teologisk Tidsskrift. Also available from the publisher at: http://www.idunn.no/ts/tt/2012/01/art06 The article consists of two parts: Part one seeks to demonstrate (contra Bauckham) that Jewish monotheism in the Second Temple period was of a flexible character. It argues that Jewish writers in this period could attribute «divine functions» to figures beside God, while still feeling committed to «one God». The Jewish monotheism of this period was therefore not constituted by functions or characteristics, but rather by the exclusive worship of the one God. Part two argues that Paul describes Jesus with a high position beside God, while still fee…
Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity
2014
Resveratrol shows beneficial effects in inflammation-based diseases like cancer, cardiovascular and chronic inflammatory diseases. Therefore, the molecular mechanisms of the anti-inflammatory resveratrol effects deserve more attention. In human epithelial DLD-1 and monocytic Mono Mac 6 cells resveratrol decreased the expression of iNOS, IL-8 and TNF-α by reducing mRNA stability without inhibition of the promoter activity. Shown by pharmacological and siRNA-mediated inhibition, the observed effects are SIRT1-independent. Target-fishing and drug responsive target stability experiments showed selective binding of resveratrol to the RNA-binding protein KSRP, a central post-transcriptional regul…
The Inflammatory Feed-Forward Loop Triggered by the Complement Component C3 as a Potential Target in Endometriosis
2021
Copyright © 2021 Agostinis, Zorzet, Balduit, Zito, Mangogna, Macor, Romano, Toffoli, Belmonte, Morello, Martorana, Borelli, Ricci, Kishore and Bulla. The complement system is a major component of humoral innate immunity, acting as a first line of defense against microbes via opsonization and lysis of pathogens. However, novel roles of the complement system in inflammatory and immunological processes, including in cancer, are emerging. Endometriosis (EM), a benign disease characterized by ectopic endometrial implants, shows certain unique features of cancer, such as the capacity to invade surrounding tissues, and in severe cases, metastatic properties. A defective immune surveillance against…
Suppression and mediation effect in psychosocial intervention: differences, similarities and examples
2013
El presente trabajo compara el efecto mediador y el supresor de una tercera variable. Ambos efectos parcelan la varianza de la variable dependiente (Y). La mediación es la reducción, tras introducir una tercera variable (Z) en el modelo, de la proporción de varianza explicada directamente por la variable independiente (X) en la variable criterio (Y) y la supresión es el incremento de la proporción de varianza explicada directamente por la independiente en la variable criterio, al incluir la tercera variable en el modelo. Se analizan las características y diferencias de cada efecto y se examina en qué situaciones se produce uno u otro. Cada situación, compuesta de tres variables correlaciona…