Search results for "Medo"

A green and efficient method for the synthesis of homodimeric (β-dicarbonyl) arylmethanes and dihydropyridine from dimedone in water

2018

A direct method has been developed for the synthesis of the dihydropyridine ring system by means of Michael reaction. The reaction of dimedone with 1 .0 equiv. of amines in water provides intermediate product, which allowed dihydropyridine derivatives by intramolecular cyclization in various yields. Of particular interest is the use of the water as solvent of reaction and in absence of catalyst. Also these operating conditions protect the environment and economic points of view.Keywords: aqueous synthesis; bioactivity; dihydropyridine; dimedone; green method; selective conditions

Non-parametric approaches to the impact of Holstein heifer growth from birth to insemination on their dairy performance at lactation one

2012

SUMMARYParametric approaches have been used widely to model animal growth and study the impact of growth profile on performance. Individual variation is often not considered in such approaches. However, non-parametric modelling allows this. Such an approach, based on spline functions, was used to study the importance of growth profiles from age 0 to 15 months (i.e. insemination) on milk yield and composition in primiparous cows. A dataset of 447 heifers was used for analysis of growth performance; 296 of them were also used to study impact on lactation. All of them originated from a French experimental herd and were born between 1986 and 2006. Clustering methods were also tested. Comparison…

Structural clustering of millions of molecular graphs

2014

We propose an algorithm for clustering very large molecular graph databases according to scaffolds (i.e., large structural overlaps) that are common between cluster members. Our approach first partitions the original dataset into several smaller datasets using a greedy clustering approach named APreClus based on dynamic seed clustering. APreClus is an online and instance incremental clustering algorithm delaying the final cluster assignment of an instance until one of the so-called pending clusters the instance belongs to has reached significant size and is converted to a fixed cluster. Once a cluster is fixed, APreClus recalculates the cluster centers, which are used as representatives for…

Incrementally Assessing Cluster Tendencies with a~Maximum Variance Cluster Algorithm

2003

A straightforward and efficient way to discover clustering tendencies in data using a recently proposed Maximum Variance Clustering algorithm is proposed. The approach shares the benefits of the plain clustering algorithm with regard to other approaches for clustering. Experiments using both synthetic and real data have been performed in order to evaluate the differences between the proposed methodology and the plain use of the Maximum Variance algorithm. According to the results obtained, the proposal constitutes an efficient and accurate alternative.

Looking for representative fit models for apparel sizing

2014

This paper is concerned with the generation of optimal fit models for use in apparel design. Representative fit models or prototypes are important for defining a meaningful sizing system. However, there is no agreement among apparel manufacturers and each one has their own prototypes and size charts i.e. there is a lack of standard sizes in garments from different apparel manufacturers. We propose two algorithms based on a new hierarchical partitioning around medoids clustering method originally developed for gene expression data. We are concerned with a different application; therefore, the dissimilarity between the objects has to be different and must be designed to deal with anthropometr…

A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease.

2022

Purpose: The mediator (MED) multisubunit-complex modulates the activity of the transcriptional machinery, and genetic defects in different MED subunits (17, 20, 27) have been implicated in neurologic diseases. In this study, we identified a recurrent homozygous variant in MED11 (c.325C>T; p.Arg109Ter) in 7 affected individuals from 5 unrelated families. Methods: To investigate the genetic cause of the disease, exome or genome sequencing were performed in 5 unrelated families identified via different research networks and Matchmaker Exchange. Deep clinical and brain imaging evaluations were performed by clinical pediatric neurologists and neuroradiologists. The functional effect of the ca…

Folliculotropic Mycosis Fungoides With Flexural Eruptive Cysts and Comedones in a 14-Year-Old Boy

2021

2018

Marine sponges are a very attractive and rich source in the production of novel bioactive compounds. The sponges exhibit a wide range of pharmacological activities. The genus Amphimedon consists of various species, such as viridis, compressa, complanata, and terpenensis, along with a handful of undescribed species. The Amphimedon genus is a rich source of secondary metabolites containing diverse chemical classes, including alkaloids, ceramides, cerebrososides, and terpenes, with various valuable biological activities. This review covers the literature from January 1983 until January 2018 and provides a complete survey of all the compounds isolated from the genus Amphimedon and the associate…

Apparel sizing using trimmed PAM and OWA operators

2012

This paper is concerned with apparel sizing system design. One of the most important issues in the apparel development process is to define a sizing system that provides a good fit to the majority of the population. A sizing system classifies a specific population into homogeneous subgroups based on some key body dimensions. Standard sizing systems range linearly from very small to very large. However, anthropometric measures do not grow linearly with size, so they can not accommodate all body types. It is important to determine each class in the sizing system based on a real prototype that is as representative as possible of each class. In this paper we propose a methodology to develop an …

Extramammary Paget Disease of the Axilla Associated With Comedo-like Apocrine Carcinoma In Situ.

2002

Extramammary Paget disease of the axilla with underlying apocrine carcinoma has been reported only in six cases until now. This report deals with a seventh case characterized by the unique finding of comedo-like features evocative of large cell ductal breast carcinoma within an otherwise typical in situ apocrine carcinoma. This is characterized by spiral-shaped foci of epithelial proliferation with decapitation secretion and central masses of necrotic debris. A possible connection between the solid neoplasm and the overlying Paget disease is illustrated by a few apocrine-follicular units colonized by both the Paget cells and the structured adenocarcinoma. Here, although they display the sam…